Polymers for oral and dental tissue engineering

Salehi, Asiyeh; Rad, Maryam Rezai; Nazeman, Pantea; Khojasteh, Arash

doi:10.1016/b978-0-08-100961-1.00003-7

Cited by 18 publications

(13 citation statements)

References 118 publications

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“…Naturally derived polymers have excellent properties in the areas of immunogenic response and biocompatibility. One of the reasons for naturally derived polymers’ excellent biocompatibility properties is the possession of known cell-binding sites [ 97 , 98 ]. These sites allow for the present growth factors to help the regeneration of the desired tissue [ 98 ].…”

Section: Advantages and Disadvantages Of Naturally Derived Polymermentioning

confidence: 99%

Bioactive Polymeric Materials for the Advancement of Regenerative Medicine

Iovene

Zhao

Wang

et al. 2021

JFB

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Biopolymers are widely accepted natural materials in regenerative medicine, and further development of their bioactivities and discoveries on their composition/function relationships could greatly advance the field. However, a concise insight on commonly investigated biopolymers, their current applications and outlook of their modifications for multibioactivity are scarce. This review bridges this gap for professionals and especially freshmen in the field who are also interested in modification methods not yet in commercial use. A series of polymeric materials in research and development uses are presented as well as challenges that limit their efficacy in tissue regeneration are discussed. Finally, their roles in the regeneration of select tissues including the skin, bone, cartilage, and tendon are highlighted along with modifiable biopolymer moieties for different bioactivities.

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Section: Advantages and Disadvantages Of Naturally Derived Polymermentioning

confidence: 99%

Bioactive Polymeric Materials for the Advancement of Regenerative Medicine

Iovene

Zhao

Wang

et al. 2021

JFB

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“…Even though natural polymers can be considered as the first biodegradable biomaterials employed clinically (Nair and Laurencin, 2007), various commercially available synthetic polymers are endowed with mechanical and physicochemical features comparable to those of biological tissues (Gunatillake et al, 2006). Advantages and disadvantages associated with the biomedical use of natural or synthetic polymers are listed in Table 2 (BaoLin and Ma, 2014;Mohamed and Shamaz, 2015;Bhatia, 2016;Salehi-Nik et al, 2017).…”

Section: Polymer Scaffolds For Btementioning

confidence: 99%

“…-Properties dependence on extraction and processing procedures -Inadequate mechanical properties -Expensive productive methods -Susceptibility to cross-contamination -Difficult processing -Low stability (Bhatia, 2016;Salehi-Nik et al, 2017) (Whang et al, 1995). Electrospinning is a technique where high electrostatic forces are used to squeeze a viscoelastic solution into jet, overcoming its internal cohesive forces: upon solvent evaporation, nano/micro sized fibers are formed (Bürck et al, 2018).…”

Section: Polymer Scaffolds For Btementioning

confidence: 99%

“…Cross-linking and other strategies of chemical modification enable the designer to control the lifetime of the implant, with important impact in the applications where scaffolds are supposed to deliver a specific function over a precise period of time before being replaced by newly formed tissue (Lee and Shin, 2007;Lee and Yuk, 2007;Bhatia, 2016;Salehi-Nik et al, 2017). However, this natural feature carries certain limitations.…”

Section: Future Perspective and Conclusionmentioning

confidence: 99%

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Natural Polymeric Scaffolds in Bone Regeneration

Filippi

Born

Chaaban

et al. 2020

Front. Bioeng. Biotechnol.

248

151

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Despite considerable advances in microsurgical techniques over the past decades, bone tissue remains a challenging arena to obtain a satisfying functional and structural restoration after damage. Through the production of substituting materials mimicking the physical and biological properties of the healthy tissue, tissue engineering strategies address an urgent clinical need for therapeutic alternatives to bone autografts. By virtue of their structural versatility, polymers have a predominant role in generating the biodegradable matrices that hold the cells in situ to sustain the growth of new tissue until integration into the transplantation area (i.e., scaffolds). As compared to synthetic ones, polymers of natural origin generally present superior biocompatibility and bioactivity. Their assembly and further engineering give rise to a wide plethora of advanced supporting materials, accounting for systems based on hydrogels or scaffolds with either fibrous or porous architecture. The present review offers an overview of the various types of natural polymers currently adopted in bone tissue engineering, describing their manufacturing techniques and procedures of functionalization with active biomolecules, and listing the advantages and disadvantages in their respective use in order to critically compare their actual applicability potential. Their combination to other classes of materials (such as micro and nanomaterials) and other innovative strategies to reproduce physiological bone microenvironments in a more faithful way are also illustrated. The regeneration outcomes achieved in vitro and in vivo when the scaffolds are enriched with different cell types, as well as the preliminary clinical applications are presented, before the prospects in this research field are finally discussed. The collection of studies herein considered confirms that advances in natural polymer research will be determinant in designing translatable materials for efficient tissue regeneration with forthcoming impact expected in the treatment of bone defects.

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“…Typically, with the use of heat or organic solvent, discrete microspheres sinter together into a cohesive network. Furthermore, gaseous or subcritical CO 2 is used in preparing microsphere sintered scaffolds in the presence of cartilage cells (V. Gupta, Khan, Berkland, Laurencin, & Detamore, 2017; Jeon et al, 2013; Salehi‐Nik, Rezai Rad, Nazeman, & Khojasteh, 2017; Singh, Sandhu, Scurto, Berkland, & Detamore, 2010). Studies involving microsphere sintered titanium alloy (Ti6Al4V) scaffolds incorporated with recombinant human bone morphogenetic protein (rhBMP‐2) enhances bone regeneration (J. Li et al, 2019).…”

Section: Techniques For the Preparation Of Scaffoldsmentioning

confidence: 99%

Fabrication techniques of biomimetic scaffolds in three‐dimensional cell culture: A review

Badekila

Kini

Jaiswal

2020

Journal Cellular Physiology

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In the last four decades, several researchers worldwide have routinely and meticulously exercised cell culture experiments in two-dimensional (2D) platforms. Using traditionally existing 2D models, the therapeutic efficacy of drugs has been inappropriately validated due to the failure in generating the precise therapeutic response. Fortunately, a 3D model addresses the foregoing limitations by recapitulating the in vivo environment. In this context, one has to contemplate the design of an appropriate scaffold for favoring the organization of cell microenvironment. Instituting pertinent model on the platter will pave way for a precise mimicking of in vivo conditions. It is because animal cells in scaffolds oblige spontaneous formation of 3D colonies that molecularly, phenotypically, and histologically resemble the native environment. The 3D culture provides insight into the biochemical aspects of cell-cell communication, plasticity, cell division, cytoskeletal reorganization, signaling mechanisms, differentiation, and cell death. Focusing on these criteria, this paper discusses in detail, the diversification of polymeric scaffolds based on their available resources. The paper also reviews the well-founded and latest techniques of scaffold fabrication, and their applications pertaining to tissue engineering, drug screening, and tumor model development.

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Polymers for oral and dental tissue engineering

Cited by 18 publications

References 118 publications

Bioactive Polymeric Materials for the Advancement of Regenerative Medicine

Bioactive Polymeric Materials for the Advancement of Regenerative Medicine

Natural Polymeric Scaffolds in Bone Regeneration

Fabrication techniques of biomimetic scaffolds in three‐dimensional cell culture: A review

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