Polymeric Scavenger Reagents in Organic Synthesis

Continuous Flow Photochemical and Thermal Multi-Step Synthesis of Bioactive 3-Arylmethylene-2,3-Dihydro-1H-Isoindolin-1-Ones

“…Initial attempts to use excess amounts of amine to neutralize the sulfuric acid were unsatisfactory. Instead, a cartridge filled with an ion exchange resin as an acid scavenger was introduced between the thermal loops [29,30]. After several trials, strongly basic Dowex 1-X8 ion exchange resin was found optimal.…”

Continuous Flow Photochemical and Thermal Multi-Step Synthesis of Bioactive 3-Arylmethylene-2,3-Dihydro-1H-Isoindolin-1-Ones

“…Initial attempts to use excess amounts of amine to neutralize the sulfuric acid were unsatisfactory. Instead, a cartridge filled with an ion exchange resin as an acid scavenger was introduced between the thermal loops [29,30]. After several trials, strongly basic Dowex 1-X8 ion exchange resin was found optimal.…”

Preparation of Polymer-Supported Ligands and Metal Complexes for Use in Catalysis

“…If only a small amount of leaching is observed, then one option would be to use polymer-supported scavengers to remove the small quantities of metal from the product solution. Within the organic chemistry community a range of polymer-supported scavengers have been developed recently for use in purification of reaction mixtures, but attention has been focused primarily on removal of organic substrates. ,, This being said, there have been a number of reports dating from the 1970s forward on preparing and screening scavengers that will sequester metal complexes from solution . Most of these have been related to polymer-supported crown ether or calixerene complexes, a recent example being from Alexandratos and Natesan, who have prepared a range of polymer-supported calix[4]arenes that show quantitative complexation of Fe(II) and Pb(II) from 0.01 M nitric acid.…”

Biocatalysis in Polymer-Supported Synthesis: Enzyme-Labile Linker Groups

“…For instance, one of the emerging trends in compound library synthesis is the use of polymer-fixed reagents. [50][51][52] Many enzymes have been immobilized on polymeric supports and have been applied as such polymer-fixed catalysts in innumerable cases in research and industry. [53] So why should one not use them together with other polymer-fixed reagents in the preparation of compound libraries as well?…”

Continuous Flow Photochemical and Thermal Multi-Step Synthesis of Bioactive 3-Arylmethylene-2,3-Dihydro-1H-Isoindolin-1-Ones

“…Initial attempts to use excess amounts of amine to neutralize the sulfuric acid were unsatisfactory. Instead, a cartridge filled with an ion exchange resin as an acid scavenger was introduced between the thermal loops [29,30]. After several trials, strongly basic Dowex 1-X8 ion exchange resin was found optimal.…”

Preparation of Polymer-Supported Ligands and Metal Complexes for Use in Catalysis

“…If only a small amount of leaching is observed, then one option would be to use polymer-supported scavengers to remove the small quantities of metal from the product solution. Within the organic chemistry community a range of polymer-supported scavengers have been developed recently for use in purification of reaction mixtures, but attention has been focused primarily on removal of organic substrates. ,, This being said, there have been a number of reports dating from the 1970s forward on preparing and screening scavengers that will sequester metal complexes from solution . Most of these have been related to polymer-supported crown ether or calixerene complexes, a recent example being from Alexandratos and Natesan, who have prepared a range of polymer-supported calix[4]arenes that show quantitative complexation of Fe(II) and Pb(II) from 0.01 M nitric acid.…”

Biocatalysis in Polymer-Supported Synthesis: Enzyme-Labile Linker Groups

“…For instance, one of the emerging trends in compound library synthesis is the use of polymer-fixed reagents. [50][51][52] Many enzymes have been immobilized on polymeric supports and have been applied as such polymer-fixed catalysts in innumerable cases in research and industry. [53] So why should one not use them together with other polymer-fixed reagents in the preparation of compound libraries as well?…”

Continuous Flow Photochemical and Thermal Multi-Step Synthesis of Bioactive 3-Arylmethylene-2,3-Dihydro-1H-Isoindolin-1-Ones

“…Initial attempts to use excess amounts of amine to neutralize the sulfuric acid were unsatisfactory. Instead, a cartridge filled with an ion exchange resin as an acid scavenger was introduced between the thermal loops [29,30]. After several trials, strongly basic Dowex 1-X8 ion exchange resin was found optimal.…”

Preparation of Polymer-Supported Ligands and Metal Complexes for Use in Catalysis

“…If only a small amount of leaching is observed, then one option would be to use polymer-supported scavengers to remove the small quantities of metal from the product solution. Within the organic chemistry community a range of polymer-supported scavengers have been developed recently for use in purification of reaction mixtures, but attention has been focused primarily on removal of organic substrates. ,, This being said, there have been a number of reports dating from the 1970s forward on preparing and screening scavengers that will sequester metal complexes from solution . Most of these have been related to polymer-supported crown ether or calixerene complexes, a recent example being from Alexandratos and Natesan, who have prepared a range of polymer-supported calix[4]arenes that show quantitative complexation of Fe(II) and Pb(II) from 0.01 M nitric acid.…”

Biocatalysis in Polymer-Supported Synthesis: Enzyme-Labile Linker Groups

“…For instance, one of the emerging trends in compound library synthesis is the use of polymer-fixed reagents. [50][51][52] Many enzymes have been immobilized on polymeric supports and have been applied as such polymer-fixed catalysts in innumerable cases in research and industry. [53] So why should one not use them together with other polymer-fixed reagents in the preparation of compound libraries as well?…”