Polymyositis/dermatomyositis and pregnancy

Abstract

Eighteen women with polymyositis/dermatomyositis (PM/DM) were studied to determine the possible influences of pregnancy on the disease and the influence of the disease on pregnancy. Before the onset of PM/DM there were 77 pregnancies: 7 (9%) ended in abortion, 2 (2.5%) in perinatal deaths, with a total fetal loss of 11.5%. There were 3 (3.8%) premature newborns that survived. These figures are equivalent to those of the general population. There were 10 pregnancies in 7 patients coinciding with PM/DM, 1 of them with twins; 3 (30%) ended in abortion, 3 (25%) in perinatal deaths, with a total fetal loss of 55%, and 5 (50%) pregnancies ended prematurely. Four of the 7 women had onset of PM/DM during pregnancy, and 3 others with previously inactive disease had an exacerbation during pregnancy. There were no maternal deaths, nor was there any correlation between activity of PM/DM and fetal loss. These results together with those previously reported suggest that pregnancy in PM/DM should be considered high-risk for both the mother and the baby.In recent years with the development of modern fetal and neonatal monitoring and care, and with maternal control (1,2), it has been possible to reduce

Successful Outcomes of Pregnancy Complicated with Dermatomyositis

“…It is evident, therefore, that women in the reproductive age group are somewhat spared from the disease, and there is relatively little infor mation concerning the outcome of pregnancy in patients with DM, compared with other connective tissue diseases including rheumatoid arthritis and systemic lupus erythe matosus [2,4]. In contrast with previous reports on increased incidence of exacerbation throughout preg nancy and puerperium [5][6][7][8][9][10], the patients described below introduced 2 cases of successful outcomes of preg nancy complicated with DM.…”

Gravidez em adolescentes com dermatomiosite juvenil (DMJ)

“…As taxas de fertilidade da DM ou PM podem estar diminuídas. A redução da função gonadal ovariana pode ocorrer pela própria atividade da doença crônica e/ou uso dos imussupressores (15) . Por sua vez, King e Chow (7) reportaram uma incidência de mulheres nulíparas de 12% em 78 pacientes com DM/PM; esses dados foram semelhantes aos encontrados na população geral.…”

Myositis and Pregnancy

“…Both reports looked at very small groups of patients who developed IIM before or during their childbearing years. One concluded that there was an incidence of nulliparity comparable to the general population [ 2 ] while the other concluded that there was a reduction in the fertility rate [ 3 ]. The small sample sizes make it impossible to have confi dence in either conclusion.…”