Polyphenolic–polysaccharide conjugates from plants of Rosaceae/Asteraceae family as potential radioprotectors

Żbikowska, Halina Małgorzata; Szejk, Magdalena; Saluk‐Bijak, Joanna; Pawlaczyk-Graja, Izabela; Gancarz, Roman; Olejnik, Alicja K.

doi:10.1016/j.ijbiomac.2016.01.090

Cited by 22 publications

(12 citation statements)

References 40 publications

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“…The numbers and characteristics of these phenol structures contribute to the unique features of polyphenol compound in term of chemical, physical, and biological (Scalbert and Williamson, 2000 ). In brief, polyphenols are secondary metabolites (Kabera et al, 2014 ) produced by plants, which is widely found in fruits and vegetables are thought to protect against ultraviolet radiation (Zbikowska et al, 2016 ) and pathogens invasion (Nagpala et al, 2016 ). Polyphenols also affect the flavor, color, and odor which contribute to the sensory perception of the food (Ju et al, 2017 ).…”

Section: Role Of Antioxidants In the Prevention Of Age-related Diseasmentioning

confidence: 99%

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

et al. 2018

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Aging is the progressive loss of organ and tissue function over time. Growing older is positively linked to cognitive and biological degeneration such as physical frailty, psychological impairment, and cognitive decline. Oxidative stress is considered as an imbalance between pro- and antioxidant species, which results in molecular and cellular damage. Oxidative stress plays a crucial role in the development of age-related diseases. Emerging research evidence has suggested that antioxidant can control the autoxidation by interrupting the propagation of free radicals or by inhibiting the formation of free radicals and subsequently reduce oxidative stress, improve immune function, and increase healthy longevity. Indeed, oxidation damage is highly dependent on the inherited or acquired defects in enzymes involved in the redox-mediated signaling pathways. Therefore, the role of molecules with antioxidant activity that promote healthy aging and counteract oxidative stress is worth to discuss further. Of particular interest in this article, we highlighted the molecular mechanisms of antioxidants involved in the prevention of age-related diseases. Taken together, a better understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity.

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Section: Role Of Antioxidants In the Prevention Of Age-related Diseasmentioning

confidence: 99%

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

et al. 2018

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“…Based on the evidence provided by both the Szejk et al (2017b) and Liu et al (2018c) , the polysaccharide-polyphenolic conjugates in Rosaceae/Asteraceae plants exhibit various biological activities, such as anticoagulation, radiation protection, anti-platelet and bronchodilatory effects. The polyphenol-polysaccharide conjugate in dried and flowering parts of S. officinalis , the anticoagulant activity of which is reportedly mediated mainly by heparin cofactor II ( Pawlaczyk-Graja et al, 2016 ), are capable of selectively protecting the normal lymphocytes from radiation damage ( Zbikowska et al, 2016 ; Szejk et al, 2017a ; Szejk-Arendt et al, 2019 ).…”

Section: Pharmacological Effects Exhibited By Genus Sanguisorbamentioning

confidence: 99%

A Comprehensive Review of Genus Sanguisorba: Traditional Uses, Chemical Constituents and Medical Applications

Zhou

Chen

et al. 2021

Front. Pharmacol.

