2018
DOI: 10.3389/fmed.2018.00252
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Polymorphic Light Eruption: What's New in Pathogenesis and Management

Abstract: Polymorphic light eruption is the commonest photosensitive disorder, characterized by an intermittent eruption of non-scarring erythematous papules, vesicles or plaques that develop within hours of ultraviolet radiation exposure of patient skin. Together with the lesions, a terrible itch starts and increases with the spreading of the disease, sometimes aggravated by a sort of burning sensation. Clinical picture and symptoms can improve during the rest of the summer with further solar exposures. In the last yea… Show more

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Cited by 37 publications
(27 citation statements)
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“…Previous literatures often emphasized that in either serum or skin lesions, the proportion of CD8 + cell is higher than CD4 + cell, which was used as an important point to differentiate CAD from CTCL 6,25 . However, Morris etc had found that in polymorphic solar eruption, the earlier the MED‐induced eruption was taken, the more CD4 + lymphocyte infiltrated 26,27 . No difference between CD4 + and CD8 + cells in our study might be influenced by the time of the biopsy.…”
Section: Discussioncontrasting
confidence: 52%
See 1 more Smart Citation
“…Previous literatures often emphasized that in either serum or skin lesions, the proportion of CD8 + cell is higher than CD4 + cell, which was used as an important point to differentiate CAD from CTCL 6,25 . However, Morris etc had found that in polymorphic solar eruption, the earlier the MED‐induced eruption was taken, the more CD4 + lymphocyte infiltrated 26,27 . No difference between CD4 + and CD8 + cells in our study might be influenced by the time of the biopsy.…”
Section: Discussioncontrasting
confidence: 52%
“…6,25 However, Morris etc had found that in polymorphic solar eruption, the earlier the MED-induced eruption was taken, the more CD4 + lymphocyte infiltrated. 26,27 No difference between CD4 + and CD8 + cells in our study might be influenced by the time of the biopsy. Therefore, we suppose that there are more CD4 + lymphocytes in the early phase of CAD skin lesion, but dynamic observation is still required.…”
Section: F I G U R E 2 Hematoxylin and Eosin (He) And Immunohistochemical (Ihc) Stain Of Lichenoid Lesion Med Analysis Erupted Lesion Andmentioning
confidence: 58%
“…High-risk groups, like patients with photosensitive disorders or those with strong family history of skin malignancy, should be identified, and sunscreen use is an important prevention. 7 Where sun protection is discussed, 54% (n = 43) "always" advise their patients to use a sunscreen with UVA coverage; 87% of respondents recommend sunscreen with SPF30 and above, which is consistent with the BAD and WHO guidelines. 3,4 Sunscreens can be prescribed for approved indications or bought over-the-counter.…”
Section: Discussionmentioning
confidence: 66%
“…PLE is a relatively common photosensitive condition. It occurs within hours after sun or UV-radiation exposure presenting with small papules, vesicles or plaques on sun exposed areas 72,73. Conversely, LET, though showing a high sensitivity too, occurs more than 48 hrs after sun exposure and is characterised through wider, urticarial lesions/plaques.…”
Section: Relation To Other (Non-le) Diseasesmentioning
confidence: 99%