Polyphenol‐rich Mango (<i>Mangifera indica</i> L.) Ameliorate Functional Constipation Symptoms in Humans beyond Equivalent Amount of Fiber

Venâncio, Vinícius Paula; Kim, Hyemee; Sirven, Maritza A.; Tekwe, Carmen D.; Honvoh, Gilson; Talcott, Stephen T.; Mertens‐Talcott, Susanne U.

doi:10.1002/mnfr.201701034

Cited by 32 publications

(45 citation statements)

References 54 publications

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“…The exception was an observation of a positive association between fruit consumption and constipation. Although fruit consumption is regularly associated with decreased constipation 70,71 , we found the contradictory result. A possible explanation is that patients with constipation increased their fruit intake to prevent constipation symptoms.…”

Section: Association Between Food Group Consumption and Clinical Aspecontrasting

confidence: 63%

Differences in food consumption between patients with Hashimoto’s thyroiditis and healthy individuals

Kaličanin

Brčić

Ljubetić

et al. 2020

Sci Rep

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Food is considered as important environmental factor that plays a role in development of Hashimoto's thyroiditis (HT). The goal of our study was to identify food groups, assessed by food frequency questionnaire, that differ in consumption frequency between 491 patients with HT and 433 controls. We also analysed association of food groups with the wealth of HT-related clinical traits and symptoms. We found significantly increased consumption of animal fat (OR 1.55, p < 0.0001) and processed meat (OR 1.16, p = 0.0012) in HT cases, whereas controls consumed significantly more frequently red meat (OR 0.80, p < 0.0001), non-alcoholic beverages (OR 0.82, p < 0.0001), whole grains (OR 0.82, p < 0.0001) and plant oil (OR 0.87, p < 0.0001). We also observed association of plant oil consumption with increased triiodothyronine levels in HT patients (β = 0.07, p < 0.0001), and, association of olive oil consumption with decreased systolic blood pressure (β = − 0.16, p = 0.001) in HT patients on levothyroxine (LT4) therapy. Analysis of food consumption between HT patients with and without LT4 therapy suggest that patients do not tend to modify their diet upon HT diagnosis in our population. Our study may be of relevance to nutritionists, nutritional therapists and clinicians involved in developing dietary recommendations for HT patients. Environmental factors, in addition to genetic factors, play important role in Hashimoto's thyroiditis (HT) development 1. HT is a chronic autoimmune thyroid disorder (AITD) characterized by the production of thyroid autoantibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) 2. Other main characteristics of HT include infiltration of lymphocytes and ruination of thyroid tissue, which usually leads to hypothyroidism 3. This disease predominantly affects female population and is considered as one of the most frequent endocrine disorders 4. The estimated incidence of HT is 350/100,000 for females and 80/100,000 per year for males 5. It is most often diagnosed in women between the age of 30 and 60 6. High iodine intake (median urinary iodine concentration ≥ 300 μg/L) 7 , especially in areas with sufficient iodine supply, is one of the most known factors that increase the incidence of HT 8. Also, low vitamin D levels (below 30 ng/mL) 9 and low selenium intake (bellow 40 µg/day) 10 are proposed to be risk factors for HT development, albeit a role of these factors in HT still needs to be confirmed. Conversely, alcohol intake was proposed to decrease the risk for HT 11. Other dietary factors are also considered as potential environmental modifiers of the clinical appearance of HT 12-15. A diet low in gluten has been recently proposed to have beneficial effects on the disease course in a study of 34 women with HT 13. Another study of 83 patients with HT indicated that restriction of lactose intake in lactose-intolerant HT patients resulted with decreased thyroid-stimulating hormone (TSH) levels 14. However, the current knowledge of this topic is scarce and only the following two studies ...

