Polymorphisms in one-carbon metabolism pathway genes, urinary arsenic profile, and urothelial carcinoma

Chung, Chi Jung; Pu, Yeong-Shiau; Su, Chien Tien; Chen, Hui-Wen; Huang, Yung Kai; Shiue, Horng Sheng; Hsueh, Yu Mei

doi:10.1007/s10552-010-9589-3

Cited by 43 publications

(34 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The public health implication of these findings is apparent when the BMI extremes in our pooled population are compared. The mean %uMMA in the upper and lower BMI deciles of our population were 13.8% and 9.4%, respectively, similar to the %uMMA difference reported between arsenic-associated urothelial carcinoma cases and controls (12.5% vs. 8.1%, respectively) (Chung et al , 2010). This suggests that the magnitude of the effect of BMI on arsenic methylation efficiency could be relevant to disease risk.…”

Section: Discussionsupporting

confidence: 87%

Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico

Gomez‐Rubio

Roberge

Arendell

et al. 2011

Toxicology and Applied Pharmacology

View full text Add to dashboard Cite

Human arsenic methylation efficiency has been consistently associated with arsenic-induced disease risk. Interindividual variation in arsenic methylation profiles is commonly observed in exposed populations, and great effort has been put into the study of potential determinants of this variability. Among the factors that have been evaluated, body mass index (BMI) has not been consistently associated with arsenic methylation efficiency, however an underrepresentation of the upper BMI distribution was commonly observed in these studies. This study investigated potential factors contributing to variations in the metabolism of arsenic, with specific interest in the effect of BMI where more than half of the population was overweight or obese. We studied 624 adult women exposed to arsenic in drinking water from three independent populations. Multivariate regression models showed that higher BMI, arsenic (+3 oxidation state) methyltransferase (AS3MT) genetic variant 7388, and higher total urinary arsenic, were significantly associated with low percentage of urinary arsenic excreted as monomethylarsonic acid (%uMMA) or high ratio between urinary dimethylarsinic acid and uMMA (uDMA/uMMA); while AS3MT genetic variant M287T was associated with high %uMMA and low uDMA/uMMA. The association between BMI and arsenic methylation efficiency was also evident in each of the three populations when studied separately. This strong association observed between high BMI and low %uMMA and high uDMA/uMMA underscores the importance of BMI as a potential arsenic-associated disease risk factor, and should be carefully considered in future studies associating human arsenic metabolism and toxicity.

show abstract

Section: Discussionsupporting

confidence: 87%

Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico

Gomez‐Rubio

Roberge

Arendell

et al. 2011

Toxicology and Applied Pharmacology

View full text Add to dashboard Cite

show abstract

“…By contrast, Moore et al (19) reported conflicting results, suggesting a lower risk of bladder cancer was observed in individuals carrying either the Ala/Val or Val/Val genotype compared to those carrying the Ala/Ala genotype. The remaining 6 studies reported that there were no statistically significant associations between the Ala222Val polymorphism and bladder cancer risk (6–7,18,20–21,26). For the variant genotypes of Glu429Ala polymorphism, Rouissi et al (6) reported that it was associated with a higher risk of bladder cancer.…”

Section: Discussionmentioning

confidence: 99%

Lack of association between MTHFR Ala222Val and Glu429Ala polymorphisms and bladder cancer risk: A meta-analysis of case-control studies

et al. 2014

View full text Add to dashboard Cite

Bladder cancer is a commom malignancy in the urinary tract that is influenced by genetic and environmental factors. The role of functional polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene with bladder cancer risk remains to be determined. This meta-analysis was performed to derive a more precise estimation of MTHFR Ala222Val and Glu429Ala polymorphisms and bladder cancer risk. Data were collected with the last report up to September 2013. A total of 3,463 cases and 3,927 controls for Ala222Val, and 3,177 cases and 3,502 controls for Glu429Ala were analyzed. The pooled odds ratios (ORs) and 95% confidence interval (CI) were estimated for the association with bladder cancer risk. Overall, no significant associations of Ala222Val and Glu429Ala polymorphisms with bladder cancer risk were found (for Ala222Val: Val/Val vs. Ala/Ala: OR, 1.02; 95% CI: 0.80–1.29; Val/Ala vs. Ala/Ala: OR, 1.02; 95% CI: 0.92–1.12; dominant model: OR, 1.01; 95% CI: 0.87–1.17; recessive model: OR, 1.00; 95% CI: 0.87–1.15; and for Glu429Ala: Ala/Ala vs. Glu/Glu: OR, 1.11; 95% CI: 0.78–1.58; Ala/Glu vs. Glu/Glu: OR, 1.16; 95% CI: 0.95–1.40; dominant model: OR, 1.15; 95% CI: 0.94–1.41; recessive model: OR, 0.96; 95% CI: 0.79–1.15). In stratified analyses by ethnicity, significant associations were observed for Glu429Ala polymorphism in individuals of Middle Eastern descent (Ala/Glu vs. Glu/Glu: OR, 2.11; 95% CI: 1.26–3.53; dominant model: OR, 2.16; 95% CI: 1.16–4.01; recessive model: OR, 1.82; 95% CI: 1.11–3.01). This meta-analysis demonstrated that overall there was no association of MTHFR Ala222Val and Glu429Ala polymorphisms with bladder cancer risk. However, in the stratified analysis by ethnicity the MTHFR Glu429Ala polymorphism was significantly associated with increased bladder cancer risk in individuals of Middle Eastern descent.

