Polymeric hydrogels for post-operative adhesion prevention: A review

Shi, Kun; Xue, Bingxin; Liao, Jinfeng; Qu, Ying; Qian, Zhiyong

doi:10.1166/mex.2017.1403

Cited by 26 publications

(13 citation statements)

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“…[ 5 ] Nonetheless, owing to their increased mechanical properties and improved stability, covalent‐based systems are generally preferred for long‐term biomedical applications. [ 10 ] During the last decades, a variety of crosslinking mechanisms, such as radical polymerization, Michael‐type addition, or Schiff base formation, has been developed for in vivo applications. [ 11 ] Yet, so far, the clinical translation of most of these strategies has been slowed down by inherently limiting factors.…”

Section: Introductionmentioning

confidence: 99%

In Situ Forming, Silanized Hyaluronic Acid Hydrogels with Fine Control Over Mechanical Properties and In Vivo Degradation for Tissue Engineering Applications

Flegeau

Toquet²,

Réthoré

et al. 2020

Adv Healthcare Materials

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In situ forming hydrogels that can be injected into tissues in a minimally-invasive fashion are appealing as delivery vehicles for tissue engineering applications. Ideally, these hydrogels should have mechanical properties matching those of the host tissue, and a rate of degradation adapted for neo-tissue formation. Here, the development of in situ forming hyaluronic acid hydrogels based on the pH-triggered condensation of silicon alkoxide precursors into siloxanes is reported. Upon solubilization and pH adjustment, the low-viscosity precursor solutions are easily injectable through fine-gauge needles prior to in situ gelation. Tunable mechanical properties (stiffness from 1 to 40 kPa) and associated tunable degradability (from 4 days to more than 3 weeks in vivo) are obtained by varying the degree of silanization (from 4.3% to 57.7%) and molecular weight (120 and 267 kDa) of the hyaluronic acid component. Following cell encapsulation, high cell viability (> 80%) is obtained for at least 7 days. Finally, the in vivo biocompatibility of silanized hyaluronic acid gels is verified in a subcutaneous mouse model and a relationship between the inflammatory response and the crosslink density is observed. Silanized hyaluronic acid hydrogels constitute a tunable hydrogel platform for material-assisted cell therapies and tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

In Situ Forming, Silanized Hyaluronic Acid Hydrogels with Fine Control Over Mechanical Properties and In Vivo Degradation for Tissue Engineering Applications

Flegeau

Toquet²,

Réthoré

et al. 2020

Adv Healthcare Materials

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“…2 ) [ 2 , 32 , 33 ]. Different biomaterials use various means and technologies to play an important role in cancer prevention [ 34 – 38 ]. To achieve precise antitumor effects, these advanced biomaterials with different functions can be used to deliver immunopharmaceuticals to organs or tissues (such as the mucosa or skin) that are rich in immune cells by different routes of administration (for instance, intranasally [ 39 ], orally [ 40 ], and subcutaneously [ 41 ]).…”

Section: Introductionmentioning

confidence: 99%

Advanced biomaterials for cancer immunotherapy

et al. 2020

Self Cite

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Immunotherapy, as a powerful strategy for cancer treatment, has achieved tremendous efficacy in clinical trials. Despite these advancements, there is much to do in terms of enhancing therapeutic benefits and decreasing the side effects of cancer immunotherapy. Advanced nanobiomaterials, including liposomes, polymers, and silica, play a vital role in the codelivery of drugs and immunomodulators. These nanobiomaterial-based delivery systems could effectively promote antitumor immune responses and simultaneously reduce toxic adverse effects. Furthermore, nanobiomaterials may also combine with each other or with traditional drugs via different mechanisms, thus giving rise to more accurate and efficient tumor treatment. Here, an overview of the latest advancement in these nanobiomaterials used for cancer immunotherapy is given, describing outstanding systems, including lipid-based nanoparticles, polymer-based scaffolds or micelles, inorganic nanosystems, and others.

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“…As a type of anti-adhesion film, anti-adhesion hydrogel films produced by dissolving various biocompatible polymers in a solvent, such as polylactic acid (PLA), polyethylene glycol (PEG), and hyaluronic acid (HA), are being actively developed [ 5 , 6 , 7 ]. Recently, synthetic polymer hydrogels have emerged as promising biomaterials for anti-adhesion films because of their biocompatibility, water absorption capability, biodegradability and better mechanical properties than natural polymer hydrogels [ 8 ]. In addition, the cross-linking method has been fundamentally applied to develop anti-adhesion films because it can improve the mechanical properties of anti-adhesion films to prevent their quick dissolution in the body [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Terahertz Spectral Properties of PEO-Based Anti-Adhesion Films Cross-Linked by Electron Beam Irradiation

Bark

Maeng

Kim³

et al. 2022

Polymers

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We investigated the spectral property changes in anti-adhesion films, which were cross-linked and surface-modified through electron beam irradiation, using terahertz time-domain spectroscopy (THz-TDS). Polyethylene oxide (PEO), which is a biocompatible and biodegradable polymer, was the main component of these anti-adhesion films being manufactured for testing. The terahertz characteristics of the films were affected by the porosity generated during the freeze-drying and compression processes of sample preparation, and this was confirmed using optical coherence tomography (OCT) imaging. An anti-adhesion polymer film made without porosity was measured by using the THz-TDS method, and it was confirmed that the refractive index and absorption coefficient were dependent on the crosslinking state. To our knowledge, this is the first experiment on the feasibility of monitoring cross-linking states using terahertz waves. The THz-TDS method has potential as a useful nondestructive technique for polymer inspection and analysis.

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Polymeric hydrogels for post-operative adhesion prevention: A review

Cited by 26 publications

References 0 publications

In Situ Forming, Silanized Hyaluronic Acid Hydrogels with Fine Control Over Mechanical Properties and In Vivo Degradation for Tissue Engineering Applications

In Situ Forming, Silanized Hyaluronic Acid Hydrogels with Fine Control Over Mechanical Properties and In Vivo Degradation for Tissue Engineering Applications

Advanced biomaterials for cancer immunotherapy

Terahertz Spectral Properties of PEO-Based Anti-Adhesion Films Cross-Linked by Electron Beam Irradiation

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