Polymorphonuclear Neutrophils Are Necessary for the Recruitment of CD8+T Cells in the Liver in a Pregnant Mouse Model ofChlamydophila abortus(Chlamydia psittaciSerotype 1) Infection

de, Roberto Montes; Buendía, A. J.; Rı́o, Laura Del; Sánchez, J.; Salinas, J.; Navarro, J. A.

doi:10.1128/iai.68.3.1746-1751.2000

Cited by 53 publications

(29 citation statements)

References 30 publications

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“…It would be valuable to determine if these players interact with each other and to identify the mechanisms underlying interactions. Neutrophils are demonstrated to be necessary for recruitment, priming and activation of CD8 + T cells in different inflammatory models [41,42]. In turn, CD11b + CD8 + T cells can activate polymorphonuclear neutrophils via production of IFN-c [48].…”

Section: Peritumor (Cut-off 50%mentioning

confidence: 98%

“…Neutrophils are demonstrated to be necessary for recruitment, priming, and activation of CD8 + T cells in different inflammatory models [41,42]. Similarly, this interplay between innate and adaptive immunity, determined as peripheral neutrophilto-lymphocyte ratio (NLR) of systemic immune response, has been correlated with poor prognosis in various cancer types 83 18 47 54 53 48 80 21 59 42 65 36 60 41 51 50 53 48 33 68 12 36 76 20 50 46 7 89 10 86 31 65 81 15 46 50 58 38 76 20 48 48 54 42 67 29 52 44 58 38 40 56 7 (Cut-off 50%) 82 17 58 41 9 90 12 87 38 61 83 16 44 55 53 46 78 21 60 39 62 37 63 36 52 47 57 42 37 62 9 31 83 15 46 52 4 94 11 87 35 63 81 17 49 49 58 40 78 20 47 51 57 41 64 34 51 47 54 44 36 62 10 …”

Section: (E) Distribution Of Intratumoral Cd66b + Neutrophils and Cd8mentioning

confidence: 99%

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Intratumoral neutrophils: A poor prognostic factor for hepatocellular carcinoma following resection

Li¹,

Qiu²,

Fan³

et al. 2011

Journal of Hepatology

246

194

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Section: Peritumor (Cut-off 50%mentioning

confidence: 98%

Section: (E) Distribution Of Intratumoral Cd66b + Neutrophils and Cd8mentioning

confidence: 99%

Intratumoral neutrophils: A poor prognostic factor for hepatocellular carcinoma following resection

Li¹,

Qiu²,

Fan³

et al. 2011

Journal of Hepatology

246

194

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“…A previous study in mice using anti-Ly6G/C (clone RB6-8C5), which binds not only neutrophils but also subsets of monocytes, dendritic cells, and CD8 ϩ T cells, detected no alteration in the course of infection but did reveal reduced rates of hydrosalpinx resulting from C. muridarum genital tract infection (10,25,28,45). Although the authors detected a significant decrease in MMP9 levels, no reduction in acute inflammation was observed in the oviducts, suggesting a lack of specificity for the outcome (25).…”

Section: Discussionmentioning

confidence: 99%

Enhanced Neutrophil Longevity and Recruitment Contribute to the Severity of Oviduct Pathology during Chlamydia muridarum Infection

Frazer

O’Connell

Andrews³

et al. 2011

Infect Immun

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Our previous studies revealed that intravaginal infection of mice with a plasmid-deficient strain of Chlamydia muridarum, CM3.1, does not induce the development of oviduct pathology. In this study, we determined that infection with CM3.1 resulted in a significantly reduced frequency and absolute number of neutrophils in the oviducts during acute infection. This reduction in neutrophils was associated with significantly lower levels of neutrophil chemokines in the oviducts and decreased production of neutrophil chemokines by oviduct epithelial cells infected with CM3.1 in vitro. Infection with CM3.1 also resulted in an increased frequency of late apoptotic/dead neutrophils in the oviduct. Examination of the ability of Chlamydia trachomatis to prevent neutrophil apoptosis in vitro revealed that C. trachomatis strain D/UW-3/Cx exhibited an enhanced ability to prevent neutrophil apoptosis compared to plasmid-deficient CTD153, and this effect was dependent on the presence of CD14 high monocytes. The presence of monocytes also resulted in enhanced neutrophil cytokine production and increased production of tissue-damaging molecules in response to D/UW-3/Cx relative to results with CTD153. Attempts to use antibody-mediated depletion to discern the specific role of neutrophils in infection control and pathology in vivo revealed that although Ly6G high neutrophils were eliminated from the blood and oviducts with this treatment, immature neutrophils and high levels of tissue-damaging molecules were still detectable in the upper genital tract. These data support the role of neutrophils in chlamydia-induced pathology and reveal that novel methods of depletion must be developed before their role can be specifically determined in vivo.Chlamydia trachomatis represents the most common bacterial sexually transmitted infection in the world, with WHO estimates indicating that 90 million individuals are infected worldwide (48). Acute infection is often asymptomatic, but untreated or repeat infections can result in immunopathology including pelvic inflammatory disease (PID), chronic pelvic pain, ectopic pregnancy, and infertility. This pathology results from an aggressive host inflammatory response, and human studies have provided insight into potential inflammatory mediators of reproductive tract sequelae. A study examining endometrial biopsy specimens from women exhibiting signs of PID correlated C. trachomatis infection with an inflammatory milieu consisting of both acute and chronic leukocyte populations, including neutrophils, plasma cells, and periglandular lymphoid follicles containing transformed lymphocytes (21). In patients with documented endometrial and oviduct infection with C. trachomatis, neutrophils were observed infiltrating the glandular epithelium (21). A separate study of women at risk for PID associated the presence of increased vaginal levels of neutrophil alpha defensins, a marker of neutrophil activation, with the development of endometritis due to C. trachomatis infection (47).Although studies in humans have ...

