Polymorphism of GST and FTO Genes in Risk Prediction of Cataract among a North Indian Population

Chandra, Anu; Raza, Syed Tasleem; Abbas, Shania; Singh, Luxmi; Rizvi, Saliha; Ahmed, Faisal; Eba, Ale; Mahdi, Farzana

doi:10.3109/13816810.2014.907921

Cited by 8 publications

(7 citation statements)

References 49 publications

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“…However, a comparison of the case group in this study with the case and control groups reported by Çelįk et al (2015) with respect to the GSTT1 polymorphisms showed very different results (P < 0.001), suggesting a correlation between the null GSTT1 polymorphism and the development of cataract. Our study was also corroborated by a previous study conducted by Chandra et al (2016) in northern India, who reported that the GSTM1 and GSTT1 polymorphisms were associated with increased risk of cataract development. Further, Saadat et al (2012) reported that the GSTM1-null genotype increased the risk of developing this pathology in an Iranian population.…”

Section: Discussionsupporting

confidence: 80%

Analysis of the prevalence of polymorphisms in the glutathione S transferase gene (GST) in cataract patients from Goiânia

et al. 2016

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ABSTRACT. The aim of this study was to determine the prevalence of polymorphisms in the glutathione S-transferase genes GSTM1 and GSTT1 in patients with lens opacity (cataract). Peripheral blood samples were obtained from male and female patients (N = 23) with cataract. The GSTM1 and GSTT1 polymorphic regions were amplified by polymerase chain reaction, and the amplification products were electrophoresed on a 2% agarose gel. The obtained bands were visualized by staining with ethidium bromide. The results were compared by a chi-square test using the BioEstat software (v.5.0). The frequencies of the GSTM1-and GSTT1-null genotypes were higher than those of the GSTM1-and GSTT1-present genotypes. The frequency of GSTT1-null genotypes was approximately 1.7 times higher than that of GSTM1, which was a statistically significant difference (P = 0.0019). Although a consensus remains to be reached on the correlation between genetic polymorphisms in GSTs and cataract susceptibility, the observations from most scientific studies are similar to those reported in this study. Thus, we conclude that the absence of these genes, particularly GSTT1, is correlated with the development of lens opacity.

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Section: Discussionsupporting

confidence: 80%

Analysis of the prevalence of polymorphisms in the glutathione S transferase gene (GST) in cataract patients from Goiânia

et al. 2016

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“…Flow diagram of studies included in this meta-analysis is provided in Figure 1 . Fifteen studies [ 18 – 32 ] were included in the meta-analysis of the GSTM1 genotype (3165 cases, 2105 controls), and nine studies were included in the meta-analysis of GSTT1 (2374 cases, 1544 controls). For the meta-analysis of GSTM1 , six studies on Asians and nine on Caucasians were included.…”

Section: Resultsmentioning

confidence: 99%

An Updated Meta-Analysis: Risk Conferred by Glutathione S-Transferases (GSTM1andGSTT1) Polymorphisms to Age-Related Cataract

Liao

Liu

et al. 2015

Journal of Ophthalmology

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Purpose. To study the effects of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms on age-related cataract (ARC). Methods. After a systematic literature search, all relevant studies evaluating the association between GSTs polymorphisms and ARC were included. Results. Fifteen studies on GSTM1 and nine studies on GSTT1 were included in this meta-analysis. In the pooled analysis, a significant association between null genotype of GSTT1 and ARC was found (OR = 1.229, 95% CI = 1.057–1.429, and P = 0.007). In subgroup analysis, the association between cortical cataract (CC) and GSTM1 null genotype was statistically significant (OR = 0.713, 95% CI = 0.598–0.850, and P < 0.001). In addition, GSTM1 null genotype was significantly associated with ARC causing risk to individuals working indoors and not individuals working outdoors. The association between GSTT1 null genotype and risk of ARC was statistically significant in Asians (OR = 1.442, 95% CI = 1.137–1.830, and P = 0.003) but not in Caucasians. Conclusions. GSTM1 positive genotype is associated with increased risk of CC and loses the protective role in persons who work outdoors. Considering the ethnic variation, GSTT1 null genotype is found to be associated with increased risk of ARC in Asians but not in Caucasians.

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“…They have found a two-fold risk of developing senile cortical cataracts associated with the GSTM 1-positive phenotype. Similarly Chandra et al [21] also found 1.9 (95% Cl: 1.08-3.32) risk of developing cataract with the GSTM 1-positive phenotype in Indian population. However, GSTT 1-positive phenotype has protective effect (OR: 0.27, 95% CI, 0.09-0.86) was determined in this study.…”

Section: Discussionmentioning

confidence: 97%

“…Several studies have indicated that GST enzymes may play a role in cataract predisposition with different GST phenotypes [16,[20][21][22][23] but no associations were found in another study [24].…”

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confidence: 99%

Glutathione S-Transferase GSTM 1, Null Genotype May Be Associated With Susceptibility to Age-Related Cataract

Çelik¹,

Yıldırım²,

Turan³

et al. 2015

Adv Clin Exp Med

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Background. Age-related cataract (ARC) is the leading cause of visual disability and reversible blindness all over the world. The different expressions of GST isozymes among animals may explain the variations in the cataract formation caused by oxidative stress. Objectives. In this study, we evaluated the distribution of GST gene polymorphisms in ARC patients and the possible associations between the presence of ARC and GST gene polymorphisms. Material and Methods. The epidemiological data was collected by a standard questionnaire and blood samples were obtained from 130 ARC patients and 159 healthy controls. Data about smoking habits of the groups was recorded. Real-time polymerase chain reaction-based methods were used to detect genetic polymorphisms. Results. The GSTM 1 null genotype was found to carry an increased risk for developing ARC (OR: 1.84, 95% CI: 1.13-2.99). The frequency of the GSTT 1 null genotype was not significantly different among the ARC patients and the controls (OR: 1.0, 95% CI: 0.64-1.6). The GSTP 1 Val/Val genotype was also not significantly different among the ARC patients and control groups (OR: 1.06, 95% CI: 0.50-2.23). GSTM 1 null genotype was highly frequent in non-smokers (OR: 3.25, 95% CI: 1.66-6.35) and moderately frequent in smokers (OR: 2.50, 95% CI: 1.28-4.86). Also, carrying the combined genotypes of GSTM 1 null, GSTT 1 and GSTP 1 105-Val allele was seen to have an increased risk of developing ARC (OR: 2.91, 95% CI: 1.31-6.44). Conclusions. This data may provide evidence that GSTM 1 gene polymorphisms may be associated with genetic susceptibility to develop ARC. Larger studies are warranted to verify these findings (Adv Clin Exp Med 2015, 24, 1, 113-119).

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Polymorphism of GST and FTO Genes in Risk Prediction of Cataract among a North Indian Population

Abstract: The present study suggested that GSTM1, GSTT1 and FTO gene polymorphisms are associated with increased risk for cataract in North Indian populations. Due to the limited sample size, the finding on GST and FTO gene polymorphisms need further investigation.

Cited by 8 publications

References 49 publications

Analysis of the prevalence of polymorphisms in the glutathione S transferase gene (GST) in cataract patients from Goiânia

Analysis of the prevalence of polymorphisms in the glutathione S transferase gene (GST) in cataract patients from Goiânia

An Updated Meta-Analysis: Risk Conferred by Glutathione S-Transferases (GSTM1andGSTT1) Polymorphisms to Age-Related Cataract

Glutathione S-Transferase GSTM 1, Null Genotype May Be Associated With Susceptibility to Age-Related Cataract

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