show abstract

“…Polymorphisms in a number of genes, including GSTO1 and GSTO2 from glutathione-S-transferase (GST) family which use glutathione as a reducing agent to catalyze pentavalent arsenicals to trivalent forms, GSTP1, GSTZ1, GSTM1, and GSTT1 of GSTs family which involved in the xenobiotic metabolism and play a role in the cellular response mechanism against oxidative stress induced by arsenic, arsenic 3-methyltransferase (AS3MT) which use S-adenosyl-methionine as a methyl donor to produce MMA and DMA, and methylene-tetrahydrofolate reductase (MTHFR) of one-carbon metabolism pathway, have been reported to be associated with the variation in arsenic methylation capacity [33-35] and susceptibility to arsenic-related skin lesions [36-38] and bladder cancer [39-42]. Since the role of gene polymorphisms in arsenic-related hypertension was rarely discussed which still need further research, we could not completely exclude the possible relationship between polymorphisms of these genes and susceptibility to the arsenic-related hypertension.…”

Section: Discussionmentioning

confidence: 99%

Association of urinary monomethylated arsenic concentration and risk of hypertension: a cross-sectional study from arsenic contaminated areas in northwestern China

Shi

et al. 2013

Environ Health

View full text Add to dashboard Cite

BackgroundAlthough some studies mainly from Taiwan, Bangladesh and the United States, have suggested a consistent dose–response increase in the prevalence of hypertension with increasing arsenic exposure, the association between chronic environmental arsenic exposure and the risk of hypertension is still inconclusive. Most of the studies discussed the association from the point of view of arsenic concentration in drinking water or cumulative arsenic exposure (CAE), few involved arsenic speciation into the discussion. In this cross-sectional study, we evaluated the potential association between environmental arsenic exposure through drinking water and the prevalence of hypertension by analyzing not only CAE but also urinary arsenic speciation, and provided data on arsenic exposure and hypertension from mainland of China.MethodsA cross-sectional study was conducted in one of the arsenic contaminated areas in the northwest of China. Among a total of 1005 residents who voluntarily participated in the study, 604 of eligible subjects were confirmed and interviewed door to door. Standing height, body weight, and blood pressure were measured. First void urine was collected and measured for the concentration of urinary arsenic speciation. CAE was calculated in a subpopulation of 360 subjects with detailed water consumption history. The association between urinary arsenic speciation, CAE and the risk of hypertension were analyzed by multiple logistic regressions.ResultsWe found that the levels of urinary arsenic species of inorganic arsenic (iAs), monomethylated arsenic (MMA), dimethylated arsenic (DMA) and total arsenic (tAs) were significantly correlated with systolic or pulse blood pressure. A positive relationship was found between the highest tertile of CAE and hypertension in a dose-dependent manner. Subjects with higher concentration of urinary MMA or lower percentage of DMA tended to be liable to suffer from hypertension. A significant increasing trend of the risk of hypertension with increasing tertiles of MMA concentration was also observed in the logistic regression models both before and after adjustment for confounders.ConclusionsOur findings suggested that arsenic exposure, especially high level of CAE, was positively associated with the prevalence of hypertension, and that higher concentration of urinary MMA might be related to the increased susceptibility to hypertension.

show abstract

Polymorphisms in one-carbon metabolism pathway genes, urinary arsenic profile, and urothelial carcinoma

Abstract: Environmental factors played a more important role in UC carcinogenesis than MTHFR or MS gene polymorphism.

Cited by 43 publications

References 41 publications

Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico

Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico

Lack of association between MTHFR Ala222Val and Glu429Ala polymorphisms and bladder cancer risk: A meta-analysis of case-control studies

Association of urinary monomethylated arsenic concentration and risk of hypertension: a cross-sectional study from arsenic contaminated areas in northwestern China

Contact Info

Product

Resources

About