Polymorphisms of glutathione-S-transferase M1 and T1 and prostate cancer risk in a Tunisian population

Souiden, Yousra; Mahdouani, Manel; Chaieb, Kamel; Elkamel, R.; Mahdouani, Kacem

doi:10.1016/j.canep.2010.06.002

Cited by 23 publications

(26 citation statements)

References 55 publications

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“…Except GSTA1 polymorphism, some studies have been carried out in cancer association with GSTM1, GSTT1, and GSTP1 polymorphisms in North and Centre Tunisian populations (Chelbi et al, 2007;Lakhdar et al, 2010;Souiden et al, 2010). However, conflicting results were shown for the frequency of GSTT1*0/*0 genotype between the North Tunisian population 29.5% (Chelbi et al, 2007) and the Centre Tunisian population 14.7% (Souiden et al, 2010).…”

Section: Introductionmentioning

confidence: 90%

“…The GSTT1 is involved in the biotransformation of several low molecular weight halogenated toxins such as ethylene oxide, butadiene, which are constituents of tobacco smoke (Guengerich et al, 1995). The GSTM and GSTT deletion polymorphisms are reported to play a crucial role in cancer susceptibility (Chelbi et al, 2007;Hatagima et al, 2008;Mohr et al, 2003;Okcu et al, 2004;Souiden et al, 2010;Stoehlmacher et al, 2002).…”

Section: Introductionmentioning

confidence: 96%

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Polymorphisms of glutathione S-transferases M1, T1, P1 and A1 genes in the Tunisian population: An intra and interethnic comparative approach

Salah

Kallabi

Maatoug

et al. 2012

Gene

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 96%

Polymorphisms of glutathione S-transferases M1, T1, P1 and A1 genes in the Tunisian population: An intra and interethnic comparative approach

Salah

Kallabi

Maatoug

et al. 2012

Gene

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“…Genetic factors were considered important in prostate cancer by several studies (4)(5)(6)(7). Since the 1970s, it has been a matter of debate whether prostate cancer, or at least a subgroup of prostate cancer cases, are associated with infection.…”

Section: Introductionmentioning

confidence: 99%

Herpes simplex virus type 2 or human herpesvirus 8 infection and prostate cancer risk: A meta-analysis

Wang

Shen

2013

Biomedical Reports

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Abstract. Prostate cancer is the second most frequently diagnosed type of cancer and the sixth leading cause of cancer mortality among males worldwide. The aim of this study was to investigate the association between the infection by herpes simplex virus type 2 (HSV-2) or human herpesvirus 8 (HHV-8) and the risk of prostate cancer. A systematic literature search was performed using PubMed, Cochrane Library, Web of Science, Scopus, CNKI and CBM. The association of HSV-2 or HHV-8 infection with the risk of prostate cancer was separately assessed. Estimates of the odds ratio (OR) with 95% confidence interval (CI) were pooled by the fixed-or random-effects model. A total of 11 articles with 2,996 cases and 3,875 controls were included in this meta-analysis. HSV-2 infection was associated with increased prostate cancer risk (OR=1.209; 95% CI, 1.003-1.456). Results of the stratified analysis suggested that such an association existed among participants from North and South America (OR=1.226; 95% CI, 1.000-1.503). No significant correlation was observed in the HHV-8 group (OR=1.106; 95% CI, 0.765-1.598). Further investigations and large-sample studies are required to elucidate the possible mechanism underlying viral carcinogenesis and the association between herpes virus infection and the risk of prostate cancer.

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“…With our search criterion, 87 individual records were found and 16 studies with a total of 11,648 subjects were finally included in this meta-analysis [13,14,15,16,17,27,28,29,30,31,32,33,34,35,36,37]. Table 1 shows the main characteristics of those 16 case-control studies.…”

Section: Resultsmentioning

confidence: 99%

<b><i>GSTT1</i></b> Null Genotype Is Associated with an Increased Risk of Prostate Cancer in Caucasians: A Meta-Analysis

Zhu¹,

Chen²,

Xu³

et al. 2013

Urol Int

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Background: Many studies have investigated the association between glutathione S-transferase T1 (GSTT1) null genotype and the risk of prostate cancer (PCa), but the impact of GSTT1 null genotype on PCa risk in Caucasians is still unclear owing to the inconsistency of such studies. The present study aimed to quantify the strength of association between GSTT1 null genotype and the risk of PCa in Caucasians. Methods: We searched the PubMed, Embase and Web of Science databases for studies assessing the association between GSTT1 null genotype and the risk of PCa in Caucasians. We estimated the summary odds ratio (OR) with the corresponding 95% confidence interval (95% CI) to assess the association. Results: 16 case-control studies with 11,648 subjects were included in this meta-analysis. Meta-analysis of a total of 16 studies showed GSTT1 null genotype was significantly associated with an increased risk of PCa in Caucasians (random-effects OR 1.30, 95% CI 1.10-1.53, p = 0.002). After adjustment for heterogeneity, GSTT1 null genotype was still associated with an increased risk of PCa in Caucasians (fixed-effects OR 1.33, 95% CI 1.17-1.52, p < 0.001). The cumulative meta-analyses of all 16 studies showed a trend of more obvious association as information accumulated by year. Conclusions: Meta-analysis of available data suggests the GSTT1 null genotype is significantly associated with an increased risk of PCa in Caucasians.

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Polymorphisms of glutathione-S-transferase M1 and T1 and prostate cancer risk in a Tunisian population

Cited by 23 publications

References 55 publications

Polymorphisms of glutathione S-transferases M1, T1, P1 and A1 genes in the Tunisian population: An intra and interethnic comparative approach

Polymorphisms of glutathione S-transferases M1, T1, P1 and A1 genes in the Tunisian population: An intra and interethnic comparative approach

Herpes simplex virus type 2 or human herpesvirus 8 infection and prostate cancer risk: A meta-analysis

<b><i>GSTT1</i></b> Null Genotype Is Associated with an Increased Risk of Prostate Cancer in Caucasians: A Meta-Analysis

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