“… α-SMA, Col-I, desmin, vimentin, Smo, Gli2 and, DNMT1↓ | ( Yu et al, 2015 ) | E-cadherin, PTCH1↑ |
Liver cirrhosis (rat) | DMN | 12.5 mg/kg (i.g.) | ALT, AST, bilirubin, Hyp | ( Xu et al, 2012 ) |
In vitro |
HSC-T6 cells | PDGF | 200, 300, 400 μ M | HO-1, Nuclear factor E2-related factor 2, p-JNK, p-p38, Trx, p-PKC-δ, p-PKD↓ | ( Tsai et al, 2011 ) |
HSC-T6 cells | PDGF | 200 μ M | ROS, α-SMA, gp91 phox , p47 phox ↓ | ( Tsai et al, 2010 ) |
Primary rat HSCs | TGF-β1 | 1, 10 µM | α-SMA, TβR-I, T[1]II, TβRI, Smad3, p-Smad3↓ | ( Tao et al, 2013 ) |
Primary rat HSCs | TGF-β1 | 10 μ M | α-SMA, Col-I, p-MEK, p-ERK, p-Raf, p-p38, MEF2C, MEF2A, p-MKK3/6↓ | ( Lv et al, 2010 ) |
ERK and p38 MAPK signaling pathways↓ |
Primary mouse HSCs | - | 10 μ M | α-SMA, Col-I, desmin, vimentin, Smo, Gli2, DNMT1↓ | ( Yu et al, 2015 ) |
Caspase3, E-cadherin, PTCH1↑ |
MRC5 cells | ... |
…”