Polymorphisms of Superoxide Dismutase, Glutathione Peroxidase and Catalase Genes in Patients with Post-transplant Diabetes Mellitus

Dutkiewicz, Grażyna; Domański, Leszek; Pawlik, Andrzej; Bińczak-Kuleta, Agnieszka; Safranow, Krzysztof; Ciechanowicz, Andrzej; Dziedziejko, Violetta; Pietrzak-Nowacka, Maria; Ciechanowski, Kazimierz

doi:10.1016/j.arcmed.2010.06.006

Cited by 27 publications

(17 citation statements)

References 29 publications

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“…Moreover, another study demonstrated that V Mn-SOD contributes to the development of diabetic retinopathy in Chinese T2D patients (Ye et al, 2008). However, these findings were not supported by Dutkiewicz et al (2010) who did not observe an association of the V Mn-SOD gene with renal complications in diabetes mellitus. Furthermore, Lee and Choi (2006) have demonstrated that the V16A polymorphism of the Mn-SOD gene is not related to the development of diabetes and the progression of diabetic retinopathy, but is associated with diabetic macular edema in Korean T2D patients.…”

Section: Discussioncontrasting

confidence: 51%

“…Thus, genetic variations in antioxidant enzymes could modulate disease risk (Forsberg et al, 2001). The potential involvement of SOD and CAT polymorphisms in susceptibility risk of developing diabetes and its complications has been reported elsewhere, but not in Tunisian T2D (Dutkiewicz et al, 2010;Kariž et al, 2012). A meta-analysis showed a significant association of the T47C C allele of Mn-SOD with reduced risk of diabetic microvascular complications including diabetic nephropathy, diabetic retinopathy, and diabetic polyneuropathy in dominant, recessive, and codominant models (Tian et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Mn-SOD 47 CC genotype in combination with high tea consumption may prevent complications in Tunisian type-2 diabetes

H¹,

Denden²,

Ghazouani³

et al. 2015

Genet. Mol. Res.

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ABSTRACT.Reactive oxygen species metabolizing enzymes may play an important role in the prevention of type-2 diabetes (T2D) complications. We analyzed the association between Cu/Zn-SOD +35 A/C, Mn-SOD T47C, and CAT -21 A/T gene polymorphisms and complications, in combination with tea consumption in Tunisian T2D. A sample of 366 T2D subjects was enrolled in this study. All participants were asked about tea consumption and frequency. Anthropometric, clinical, and routine biochemical characteristics were obtained from subjects' updated medical records. Malondialdehyde, as an early marker of lipid peroxidation, was measured in plasma samples. Urinary polyphenol derivatives (UPDs), as a marker of polyphenols intake, were assessed by the Folin-Ciocalteu assay. SODs and CAT H. Abaidi et al. 8614©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 8613-8622 (2015) genotypes were determined by conventional restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) methods. From all subjects, the results showed that in high tea consumers (>3 cups/ day), the frequency of the Mn-SOD 47 CC genotype was significantly higher in T2D without complications compared with T2D with complications (P = 0.03; OR = 0.284; 95%CI = 0.086-0.939). However, no significant associations were observed with Cu/Zn-SOD +35 A/C or CAT -21 A/T genes polymorphisms. Additionally, the evaluation of UPDs showed that individuals carrying the Mn-SOD 47 CC genotype and consuming more than three cups of tea per day present significantly higher UPDs (P = 0.038). In conclusion, the Mn-SOD 47 C variant in combination with high tea consumption may provide protection against complications in T2D.

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Section: Discussioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Mn-SOD 47 CC genotype in combination with high tea consumption may prevent complications in Tunisian type-2 diabetes

H¹,

Denden²,

Ghazouani³

et al. 2015

Genet. Mol. Res.

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“…Only GPX1 SNP rs1050450 was associated with increased risk of PTDM 50. The functional polymorphisms in this gene were shown to be associated with increased intima-media thickness of carotid arteries and risk of cardiovascular and peripheral vascular diseases in type 2 diabetic patients 51,52…”

Section: Genetic Polymorphisms and Risk Of Diabetes Mellitusmentioning

confidence: 98%

Genetic factors in pathogenesis of diabetes mellitus after kidney transplantation

Tarnowski¹,

Słuczanowska-Głąbowska²,

Pawlik³

et al. 2017

TCRM

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Posttransplant diabetes mellitus (PTDM) is one of the major metabolic complications after transplantation of solid organs including the kidney. This type of diabetes mellitus affects allograft survival, cardiovascular complications and overall patient survival. The modifiable risk factors that contribute to PTDM include obesity, some viral infections (eg, hepatitis C virus, cytomegalovirus) and especially immunosuppressive drugs including corticosteroids, tacrolimus, cyclosporine and sirolimus. Currently, predisposing genetic factors have been considered important in PTDM development. The commonly evaluated genetic determinants include genes encoding transcription factors, cytokines, chemokines, adipokines, ionic channels, glucose transporters, cytochrome P450 enzymes and other enzymes metabolizing drugs, drug transporters. Unfortunately, the results of studies are inconclusive and differ between populations. There is a need for large genome-wide association study to identify the genetic risk factors associated with PTDM development.

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“…In the last decade, numerous other genetic studies for PTDM have been conducted in renal transplant recipients, and nearly 50 loci have been established as suspected loci (Table 4) [7][8][9][10]13,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. Polymorphisms in AIPOQ, CAPN10, CDKAL1, CDKN2A/B, HHEX, KCN11, KCNQ1, SLC30A8, and TCFL2 are known to be associated with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Association of leptin receptor gene polymorphisms with post-transplant diabetes mellitus: Short report and literature review

Kim¹,

Ihm²,

Lee³

et al. 2017

Trends in Transplant

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Background: Post-transplant diabetes mellitus (PTDM) is a common and important metabolic complication after renal transplantation. Although genetic variants of the leptin (LEP) and leptin receptor (LEPR) gene have been reported to be associated with insulin resistance and diabetes mellitus, few studies have examined these variants in patients with post-transplant diabetes mellitus (PTDM). In this study, we investigated the association between LEP and LEPR polymorphisms and PTDM in renal transplant recipients. We also reviewed the literature on the genetic variants associated with development of PTDM.

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Polymorphisms of Superoxide Dismutase, Glutathione Peroxidase and Catalase Genes in Patients with Post-transplant Diabetes Mellitus

Cited by 27 publications

References 29 publications

Mn-SOD 47 CC genotype in combination with high tea consumption may prevent complications in Tunisian type-2 diabetes

Mn-SOD 47 CC genotype in combination with high tea consumption may prevent complications in Tunisian type-2 diabetes

Genetic factors in pathogenesis of diabetes mellitus after kidney transplantation

Association of leptin receptor gene polymorphisms with post-transplant diabetes mellitus: Short report and literature review

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