Polysaccharide-based antibacterial coating technologies

Ruan, Haowen; Aulova, Alexandra; Ghai, Viney; Pandit, Santosh; Lovmar, Martin; Mijaković, Ivan; Kádár, Roland

doi:10.1016/j.actbio.2023.07.023

Cited by 21 publications

(15 citation statements)

References 248 publications

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“…As shown in Figure 2 a, the anti-biofouling surface characteristics of these implants are attributed to air pockets formed between the surface and the bacterial cell membrane, hindering complete contact [ 48 ]. Here, it is worth noting that such surfaces with hierarchical nanostructures can enhance fluid drag reduction and biofouling prevention by retaining trapped air under water [ 14 ]. This is attributed to the presence of air pockets significantly reducing the active solid surface area in contact with water, known as the “ Cassie fraction ” [ 49 ].…”

Section: Biofilm Formation On Orthopedic Implants and Prevention Stra...mentioning

confidence: 99%

“…Wetting these surfaces leads to water trapping due to surface roughness (known as the Wenzel wetting state ), and induces therefore the formation of surfaces coated with aqueous layers that effectively restrict bacterial attachment ( Figure 2 b,c) [ 56 ]. As most bacteria interact with surfaces through hydrophobic interactions, increasing the implant surface hydrophilicity is typically associated with an enhanced resistance to bacterial adhesion [ 14 , 57 ]. Polyethylene glycol (PEG) is the most popular anti-biofouling substance as it creates a relatively large exclusion volume on surfaces, leading to the determent of bacterial contamination [ 58 ].…”

Section: Biofilm Formation On Orthopedic Implants and Prevention Stra...mentioning

confidence: 99%

“…Surface topography is a successful tool for preventing the development of microbial biofilms on implants by killing and physically inactivating attached bacteria [ 7 , 14 ]. In addition to the topographic features at the nanoscale, bacterial cell-surface contact plays an important role in regulating physical damage, which is known in the literature as a contact killing.…”

Section: Biofilm Formation On Orthopedic Implants and Prevention Stra...mentioning

confidence: 99%

“…Orthopedic IAIs are severe complications resulting in implant failures, often require secondary implant replacement surgeries, and may lead to amputation or mortality, and represent, therefore, a major public health burden due to extended hospitalization, increased time of rehabilitation, and high healthcare costs [ 13 , 14 ]. It is also challenging to treat IAIs due to the typical metabolic heterogeneity of the biofilm-embedded microbial cells, which are not directly targeted by conventional antibiotic treatments [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections

Akay,

Yaghmur

2024

Molecules

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Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance to antimicrobial agents and the immune system. Thus, the viable options to eradicate biofilms embedded on medical implants are surgical operations and long-term and repeated antibiotic courses. Recent years have witnessed a growing interest in the development of robust and reliable strategies for prevention and treatment of IAIs. In particular, it seems promising to develop materials with anti-biofouling and antibacterial properties for combating IAIs on implants. In this contribution, we exclusively focus on recent advances in the development of modified and functionalized implant surfaces for inhibiting bacterial attachment and eventually biofilm formation on orthopedic implants. Further, we highlight recent progress in the development of antibacterial coatings (including self-assembled nanocoatings) for preventing biofilm formation on orthopedic implants. Among the recently introduced approaches for development of efficient and durable antibacterial coatings, we focus on the use of safe and biocompatible materials with excellent antibacterial activities for local delivery of combinatorial antimicrobial agents for preventing and treating IAIs and overcoming antimicrobial resistance.

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Section: Biofilm Formation On Orthopedic Implants and Prevention Stra...mentioning

confidence: 99%

Section: Biofilm Formation On Orthopedic Implants and Prevention Stra...mentioning

confidence: 99%

Section: Biofilm Formation On Orthopedic Implants and Prevention Stra...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections

Akay,

Yaghmur

2024

Molecules

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“…Chitosan, for example, is a polysaccharide that promotes bone cell growth and adhesion. Consequently, implants are more stable and stronger 97–101 …”

Section: Types Of Polymers Used In Coatings For Prosthetics and Implantsmentioning

confidence: 99%

Biopolymer‐based coatings for anti‐corrosion of Ti‐alloys used in biomedical applications: A review

Al‐Mosawi,

Abdulsada

2024

Polymer Engineering & Sci

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There are several enviable attributes of titanium and its alloys that contribute to their popularity in biomedical devices and equipment, including their rather low modulus, excellent corrosion resistance, and biocompatibility, good machinability, formability, and strength comprehensive impact and fatigue. Nevertheless, titanium and its alloys do not meet all medical requirements due to its unique properties and alloys, so surface modifications must be made to enhance mechanical, chemical, and biological characteristics. As a review of biomedical engineering, this article discusses specific polymers for coating applications as well as various polymer coatings for functionalization improvements. The versatility of biopolymer coatings makes them extremely appropriate for a broad range of biological uses. To enhance the engineering of tissue and drug delivery, this study summarized and analyzed the most recent advances in biopolymer coatings. Surface qualities of polymer coatings can be adjusted to meet specific criteria for various biomedical applications or integrated with new capabilities. Moreover, polymer coatings containing different inorganic ions can enhance the growth of tissue, proliferation of cells, healing, as well as the transfer of biomolecules, like active molecules, agents of antimicrobial, factors of growth, and medications.Highlights Surface modification avenues of Ti materials as orthopedic replacements are critically reviewed. Basic descriptions of titanium and titanium alloys are presented. Advances in the corrosion behavior of biomedical titanium alloys are thoroughly scrutinized. Fundamental methods based on mechanical, physical, and chemical principles for biopolymer coatings are particularly presented. Main biopolymer coatings types that are used on titanium surfaces are reviewed.

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