Polypeptide uploaded efficient nanophotosensitizers to overcome photodynamic resistance for enhanced anticancer therapy

Li, Yanjing; Zhou, Ronghui; Xiao, Dexuan; Shi, Sirong; Peng, Shuanglin; Wu, Shihong; Wu, Peng; Lin, Yunfeng

doi:10.1016/j.cej.2020.126344

Cited by 24 publications

(15 citation statements)

References 56 publications

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“…RNA extraction and cDNA acquisition and purification were performed as described in our previous studies [ 30 , 31 ]. RT-PCR was performed using SYBR® Green I PCR master mix in an ABI QuantStudio 6 Real-Time PCR System (Thermo Scientific, USA).…”

Section: Methodsmentioning

confidence: 99%

Tetrahedral Framework Nucleic Acid-Based Delivery of Resveratrol Alleviates Insulin Resistance: From Innate to Adaptive Immunity

Gao

Shi

et al. 2021

Nano-Micro Lett.

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Obesity-induced insulin resistance is the hallmark of metabolic syndrome, and chronic, low-grade tissue inflammation links obesity to insulin resistance through the activation of tissue-infiltrating immune cells. Current therapeutic approaches lack efficacy and immunomodulatory capacity. Thus, a new therapeutic approach is needed to prevent chronic inflammation and alleviate insulin resistance. Here, we synthesized a tetrahedral framework nucleic acid (tFNA) nanoparticle that carried resveratrol (RSV) to inhibit tissue inflammation and improve insulin sensitivity in obese mice. The prepared nanoparticles, namely tFNAs-RSV, possessed the characteristics of simple synthesis, stable properties, good water solubility, and superior biocompatibility. The tFNA-based delivery ameliorated the lability of RSV and enhanced its therapeutic efficacy. In high-fat diet (HFD)-fed mice, the administration of tFNAs-RSV ameliorated insulin resistance by alleviating inflammation status. tFNAs-RSV could reverse M1 phenotype macrophages in tissues to M2 phenotype macrophages. As for adaptive immunity, the prepared nanoparticles could repress the activation of Th1 and Th17 and promote Th2 and Treg, leading to the alleviation of insulin resistance. Furthermore, this study is the first to demonstrate that tFNAs, a nucleic acid material, possess immunomodulatory capacity. Collectively, our findings demonstrate that tFNAs-RSV alleviate insulin resistance and ameliorate inflammation in HFD mice, suggesting that nucleic acid materials or nucleic acid-based delivery systems may be a potential agent for the treatment of insulin resistance and obesity-related metabolic diseases.

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Section: Methodsmentioning

confidence: 99%

Tetrahedral Framework Nucleic Acid-Based Delivery of Resveratrol Alleviates Insulin Resistance: From Innate to Adaptive Immunity

Gao

Shi

et al. 2021

Nano-Micro Lett.

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“…Recent evidence suggests that tFNA, a special DNA nanodevice, which has been widely used in diverse biomedical fields, might be a powerful tool that could be helpful in the treatment of NDs (Li et al, 2021b;Li et al, 2021c). Here, this minireview concludes the development and use of tFNA, which is highly applied DNA nanostructure with unique characteristics, flexible penetration, precise programmability and susceptibility to biological regulation (Sirong et al, 2020;Sun et al, 2021).…”

Section: Introductionmentioning

confidence: 96%

Application of Programmable Tetrahedral Framework Nucleic Acid-Based Nanomaterials in Neurological Disorders: Progress and Prospects

Chen

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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Tetrahedral framework nucleic acid (tFNA), a special DNA nanodevice, is widely applied in diverse biomedical fields. Due to its high programmability, biocompatibility, tissue permeability as well as its capacity for cell proliferation and differentiation, tFNA presents a powerful tool that could overcome potential barriers in the treatment of neurological disorders. This review evaluates recent studies on the use and progress of tFNA-based nanomaterials in neurological disorders.

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“…Recently, with the development of nanotechnology, nanoparticle‐based cancer diagnosis and therapy has attracted much attention. 6 , 7 , 8 , 9 , 10 , 11 Many nanoparticles have been employed to improve the delivery efficiency and sustained release of DTX, such as gold nanorods, 12 poly(lactide‐co‐glycolide) (PLGA), 13 mesoporous CuS, 14 and mesoporous silica nanoparticles. 15 , 16 Mesoporous polydopamine (MPDA), spontaneously polymerized by dopamine, displays striking properties in optics, electricity, magnetics, biocompatibility, and biodegradability and has gained much attention for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Aptamer‐conjugated mesoporous polydopamine for docetaxel targeted delivery and synergistic photothermal therapy of prostate cancer

et al. 2021

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Prostate cancer is one of the most common cancer among men and is the most frequently diagnosed cancer in more developed countries. 1 According to the clinical scenario of the patient, surgical or nonsurgical treatments are available as curative therapy concepts, such as surgery, chemotherapy, radiation therapy, androgen deprivation therapy, and active surveillance. Although some improvements have been made in the treatments, nearly all diagnostic and therapeutic approaches for prostate cancer still rely on highly invasive and nonspecific techniques.Radical prostatectomy or radiotherapy are two main curative forms of therapy and are beneficial for the mortality of prostate cancer, however, surgery and radiation may result in serious outcome of incontinence and erectile dysfunction. 2,3 Chemotherapy is naturally palliative in the early

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Polypeptide uploaded efficient nanophotosensitizers to overcome photodynamic resistance for enhanced anticancer therapy

Cited by 24 publications

References 56 publications

Tetrahedral Framework Nucleic Acid-Based Delivery of Resveratrol Alleviates Insulin Resistance: From Innate to Adaptive Immunity

Tetrahedral Framework Nucleic Acid-Based Delivery of Resveratrol Alleviates Insulin Resistance: From Innate to Adaptive Immunity

Application of Programmable Tetrahedral Framework Nucleic Acid-Based Nanomaterials in Neurological Disorders: Progress and Prospects

Aptamer‐conjugated mesoporous polydopamine for docetaxel targeted delivery and synergistic photothermal therapy of prostate cancer

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