Polyphenazine and polytriphenylmethane redox polymer/nanomaterial–based electrochemical sensors and biosensors: a review

Dalkıran, Berna; Brett, Christopher M.A.

doi:10.1007/s00604-021-04821-1

Cited by 37 publications

(14 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The electrode system quantifies the target by evaluating the charge change caused by the binding of the analyte to the electrode surface or the current or potential response caused by the redox reaction occurring on the electrode surface. The signal amplification strategies applied to electrochemical biosensors are divided into: signal amplification based on enzyme catalysis, nanomaterials, and nucleic acid [41,42].…”

Section: Electrochemical Biosensormentioning

confidence: 99%

Signal Amplification-Based Biosensors and Application in RNA Tumor Markers

Zhang

Gan

et al. 2023

Sensors

View full text Add to dashboard Cite

Tumor markers are important substances for assessing cancer development. In recent years, RNA tumor markers have attracted significant attention, and studies have shown that their abnormal expression of post-transcriptional regulatory genes is associated with tumor progression. Therefore, RNA tumor markers are considered as potential targets in clinical diagnosis and prognosis. Many studies show that biosensors have good application prospects in the field of medical diagnosis. The application of biosensors in RNA tumor markers is developing rapidly. These sensors have the advantages of high sensitivity, excellent selectivity, and convenience. However, the detection abundance of RNA tumor markers is low. In order to improve the detection sensitivity, researchers have developed a variety of signal amplification strategies to enhance the detection signal. In this review, after a brief introduction of the sensing principles and designs of different biosensing platforms, we will summarize the latest research progress of electrochemical, photoelectrochemical, and fluorescent biosensors based on signal amplification strategies for detecting RNA tumor markers. This review provides a high sensitivity and good selectivity sensing platform for early-stage cancer research. It provides a new idea for the development of accurate, sensitive, and convenient biological analysis in the future, which can be used for the early diagnosis and monitoring of cancer and contribute to the reduction in the mortality rate.

show abstract

Section: Electrochemical Biosensormentioning

confidence: 99%

Signal Amplification-Based Biosensors and Application in RNA Tumor Markers

Zhang

Gan

et al. 2023

Sensors

View full text Add to dashboard Cite

show abstract

“…27 Alternatively, redox polymers (e.g., polyphenazines, polytriphenylmethane) have nonconducting backbones and redox moieties as side chains that facilitate electron transfer to the electrode via self-exchange mechanisms; however, they are distinguished by moieties that are not semiconductive, but rather chemically reduced and oxidized. 28 Electrodes modified with redox polymers may experience hindrance in the conduction of electrons due to the indirect, electron-hopping mechanism between the redox moieties in the RP. Conducting redox polymers (CRPs) have emerged as a hybrid strategy to streamline the electron transfer pathway between these redox sites, increasing the current signal achieved.…”

Section: Materials Strategies Can Improve Figures Of Meritmentioning

confidence: 99%

“…Conductive polymers (e.g., polypyrroles, polyanilines, polythiophenes) have conjugated backbones and are electrically semiconductive and known to form highly stable films . Alternatively, redox polymers (e.g., polyphenazines, polytriphenylmethane) have nonconducting backbones and redox moieties as side chains that facilitate electron transfer to the electrode via self-exchange mechanisms; however, they are distinguished by moieties that are not semiconductive, but rather chemically reduced and oxidized . Electrodes modified with redox polymers may experience hindrance in the conduction of electrons due to the indirect, electron-hopping mechanism between the redox moieties in the RP.…”

Section: Introductionmentioning

confidence: 99%

Materials Approaches for Improving Electrochemical Sensor Performance

Beaver

Dantanarayana

2021

J. Phys. Chem. B

View full text Add to dashboard Cite

Electrochemical sensors have emerged as important diagnostic tools in recent years, due to their simplicity and ease of use. Compared to instrumental analysis methods that use complicated experimental and data analysis techniquessuch as mass spectrometry, nuclear magnetic resonance (NMR), spectrophotometric methods, and chromatography electrochemical sensors show promise for use in a wide range of real-time and in situ applications such as pharmaceutical testing, environmental monitoring, and medical diagnostics. In order to identify analytes in complex and/or biological samples, materials used for both the electrode materials and the chemically selective layer have been evolving throughout the years for optimizing the analytical performance of electrochemical sensors to increase sensitivity, selectivity and linear range. In this Perspective, attention will be focused on different types of materials that have been used for electrochemical sensing, including new combinations of well-studied materials as well as novel strategies to enhance the performance of sensing devices. The Perspective will also discuss existing challenges in the field and future strategies for addressing those challenges.

show abstract

“…Redox-active and electroconductive polymers are widespread in biosensor assemblies [26,27]. They convert the biorecognition event to the electrical signal (current or charge transfer resistance).…”

Section: Introductionmentioning

confidence: 99%

One-Step Electropolymerization of Azure A and Carbon Nanomaterials for DNA-Sensor Assembling and Doxorubicin Biosensing

Porfireva

Begisheva

Rogov

et al. 2022

View full text Add to dashboard Cite

New highly sensitive voltammetric DNA-sensors have been developed for the detection of cytostatic drug doxorubicin based on Azure A electropolymerized on various carbon nanomaterials, i.e., functionalized multi-walled carbon nanotubes (fMWCNTs) and carbon black (CB). Carbon materials promote electropolymerization of the Azure A dye applied as a matrix for DNA molecules saturated with methylene blue (MB) molecules. Interaction with the intercalator (doxorubicin) liberates the MB molecules and changes redox activity. The doxorubicin concentration ranges reached by cyclic voltammetry were from 0.1 pM to 100 nM (limit of detection, LOD, 0.03 pM) for the biosensor based on CB, and from 0.3 pM to 0.1 nM (LOD 0.3 pM) for that based on fMWCNTs. DNA-sensors were tested on spiked samples of artificial serum, and biological and pharmaceutical samples. The DNA-sensors can find further application in the monitoring of the doxorubicin residuals in cancer treatment, as well as for pharmacokinetics studies.

show abstract

Polyphenazine and polytriphenylmethane redox polymer/nanomaterial–based electrochemical sensors and biosensors: a review

Cited by 37 publications

References 82 publications

Signal Amplification-Based Biosensors and Application in RNA Tumor Markers

Signal Amplification-Based Biosensors and Application in RNA Tumor Markers

Materials Approaches for Improving Electrochemical Sensor Performance

One-Step Electropolymerization of Azure A and Carbon Nanomaterials for DNA-Sensor Assembling and Doxorubicin Biosensing

Contact Info

Product

Resources

About