Polymeric worm micelles as nano-carriers for drug delivery

Kim, Young-Hoon; Dalhaimer, Paul; Christian, David A.; Discher, Dennis E.

doi:10.1088/0957-4484/16/7/024

Cited by 203 publications

(143 citation statements)

References 26 publications

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“…[ 132 ] Since fl exibility is an important parameter to target tissues, the performance of PEO-PEE and PEO-poly(lactic acid) (PEO-PLA) spherical and worm-like micelles was studied through permeation in agarose gels as a strategy to mimic porous tissues. [ 133 ] For gels with pore sizes of 100 nm, spherical vesicles stuck at the entrance of the gel whereas the more-fl exible wormlike micelles were capable to permeate through the structure. Paclitaxel-loaded PEO-b-PCL elongated micelles can be stored at low temperatures and neutral pH for months, without degradation.…”

Section: Non-spherical Micellesmentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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Particulate systems have been widely used as containers of drugs or cells with the purpose of releasing them in a particularThe search for more effi cient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the fi eld of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non-conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more effi cient cell internalization and traffi cking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical fi eld.

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Section: Non-spherical Micellesmentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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“…[9][10][11][12][13][14][15] These block copolymer micelles can be potentially used in specific biological and medical applications. [16][17][18] To obtain different micelle morphologies of block copolymers in solutions, two sets of parameters need to be taken into account. The first set consists of molecular parameters associated with the block copolymer itself, such as the chemical nature (hydrophobicity or hydrophilicity) of the blocks, the block and overall molecular weights, the miscibility of the blocks, and the block copolymer architectures (linear, star, graft, etc.).…”

Section: Introductionmentioning

confidence: 99%

Self‐assembled, wormlike‐cylinder network of polystyrene‐block‐poly(ethylene oxide) micelles in solution

Bhargava¹,

Zheng²,

Quirk³

et al. 2006

J Polym Sci B Polym Phys

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ABSTRACT:We report the formation of a highly entangled and interconnected, selfassembled, wormlike-cylinder network of polystyrene-block-poly(ethylene oxide) in N, N-dimethylformamide/water. In this system, N,N-dimethylformamide was a common solvent and water was a selective solvent for the poly(ethylene oxide) blocks. The degrees of polymerization of the polystyrene and poly(ethylene oxide) blocks were 962 and 227, respectively. The network was formed at copolymer concentrations higher than 0.4 wt % and consisted of self-assembled, wormlike cylinders that were interconnected by Y-shaped, T-shaped, and multiple junctions. The network morphology was visualized with transmission electron microscopy. Capillary viscometry measurements revealed an order-of-magnitude increase in the inherent viscosity of the colloidal system upon the formation of the network. A similar effort to obtain a wormlike-cylinder network in an N,N-dimethylformamide/acetonitrile system, in which acetonitrile was a selective solvent for the poly(ethylene oxide) blocks, was unsuccessful even at high copolymer concentrations; instead, the wormlike cylinders showed a tendency to align. The viscosity measurements also did not show a substantial increase in the inherent viscosity. Thus, the solvent played a critical role in determining the formation of the self-assembled, wormlike-cylinder network. This formation of the network resulted from an interplay between the end-capping energy, bending energy (curvature), and configurational entropy of the self-assembled, wormlike-cylinder micelles that minimized the free energy.

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“…This results in poration and hydrophobic or hydrophilic drug release from worm-like micelles or vesicles. [14][15][16][17] Even though the experimental settings are usually complex, computer simulations can play an important role in gaining detailed insights into structures and also in offering new design strategies.…”

Section: Introductionmentioning

confidence: 99%

Computer simulation of aqueous block copolymer assemblies: Length scales and methods

Ortiz

Nielsen

Klein

et al. 2006

J Polym Sci B Polym Phys

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Atomistic, coarsegrain, and mesoscopic computer simulation methods applied recently to the study of block copolymer assemblies in solution are reviewed. At the atomic level, particle-based simulations have provided insight into specific interactions such as hydrogen bonding between polymer and water.Coarse-grain models have given a generalized view of the conformations of polymer chains in solvents of different qualities by grouping clusters of atoms into effective interaction sites. Mesoscopic selfconsistent field theory allows for the study of the phase diagram of block copolymers in water using a mean-field continuum description. [1907][1908][1909][1910][1911][1912][1913][1914][1915][1916][1917][1918] 2006 Keywords: all-atom; coarse-grain; DPD; field theory; molecular dynamics Kingston, ON in 1996. In 1998, he received his M.Sc. and Ph.D. degrees from the University of Toronto for his work on the statistical mechanics of mixed quantum-classical systems under the supervision of Raymond E. Kapral. He then moved on to join the group of Michael L. Klein at the University of Pennsylvania as a postdoctoral research associate to work on coarse-grain models of membranes. His current research interests are on the solubilization of carbon nanotubes by cyclic peptides and on a detailed molecular understanding of colloidal stability.

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Polymeric worm micelles as nano-carriers for drug delivery

Cited by 203 publications

References 26 publications

Design Advances in Particulate Systems for Biomedical Applications

Design Advances in Particulate Systems for Biomedical Applications

Self‐assembled, wormlike‐cylinder network of polystyrene‐block‐poly(ethylene oxide) micelles in solution

Computer simulation of aqueous block copolymer assemblies: Length scales and methods

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