Polymorphisms of the DNA Repair Gene XPA and XPC and its Correlation With Gastric Cardiac Adenocarcinoma in a High Incidence Population in North China

Zhao, Dong; Guo, Wei; Zhou, Rong‐Miao; Lingling, Wan; Yan, Li; Wang, Na; Kuang, Gang; Wang, Shijie

doi:10.1097/mcg.0b013e3180f6262c

Cited by 37 publications

(35 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As studies with the same population by different investigators or overlapping data by the same authors were found, the most recent or complete articles with the largest numbers of subjects were included. 14,17,36 All eligible studies were examined carefully, and their bibliographies were checked for other relevant publications.…”

Section: Identification and Eligibility Of Relevant Studiesmentioning

confidence: 99%

“…5 To date, a number of molecular epidemiological studies have been done to evaluate the association between XPA À4G>A polymorphism and different types of cancer risk in diverse populations. The tumor types included lung cancer, 6,13,22,24,[29][30][31][32][33][34] gastric cancer, 7,17 colorectal cancer, 8,12,23 squamous cell carcinoma of the head and neck, 8,10 basal and squamous cell carcinomas of the skin (BCC and SCC), 20,27 breast cancer, 8,18,26 esophageal cancer, 11,14,15 and so on. However, the results were inconsistent or even contradictory.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Genetic variation of XPA gene and risk of cancer: A systematic review and pooled analysis

Ding

Zhang

et al. 2011

Intl Journal of Cancer

View full text Add to dashboard Cite

XPA, a zinc-finger DNA-binding protein, play an important role in both global genome and transcription-coupled repair pathways. XPA 24G>A polymorphism was identified in the 5 0 noncoding region, located four nucleotides upstream of the ATG start codon. Previous studies have shown that this polymorphism may affect mRNA tertiary structure and stability and play a role in susceptibility to cancer. However, the results remained controversial. To derive a more precise estimation of association between this polymorphism and risk of different types of cancer, we performed a meta-analysis based on 36 case-control or case-cohort studies, including a total of 11,700 cases and 15,033 controls. We used odds ratios with 95% confidence intervals to assess the strength of the association. Overall, no significantly elevated cancer risk was found in all genetic models when eligible studies were pooled into the meta-analysis. In the stratified analyses, we found that individuals with A-allele had a higher risk of lung cancer (AA versus GG: OR 5 1.25, 95% CI 5 1.09-1.43; recessive model: OR 5 1.31, 95% CI 5 1.16-1.48). When stratified by ethnicity, significantly elevated risks were observed among Asian populations (AA versus GG: OR 5 1.31, 95% CI 5 1.01-1.70; dominant model: OR 5 1.14, 95% CI 5 1.00-1.30). This meta-analysis suggests that XPA 24G>A polymorphism is associated with increased lung cancer risk and may be a low-penetrant risk factor in Asian ethnicity for cancer development.

show abstract

Section: Identification and Eligibility Of Relevant Studiesmentioning

confidence: 99%

mentioning

confidence: 99%

Genetic variation of XPA gene and risk of cancer: A systematic review and pooled analysis

Ding

Zhang

et al. 2011

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Certain single nucleotide polymorphisms in the XP gene have been seen with a higher frequency in sporadic gastric carcinomas and have been proposed to be useful markers for identifying high-risk individuals [148].…”

Section: Molecular Geneticsmentioning

confidence: 99%

Familial Gastric Cancers

et al. 2015

View full text Add to dashboard Cite

Although the majority of gastric carcinomas are sporadic, approximately10% show familial aggregation, and a hereditary cause is determined in 1%-3% cases. Of these, hereditary diffuse gastric cancer is the most recognized predisposition syndrome. Although rare, the less commonly known syndromes also confer a markedly increased risk for development of gastric cancer. Identification and characterization of these syndromes require a multidisciplinary effort involving oncologists, surgeons, genetic counselors, biologists, and pathologists.This article reviews the molecular genetics, clinical and pathologic features, surveillance guidelines, and preventive measures of common and less common hereditary gastric cancer predisposition syndromes. The Oncologist 2015; 20:1365-1377Implications for Practice: Although the majority of gastric adenocarcinomas are sporadic with many of those related to chronic Helicobacter pylori infection, approximately 10% of the cases show familial aggregation, and a specific hereditary cause is determined in 1%-3% cases.This review describes the molecular genetics, clinical and pathologic features, surveillance guidelines, and preventive measures of common and less common hereditary gastric cancer predisposition syndromes. Ultimately, a better understanding of the biology of these conditions should allow early identification and intervention as part of a multidisciplinary approach involving oncologists, surgeons, genetic counselors, and pathologists.

show abstract

“…colorectal adenoma [33] ); (6) only the one with a larger sample size was selected if the case-control study was included by more than one articles using the same case serious; and (7) if the case-control study covered more than one cancer type using the same control subjects, we never separate them as several independent studies but combined the cancers of the same category together and consider them as one. In the current study, data for meta-analysis were available from 14 articles, including 4,562 cancer cases and 6,593 controls for Lys939Gln (11 studies from 11 articles) [19][20][21][22][23][24][25][26][27][28][29] , 2,496 cases and 3,653 controls for Ala499Val (6 studies from 6 articles) [19,23,24,26,27,29] , 1,429 cases and 2,724 controls for PAT+/-(7 studies from 7 articles) [19,22,26,27,[30][31][32] , respectively.…”

Section: Identification and Eligibility Of Relevant Studiesmentioning

confidence: 99%

“…The reason why researchers neglected digestive system neoplasm might be due to the limited study numbers relevant to this topic (less than five in the above mentioned metaanalyses). [19][20][21][22][23][24][25][26][27][28][29][30][31][32] . To estimate the overall relationship of the three polymorphisms on digestive system cancer risk, as well as to quantify the potential between-study heterogeneity, a meta-analysis including 14 the most recently published and relevant articles was performed in present study.…”

Section: Introductionmentioning

confidence: 99%

XPC polymorphism increases risk of digestive system cancers: Current evidence from a meta-analysis

Jiang

Zhou

Zhang

et al. 2012

Chin. J. Cancer Res.

View full text Add to dashboard Cite

Objective: Xeroderma pigmentosum complementation group C (XPC) participates in the initial recognition of DNA damage during nucleotide excision repair process in global genomic repair. Our meta-analysis was performed to evaluate the association between three polymorphisms (Lys939Gln, PAT+/-and Ala499Val) of XPC gene and risk of digestive system cancers.Methods: All the relevant case-control studies published to April 2011 were identified through searching PubMed. Digestive system cancer risk with the three polymorphisms was estimated for each study by odds ratio (OR) with its 95% confidence interval (95% CI).

show abstract

Polymorphisms of the DNA Repair Gene XPA and XPC and its Correlation With Gastric Cardiac Adenocarcinoma in a High Incidence Population in North China

Abstract: XPA A23G and XPC exon 8 Val499Ala polymorphisms may be useful markers for identifying individuals at risk of developing GCA in the high incidence region of north China.

Cited by 37 publications

References 24 publications

Genetic variation of XPA gene and risk of cancer: A systematic review and pooled analysis

Genetic variation of XPA gene and risk of cancer: A systematic review and pooled analysis

Familial Gastric Cancers

XPC polymorphism increases risk of digestive system cancers: Current evidence from a meta-analysis

Contact Info

Product

Resources

About