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Genus Sanguisorba (family: Rosaceae) comprises nearly 148 species, distributed widely across the temperate and subtropical regions of the Northern Hemisphere. Sanguisorba officinalis L. (S. officinalis) has been used as a hemostatic and scald treating medicine in China for a long time. Numerous studies have demonstrated that plant extracts or monomers from S. officinalis exhibit several pharmacological effects, such as anti-cancer, anti-virus, anti-inflammation, anti-bacteria, neuroprotective and hepatoprotective effects. The other species of genus Sanguisorba are also being studied by researchers worldwide. Sanguisorba minor Scop. (S. minor), as an edible wild plant, is a common ingredient of the Mediterranean diet, and its young shoots and leaves are often mixed with traditional vegetables and consumed as salad. Reports on genus Sanguisorba available in the current literature were collected from Google Scholar, Web of Science, Springer, and PubMed. The Plant List (http://www.theplantlist.org./tpl1.1/search?q=Sanguisorba), International Plant Name Index (https://www.ipni.org/?q=Sanguisorba) and Kew Botanical Garden (http://powo.science.kew.org/) were used for obtaining the scientific names and information on the subspecies and cultivars. In recent years, several in vivo and in vitro experiments have been conducted to reveal the active components and effective monomers of S. officinalis and S. minor. To date, more than 270 compounds have been isolated and identified so far from the species belonging to genus Sanguisorba. Numerous reports on the chemical constituents, pharmacologic effects, and toxicity of genus Sanguisorba are available in the literature. This review provides a comprehensive understanding of the current traditional applications of plants, which are supported by a large number of scientific experiments. Owing to these promising properties, this species is used in the treatment of various diseases, including influenza virus infection, inflammation, Alzheimer’s disease, type 2 diabetes and leukopenia caused by bone marrow suppression. Moreover, the rich contents and biological effects of S. officinalis and S. minor facilitate these applications in dietary supplements and cosmetics. Therefore, the purpose of this review is to summarize the recent advances in the traditional uses, chemical constituents, pharmacological effects and clinical applications of genus Sanguisorba. The present comprehensive review may provide new insights for the future research on genus Sanguisorba.

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“…Polyphenolic compounds, including flavonoids, have a wide range of effects on body cells and systems, produced by plants, which are widely found in fruits and vegetables are thought to protect against ultraviolet radiation, e.g., Reference [7], decreasing the risk of carcinogenesis, complication of cardiovascular disorders, diabetes mellitus, etc., which are accompanied by oxidative stress. In addition, polyphenols are complex antioxidants with increasing public health significance, particularly in the areas of nutrition, epidemiology, and primary, secondary, and tertiary prevention [8].…”

Section: Introductionmentioning

confidence: 99%

Systematic Analysis of Combined Antioxidant and Membrane-Stabilizing Properties of Several Lamiaceae Family Kazakhstani Plants for Potential Production of Tea Beverages

Ydyrys

Zhaparkulova

Aralbaeva

et al. 2021

Plants

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One of the most important compounds that exhibit a wide range of biological activities with especially strong antioxidant action are plant polyphenols. In the course of the experiment, the dose-dependent effects of polyphenols-rich extracts isolated from the Lamiaceae family Kazakhstani plants were studied on the processes of lipid peroxidation and on the degree of erythrocytes hemolysis. The activity of aqueous-ethanolic extracts from dried parts of plants, such as Origanum vulgare, Ziziphora bungeana, Dracocephalum integrifolium, Mentha piperita, Leonurus turkestanicus, Thymus serpyllum, and Salvia officinalis, was studied in a Wistar rat model. Lipid peroxidation (LPO) in liver microsomes was assessed by measuring malondialdehyde content in the form of thiobarbituric acid-reacting substances (TBARS). Estimation of osmotic resistance of isolated erythrocytes was evaluated based on hemoglobin absorbance. The amount of total phenolics in the extracts was measured using the Folin-Ciocalteu reagent method. Based on the results, Thymus serpyllum extract exhibited a significantly higher antioxidant activity (IC50 = 3.3 ± 0.7) compared to other plant extracts. Accordingly, among the extracts studied, those from Salvia officinalis, Thymus serpyllum, and Origanum vulgare show the most pronounced membrane-stabilizing activity. Antioxidant and antihemolytic properties of green tea and Origanum vulgare extract mixtures were similar to that of each individual plant extract. Similar results were obtained when the green tea extract was mixed with Mentha piperita, Ziziphora bungeana, and Dracocephalum integrifolium extracts, indicating no discernible synergistic interaction.

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Polyphenolic–polysaccharide conjugates from plants of Rosaceae/Asteraceae family as potential radioprotectors

Cited by 22 publications

References 40 publications

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

A Comprehensive Review of Genus Sanguisorba: Traditional Uses, Chemical Constituents and Medical Applications

Systematic Analysis of Combined Antioxidant and Membrane-Stabilizing Properties of Several Lamiaceae Family Kazakhstani Plants for Potential Production of Tea Beverages

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