2013
DOI: 10.4103/0973-1229.104497
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Abstract: Psychiatric polypharmacy refers to the prescription of two or more psychiatric medications concurrently to a patient. It can be categorised as same-class, multi-class, adjunctive, augmentation and total polypharmacy. Despite advances in psychopharmacology and a better understanding of the principles of therapeutics, its practice is increasing rapidly. The prevalence of polypharmacy in psychiatry varies between 13%-90%. There are various clinical and pharmaco-economic factors associated with it. Dealing with po… Show more

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Cited by 87 publications
(51 citation statements)
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References 47 publications
(55 reference statements)
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“…Possible causes underlying other substances' positive associations with both SSRI exposure and non-violent suicide might include the following: SSRIs are often prescribed together with other medications that may represent a lethal means of self-harm; and other substances may exert a negative influence on violent behavior. Antidepressants are the most commonly co-prescribed drugs in multi-class polypharmacy for psychiatric disorders, which furthermore have high co-morbidity rates with both somatic illness and substance misuse [27][28][29][30]. In this context, apart from intentional self-poisoning being the predominant non-violent suicide method, the biological effects of other substances may also have diminished subjects' impulsivity and aggressiveness, ultimately influencing the choice of suicide method.…”
Section: Discussionmentioning
confidence: 99%
“… 1 These rates increase to 13% in general population and an alluring 90% in general psychiatric settings. 2 Polypharmacy point prevalence rates up to 40% (according to the definition of three or more medications at once) or 18% (in case of four or more concomitant medications) have been reported for bipolar disorder (BD) cases suffering from long-lasting and/or treatment-resistant depression and receiving antidepressant drugs. 3 Furthermore, most of the available information about psychiatric medications comes from drug development programs that lead to registration and marketing.…”
Section: Introductionmentioning
confidence: 99%
“…Pharmacotherapy prescribing patterns, bipolar disorder monotherapy and management of side effects (Goodwin et al 2009;Kukreja, Kalra Shah & Shrivastava 2013;Tohen et al 2002;Post 2004). Whilst the evidence for polypharmacy and combination treatment is limited, the use in clinical practice is common (Solomon et al 1996), noting that not all patients with bipolar disorder can be stabilised with monotherapy and that polypharmacy and combination treatment is increasingly used to manage these patients in clinical practice (Goldberg et al 2009;Tohen et al 2002;Post 2004;Solomon et al 1996;Gever 2010;Ventimiglia, Kalali & McIntyre 2009;Baldessarini et al 2007;Post et al 2010;Hooshmand et al 2014).…”
mentioning
confidence: 99%
“…Whilst the evidence for polypharmacy and combination treatment is limited, the use in clinical practice is common (Solomon et al 1996), noting that not all patients with bipolar disorder can be stabilised with monotherapy and that polypharmacy and combination treatment is increasingly used to manage these patients in clinical practice (Goldberg et al 2009;Tohen et al 2002;Post 2004;Solomon et al 1996;Gever 2010;Ventimiglia, Kalali & McIntyre 2009;Baldessarini et al 2007;Post et al 2010;Hooshmand et al 2014). Clinicians, however, need to be mindful that the use of polypharmacy and combination treatment is therapeutic and rational and where possible evidence based (Kukreja, Kalra Shah & Shrivastava 2013).…”
mentioning
confidence: 99%
“…However, using two or more medications to treat the same condition, or using two or more drugs belonging to the same class, or using two or more drugs with similar actions, is accepted as polypharmacy. 5,6 Prescribing multiple medications to a patient increases the complexity of the treatment regimen and the chances of adverse effects. This could have an adverse impact with respect to the compliance to treatment.…”
Section: Introductionmentioning
confidence: 99%