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Section: Association Between Food Group Consumption and Clinical Aspecontrasting

confidence: 63%

Differences in food consumption between patients with Hashimoto’s thyroiditis and healthy individuals

Kaličanin

Brčić

Ljubetić

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In the present study, the fecal amount of acetic and propionic acids was marginally decreased in subjects with constipation. Lower amount of fecal SCFA with constipation was recognized in some previous reports [30], and a nutritional intervention, such as fiber supplementation, increased the levels of SCFA with improvement in constipation symptom [31]. In the present study, total fiber intake was not different between the constipation and control groups, but their amount of fi-ber was less than the recommended level of maintenance for good health.…”

Section: Discussion/conclusionsupporting

confidence: 51%

Gut Environment and Dietary Habits in Healthy Japanese Adults and their Association with Bowel Movement

et al. 2019

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Introduction: Constipation is a common symptom that impairs the quality of life (QOL). This study aimed to investigate the relationship between bowel movement and gut microbiota and dietary intake. Methods: To investigate correlations among bowel movement, food intake, and gut environment, 60 healthy Japanese participants were recruited. Bowel movement was assessed using the Bristol stool form scale (BSFS) and constipation scoring system (CSS). Dietary habit was assessed with a self-administered questionnaire wherein the food intake frequency was classified into 8 categories for 72 food/food groups. Gut microbiota was analyzed using terminal restriction fragment length polymorphism analysis. Results: The constipation rate was significantly higher in females than in males. The QOL was significantly impaired in the constipated group. The fecal count of Bacteroides was decreased and that of Clostridium cluster IV was increased in participants with constipation. The BSFS score was negatively associated with the fecal count of Clostridium cluster XI and positively associated with the fecal count of Clostridium cluster XVIII and consumption of green tea. The total CSS score was positively associated with the fecal Prevotella count and negatively associated with fecal acetate levels and consumption of vegetables. Discriminant analysis estimated that constipation could be predicted correctly in 83% (p < 0.001) of the participants based on fecal microbiota and fecal short-chain fatty acids. Discussion/Conclusion: Bowel movement was strongly affected by gut environment and food intake in Japanese participants. Improvement in dietary habits could promote bowel movement through the improvement of the environment in the gut, resulting in ameliorated QOL issues in healthy adults.

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“…For example, PGG extraction from more readily available sources such as Mangifera indica (mangoes) is ideal for clinical applications because the stem bark and the seeds have the same beneficial anti-oxidant traits as the fruit itself. 1,77,111,176,180,183 A comprehensive list of more than 70 plants, which can be potential sources of PGG, has been reported by Ren et al . 140 …”

Section: Functionality Of Pentagalloyl Glucosementioning

confidence: 99%

Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics

et al. 2018

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Pentagalloyl glucose (PGG) is an elastin-stabilizing polyphenolic compound that has significant biomedical benefits, such as being a free radical sink, an anti-inflammatory agent, anti-diabetic agent, enzymatic resistant properties, etc. This review article focuses on the important benefits of PGG on vascular health, including its role in tissue mechanics, the different modes of pharmacological administration (e.g., oral, intravenous and endovascular route, intraperitoneal route, subcutaneous route, and nanoparticle based delivery and microbubble-based delivery), and its potential therapeutic role in vascular diseases such as abdominal aortic aneurysms (AAA). In particular, the use of PGG for AAA suppression and prevention has been demonstrated to be effective only in the calcium chloride rat AAA model. Therefore, in this critical review we address the challenges that lie ahead for the clinical translation of PGG as an AAA growth suppressor.

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Polyphenol‐rich Mango (Mangifera indica L.) Ameliorate Functional Constipation Symptoms in Humans beyond Equivalent Amount of Fiber

Cited by 32 publications

References 54 publications

Differences in food consumption between patients with Hashimoto’s thyroiditis and healthy individuals

Differences in food consumption between patients with Hashimoto’s thyroiditis and healthy individuals

Gut Environment and Dietary Habits in Healthy Japanese Adults and their Association with Bowel Movement

Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics

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