Polymorphism of lncRNAs in breast cancer: Meta‐analysis shows no association with susceptibility

Abstract

Background: Long non-coding RNAs (lncRNAs) have been the target of considerable attention for their roles in many biological processes. Only a small portion of lncRNAs are functionally characterized, and several approaches have been proposed for investigating the roles of these molecules, including how polymorphisms in lncRNA genomic sites may interfere with their function. Allele frequency variation in single nucleotide polymorphisms (SNPs), for example, has been associated with several diseases, including breast cancer (BC), the most common type of cancer in women. Methods: In the present study, we performed a systematic review of lncRNA SNPs associated with BC and a meta-analysis of some lncRNA SNPs. We found 31 SNPs mapped in 12 lncRNAs associated with BC in 28 case-control studies. Results: Our meta-analysis showed an insignificant difference between the SNPs rs217727, rs3741219, rs2107425 and rs2839698 on H19, as well as rs920778, rs1899663, rs12826786 and rs4759314 on HOTAIR, and BC susceptibility. Conclusions: The present analysis recognized the importance of extensive association studies, including different populations, and further evaluation of potential functional effects caused by lncRNA SNPs. Nevertheless, genetic variants such as SNPs in lncRNAs may play many other essential roles, although this field is still under explored.

Genetic Polymorphism of Long Noncoding RNA H19 in Breast Cancer in Egyptian Females

“…Our data were similar to what conducted by [19] who found that the frequency of T allele was significantly higher in breast cancer patients compared to the controls (P < 0.05).…”

HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer

“…This study also demonstrated that TGAC, CTAT, and TTAT polymorphisms substantially lower the BC risk. In contrast, Mathias et al [ 89 ] predicted no correlation between BC susceptibility and rs4759314, rs920778, rs12826786, and rs1899663 in HOTAIR.…”

The roles of long non-coding RNAs in lung cancer

“…They can affect various aspects of cell activities, such as growth and proliferation, survival, migration and invasion, as well as genomic stability. Thus it is increasingly evidenced that lncRNAs play a key role in tumor growth, lymph node/distant metastasis, and patient survival [22], and the single nucleotide polymorphisms (SNP) of lncRNAs are identified as risk factors and correlated to tumorigenesis and metastasis of cancers [34,35]. More interestingly, some lncRNAs are found to be increased in the plasma of cancer patients, yielding the possibility as diagnostic markers in blood [36,37].…”