Polymorphisms for Interleukin 1β Exon 5 and Interleukin 1 Receptor Antagonist in Taiwanese Children With Febrile Convulsions

Abstract

The IL-1Ra allele I is associated with a higher susceptibility to febrile convulsion, which may become a useful marker for predicting the development of febrile convulsions. The IL-1 beta exon 5 gene polymorphisms are not a useful marker for predicting the susceptibility to febrile convulsions.

Interleukin (IL)‐1β, IL‐1 receptor antagonist, IL‐6, IL‐8, IL‐10, and tumor necrosis factor α gene polymorphisms in patients with febrile seizures

“…However, we found that the IL-1 Ra allele I is associated with a higher susceptibility to FSs. This finding is consistent with our previous report (19), and a recent study that demonstrated that the IL-1 Ra intron 2 variable tandem repeat polymorphisms are significantly associated with resistance to FSs (20). However, Haspolat et al (21) found no significant effects of this polymorphism on FSs in Turkish children (73 with FSs and 152 healthy control subjects).…”

Interleukin-1α, Interleukin-1β, and Interleukin-1Ra Polymorphisms in Febrile Seizures

“…Kanemoto et al found overrepresentation of the homozygotes for interleukin-1␤ Ϫ511 allele 2 in patients with temporal lobe epilepsy and hippocampal sclerosis. 6,11 Another study done by Tilgen et al in 99 children with febrile seizure, similar to our findings, also could not show an association between the interleukin-1␤ polymorphism and an increased risk of febrile seizures. But, later, Jin et al reported that they could not find any association between interleukin-1␤ Ϫ511 polymorphism and hippocampal sclerosis.…”

Socioeconomic deprivation independent of ethnicity increases status epilepticus risk

“…When adjusted for socioeconomic deprivation, we found strong independent associations between socioeconomic and Asian ethnicity and the incidence of prolonged febrile seizures. Together these data suggest that genetic factors play a role in the occurrence of CSE and lend support to the hypothesis that there is a genetic predisposition to prolonged febrile seizures (Iwasaki et al., 2002; Tsai et al., 2002; Kanemoto et al., 2003).…”