Polymeric mixed micelles as nanomedicines: Achievements and perspectives

Cagel, Maximiliano; Tesan, Fiorella Carla; Bernabeu, Ezequiel; Salgueiro, M.; Zubillaga, Marcela; Morettón, Marcela A.; Chiappetta, Diego Andrés

doi:10.1016/j.ejpb.2016.12.019

Cited by 325 publications

(159 citation statements)

References 179 publications

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“…Micelles are generally made up of 50-200 monomers. The parameter which affects the micelle formation was the size of the hydrophobic area of amphiphilic molecule, amphiphile concentration, temperature, and solvent [70]. Polymeric micelle holds the diameter of 10-100 nm.…”

Section: Nanomicelles For the Treatment Of Ramentioning

confidence: 99%

Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights

Janakiraman

Krishnaswami

Rajendran

et al. 2018

Materials Today Communications

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A B S T R A C TRheumatoid arthritis (RA) is the most common complex multifactorial joint related autoimmune inflammatory disease with unknown etiology accomplished with increased cardiovascular risks. RA is characterized by the clinical findings of synovial inflammation, autoantibody production, and cartilage/bone destruction, cardiovascular, pulmonary and skeletal disorders. Pro-inflammatory cytokines such as IL-1, IL-6, IL-8, and IL-10 were responsible for the induction of inflammation in RA patients. Drawbacks such as poor efficacy, higher doses, frequent administration, low responsiveness, and higher cost and serious side effects were associated with the conventional dosage forms for RA treatment. Nanomedicines were recently gaining more interest towards the treatment of RA, and researchers were also focusing towards the development of various anti-inflammatory drug loaded nanoformulations with an aid to both actively/passively targeting the inflamed site to afford an effective treatment regimen for RA. Alterations in the surface area and nanoscale size of the nanoformulations elicit beneficial physical and chemical properties for better pharmacological activities. These drug loaded nanoformulations may enhances the solubility of poorly water soluble drugs, improves the bioavailability, affords targetability and may improve the therapeutic activity. In this regimen, the present review focus towards the novel nanoparticulate formulations (nanoparticles, nanoemulsions, solid lipid nanoparticles, nanomicelles, and nanocapsules) utilized for the treatment of RA. The recent advancements such as siRNA, peptide and targeted based nanoparticulate systems for RA treatment were also discussed. Special emphasis was provided regarding the pathophysiology, prevalence and symptoms towards the development of RA.

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Section: Nanomicelles For the Treatment Of Ramentioning

confidence: 99%

Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights

Janakiraman

Krishnaswami

Rajendran

et al. 2018

Materials Today Communications

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“…Their tissue specificity is first confined to the cells of the reticuloendothelial system which recognizes them as foreign microparticles and transports them to liver and spleen . Among the alternatives to overcome these inconveniences, the inclusion of drugs in polymeric micelles and the synthesis of polymer–drug conjugates by click chemistry are the most attractive options nowadays …”

Section: Introductionmentioning

confidence: 99%

“…On the one hand, polymeric micelles as carriers for hydrophobic drugs are being investigated in many research groups in order to improve the solubility of these drugs due to, among other things, the simplicity in general of micelle formation methods. In addition, block copolymer micelles have diameters between 10 and 200 nm typically; due to this size neither renal filtration nor uptake by the reticuloendothelial system occurs so that the micelles circulate in the blood stream for a long time and therapeutic efficacy is enhanced .…”

Section: Introductionmentioning

confidence: 99%

Different drug incorporation routes in ethylene oxide based copolymers

Carrero

Borreguero

Rodrı́guez

et al. 2020

Polymer International

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Coumarin is successfully incorporated in poly(ethylene oxide)‐poly(propylene oxide) block copolymers functionalized with terminal alkynes, PEO‐b‐PPO‐b‐GPE, by click reactions at atmospheric pressure and in CO2 supercritical conditions (scCO2). The presence of glycidyl propargyl ether (GPE), an alkynyl‐terminated monomer, in the copolymer chain allows the covalent attachment of the coumarin by click chemistry, obtaining polymer–drug conjugates. First, the most suitable synthesis procedure for the above‐mentioned copolymers was established. Then, the click reactions were carried out confirming the coumarin attachment by Fourier transform IR and 1H NMR analyses, achieving good yields in both cases with a coumarin content of about 9.3 wt% and avoiding the use of toxic solvents in the case of scCO2. In addition, thanks to the amphiphilic character of the copolymer due to the presence of hydrophilic (PEO) and hydrophobic (PPO) segments, micelle formation is also possible and was confirmed by dynamic light scattering and high resolution SEM. Finally, coumarin incorporation was achieved by micelle formation using the direct dissolution method in order to compare the polymer–drug system properties. This second route allows a drug entrapment efficiency of 14 wt% to be reached. In both cases, the size of the polymeric micelles obtained is in a suitable range to enable permeability. However, an interesting point is the reduction in the size of the micelles with increase in the GPE percentage and with the covalent attachment of the coumarin to the copolymer, which is supposed to improve their permeability. © 2019 Society of Chemical Industry

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“…Despite significant advantages, due to the large  conjugate systems, porpyrins easily form aggregates, which have a significantly lower ability for localization at cellular level and consequently decrease the therapeutic effect. So, before pharmaceutical formulation, it is necessary the study of the spectral and aggregation properties of these compounds in membrane mimetic media, such as micelles, in order to determine the factors that modulate porphyrin−membrane interactions and that may resolve the aforementioned problems [4][5][6]. The present study included spectral evaluation of some amphiphilic porphyrins in TX-100/water and TX-100/cyclohexane micelles.…”

mentioning

confidence: 99%

<strong>Effect of Interaction with Micellar Media on Spectral Properties of some Amphiphilic Porphyrins</strong>

Boscencu

Socoteanu

Nacea

et al. 2017

Proceedings of 3rd International Electronic Conference on Medicinal Chemistry

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The use of porphyrinic compounds in the field of theranostic nanomedicine, has increased substantially in the recent years due to their special features such as: long wavelength absorption and emission in the spectral region where the biological tissues absorb, a good photodynamic activity, photostability and low in vivo toxicity [1][2][3]. Despite significant advantages, due to the large  conjugate systems, porpyrins easily form aggregates, which have a significantly lower ability for localization at cellular level and consequently decrease the therapeutic effect. So, before pharmaceutical formulation, it is necessary the study of the spectral and aggregation properties of these compounds in membrane mimetic media, such as micelles, in order to determine the factors that modulate porphyrin−membrane interactions and that may resolve the aforementioned problems [4][5][6]. The present study included spectral evaluation of some amphiphilic porphyrins in TX-100/water and TX-100/cyclohexane micelles. The obtained results suggests for tested compounds the localization at the interface between the polyethylene oxide chains and the tertoctyl-phenyl etheric residue of the surfactant molecules. Regarding to spectral behavior of the studied porphyrins, the experimental results confirms fact that incorporation in micelles will facilitate a better delivery to the cellular target without determine significant change in their photophysical profile.

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Polymeric mixed micelles as nanomedicines: Achievements and perspectives

Cited by 325 publications

References 179 publications

Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights

Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights

Different drug incorporation routes in ethylene oxide based copolymers

<strong>Effect of Interaction with Micellar Media on Spectral Properties of some Amphiphilic Porphyrins</strong>

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