Polymorphous low-grade adenocarcinoma of the head and neck

Paleri, Vinidh; Robinson, Max; Bradley, Patrick

doi:10.1097/moo.0b013e3282f70441

Cited by 48 publications

(46 citation statements)

References 52 publications

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“…[9] Tubular structures are lined by a single cell layer and resemble terminal ducts. [10] Cells often assume a linear, single-cell arrangement at the tumor periphery known as "Indian file" or "beads on a string" pattern of infiltration. [10,11] Necrosis is, at most, extremely rare and mitotic figures are infrequent and never atypical.…”

Section: Introductionmentioning

confidence: 99%

“…[10] Cells often assume a linear, single-cell arrangement at the tumor periphery known as "Indian file" or "beads on a string" pattern of infiltration. [10,11] Necrosis is, at most, extremely rare and mitotic figures are infrequent and never atypical. PLGA invades nerves in about 30% of cases, often in a so-called targetoid arrangement, with cords of cells concentrically arranged around nerves.…”

Section: Introductionmentioning

confidence: 99%

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Nano-hydroxyapatite and its contemporary applications

Kantharia¹,

Naik²,

Apte³

et al. 2014

J Dent Res Sci Develop

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Polymorphous low-grade adenocarcinoma (PLGA) is difficult to diagnose due to its indolent clinical presentation and due to its morphological diversity that includes several microscopic patterns. Distinguishing it from high-grade tumors of salivary gland is important, as the management and prognosis of this tumor differ. We report a considerably rare case of PLGA in retromolar area highlighting various diagnostic challenges caused by the overlap of clinical and microscopic features between PLGA and other salivary gland neoplasms and discuss current management strategies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nano-hydroxyapatite and its contemporary applications

Kantharia¹,

Naik²,

Apte³

et al. 2014

J Dent Res Sci Develop

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“…Les lèvres sont touchées dans 13 % des cas, suivies de la muqueuse orale dans 10 % des cas et plus rarement de la région rétro-molaire, du plancher oral et de la langue. Les glandes salivaires principales restent un siège exceptionnel de l'APBG de même que les fosses nasales et le nasopharynx (0,5 à 1 % des cas) [8,9].…”

Section: Discussionunclassified

Adénocarcinome polymorphe de bas grade du palais mou : revue et rapport de cas

Naji

Alaoui

Yahya

2016

Med Buccale Chir Buccale

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Résumé -Introduction : L'adénocarcinome polymorphe de bas grade (APBG) est une tumeur maligne rare qui se trouve presque exclusivement située dans les glandes salivaires accessoires. Il survient fréquemment chez les patients entre 30 et 70 ans, avec un ratio femme-homme de 2/1. Il est généralement situé dans le palais dur ou mou. Observation : Il s'agissait d'une patiente de 38 ans, consultant suite à l'apparition d'une tuméfaction bleutée au niveau du palais mou droit, évoluant depuis un an, indolore et recouverte d'une muqueuse d'aspect normal. Le diagnostic évoqué était un adénome pléomorphe mais l'examen histologique après exérèse chirurgicale révélait un APBG. Une reprise des marges d'exérèse était nécessaire associée à une plastie. Discussion : Le diagnostic de l'APBG est basé principalement sur les éléments cliniques et radiologiques. L'anatomopathologie permet la confirmation et la classification de la lésion. Le traitement reste essentiellement chirurgical. Le pronostic est bon malgré un taux de récidive de l'ordre de 17 % à 24 %. Bien que rares, les métastases dans les ganglions lymphatiques régionaux peuvent se produire dans 9 % des cas. Conclusion : L'APBG est une tumeur non agressive dont le pronostic dépend de plusieurs facteurs dont le délai de consultation, d'où l'importance d'un dépistage précoce.Abstract -Polymorphous low-grade adenocarcinoma of the soft palate: review and case report. Introduction: Polymorphous low-grade adenocarcinoma (PLGA) is a rare malignant tumor that is found almost exclusively in the minor salivary glands. It frequently occurs in patients between 30 and 70 years old, with a female to male ratio of 2/1. It is usually located in the hard or soft palate. Observation: A 38-year-old female patient presented with a bluish swelling in the right side of the soft palate which had evolved for a year, which was painless and covered with a mucosa of normal appearance. The first diagnosis suggested was pleomorphic adenoma, but the histologic exam following the surgical biopsy revealed a PLGA. Surgical revision of the safety margins was necessary together with mucosal plasty. Discussion: The diagnosis of PLGA is based mainly on clinical and radiological aspects, but a histologic exam is absolutely necessary to confirm it, and for classification of the lesion. Treatment is mainly surgical. The prognosis is good, although the recurrence rate is 17% to 24%. Although seldom, metastases in regional lymph nodes may occur in 9% of cases. Conclusion: PLGA is a non-aggressive tumor whose prognosis depends on several factors including the consultation period. This highlights the importance of early detection.