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“…Polymorphonuclear neutrophils have been shown to be necessary for the recruitment of CD8 + T cells in a mouse model of C. psittaci infection [46]. Moreover, EBs and RBs can be found inside infiltrating neutrophils [47].…”

Section: Potential Contribution Of Other Immune Components To the mentioning

confidence: 99%

Role of CD8+T cells in the host response to Chlamydia

Wizel

Nyström-Asklin

Cortés

et al. 2008

Microbes and Infection

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Chlamydia infections constitute a major public health problem. Although multiple arms of the immune system participate in the control of Chlamydia in infected hosts, T lymphocytes are essential. This review focuses on the roles that CD8 + T cells may play in immunoprotection and immunopathology following recognition of Chlamydia-infected cells. KeywordsChlamydia; CD8 + T cells IntroductionMembers of the Chlamydiaceae family are obligate intracellular gram-negative bacteria that include the human pathogens Chlamydia trachomatis (Ct) and Chlamydia pneumoniae (Cpn). While Ct is responsible for ocular and sexually transmitted diseases that can result in blindness and infertility, Cpn is a common cause of upper respiratory infections and pneumonia and has been associated with several chronic inflammatory conditions such as atherosclerosis and chronic obstructive pulmonary disease (COPD) [1][2][3]. When diagnosed early, Chlamydia infections can be treated with antibiotics. However, the high costs required to identify and treat individuals with mild or no symptoms limits the feasibility of this control strategy. Moreover, hosts can remain chronically infected despite chemotherapy, and some antibiotics may induce chlamydial persistence [4]. Thus, development of safe and effective vaccines represents a cost-effective approach that would have a greater impact on the high prevalence of Chlamydia infections and the prevention of severe long-term sequelae.Like all chlamydiae, Ct and Cpn have a unique biphasic developmental cycle alternating between an infectious metabolically inert elementary body (EB) and a replicating metabolically active reticulate body (RB). After entry into susceptible cells such as epithelial cells, macrophages, endothelial and smooth muscle cells, the EB remains within a nonacidified vacuole known as an inclusion, where it differentiates into a RB, which replicates by binary fission. The generated progeny differentiate back into EBs that are then released upon host cell lysis to infect other cells. Under certain conditions, however, Chlamydia enters a persistent non-replicating stage but remains capable of resuming a productive cycle when the adverse *Corresponding author. Current mailing address: Intercell AG, Campus Vienna Biocenter 6, 1030 Wien, Austria. Phone: +43-1-20620-174. Fax: +43-1-20620-805. E-mail: bwizel@intercell.com. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Evidence of a role for CD8 + T cells in the immune control of ChlamydiaAn intact T cell compartment is required for resistance against Chlamydia infection. T ...

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Polymorphonuclear Neutrophils Are Necessary for the Recruitment of CD8⁺T Cells in the Liver in a Pregnant Mouse Model ofChlamydophila abortus(Chlamydia psittaciSerotype 1) Infection

Cited by 53 publications

References 30 publications

Intratumoral neutrophils: A poor prognostic factor for hepatocellular carcinoma following resection

Intratumoral neutrophils: A poor prognostic factor for hepatocellular carcinoma following resection

Enhanced Neutrophil Longevity and Recruitment Contribute to the Severity of Oviduct Pathology during Chlamydia muridarum Infection

Role of CD8+T cells in the host response to Chlamydia

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