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“…Clinically, PLGA usually has an indolent course and distant metastases are uncommon at the time of diagnosis (2). PLGA are almost exclusively found in the oral cavity, particularly in the palate, upper lip and buccal mucosa (3). It is the second most common intraoral salivary gland carcinoma.…”

Section: Introductionmentioning

confidence: 99%

“…The two main differential diagnoses are adenoid cystic carcinoma (ACC) and pleomorphic adenoma. PLGA is typically characterized by morphologic diversity, cytologic uniformity and an infiltrative growth pattern (3,4). A variety of growth patterns may be observed both between tumors and within individual tumors, including cribriform, lobular, trabecular, papillary, papillary-cystic or small duct-like structures.…”

Section: Introductionmentioning

confidence: 99%

Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck

Persson

Fehr²,

Sundelin³

et al. 2011

Int J Oncol

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Abstract. Polymorphous low-grade adenocarcinoma (PLGA) is a malignancy predominantly originating from the minor salivary glands. The molecular events underlying the pathogenesis of PLGA is poorly understood and no recurrent genetic aberrations have so far been identified. We used genome-wide, high-resolution aCGH analysis to explore genomic imbalances in 9 cases of PLGA. Because of the well-known morphologic similarities between PLGA and adenoid cystic carcinoma (ACC) we also analyzed all tumors for expression of the recently identified ACC-associated MYB-NFIB gene fusion. aCGH analysis revealed that the PLGA genome contains comparatively few copy number alterations (CNAs). Gains/ losses of whole chromosomes or chromosome arms were more than twice as common as partial CNAs. Two cases showed gain of chromosome 8 and one case each gain of chromosome 9, loss of chromosome 22 and loss of the Y chromosome. One case showed loss of the entire 6q arm and one case an interstitial deletion of a 33-Mb segment within 6q22.1-q24.3. This region contains the MYB oncogene and the candidate tumor suppressor gene PLAGL1. RT-PCR analysis revealed that one of the 9 PLGAs expressed the ACC-associated MYB-NFIB gene fusion, illustrating the diagnostic difficulties associated with the diagnosis of these morphologically partly overlapping entities. Taken together, our findings indicate that the PLGA genome is genetically stable and contains comparatively few CNAs which is in line with the clinical observation that PLGA is a slow-growing, low-grade carcinoma with low metastatic potential.

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Polymorphous low-grade adenocarcinoma of the head and neck

Abstract: Polymorphous low-grade adenocarcinoma is primarily a pathologic diagnosis. Surgical resection is the mainstay of treatment. Long-term follow-up of 10 years or more is essential to ensure local control.

Cited by 48 publications

References 52 publications

Nano-hydroxyapatite and its contemporary applications

Nano-hydroxyapatite and its contemporary applications

Adénocarcinome polymorphe de bas grade du palais mou : revue et rapport de cas

Studies of genomic imbalances and the MYB-NFIB gene fusion in polymorphous low-grade adenocarcinoma of the head and neck

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