Polymeric Drug Delivery Approaches for Colon Targeting: A Review

Kaur, Apninder; Kaur, Amarjeet; Kaur, Vishav Prabhjot; Kaur, Manpreet; Murthy, R. S. R.

doi:10.2174/22103031113036660017

Cited by 22 publications

(20 citation statements)

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“…The calibration curve was prepared with Caffeic Acid (CA) as a standard [5]. Nevertheless, the 0.2 ml of sample extract was mixed with 0.2 ml FCR.…”

Section: Total Phenolic Content (Tpc) Sssaymentioning

confidence: 99%

Effect of Differences Methanol Concentration and Extraction Time on the Antioxidant Capacity, Phenolics Content and Bioactive Constituents of Orthosiphon Stamineus Extracts

et al. 2016

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Bioactive compounds of Orthosiphon stamineus have been known to have the beneficial effects on health. Efficient extraction of these beneficial compounds is very important. The study was conducted to determine the efficiency of methanol as an extraction solvent for bioactive compound extraction of O. stamineus raw materials. Leaf sample was extracted in 25, 50 and 100% methanol and distilled water for 2, 4 and 8 hours at 40 0 C. The free radical scavenging activity (FRSA) method was used to determine antioxidant capacity and Follin-Ciocalteu method was used to determine samples total phenolic compounds. The quantification of bioactive constituents by using the high performance liquid chromatography (HPLC) and the standard markers was used for this analysis such as rosmarinic acid (RA), sinensetin (SEN) and 3-hydroxy-5,6,7,4-tetramethoxyflavone (TMF). The current research shows that the yield of RA concentration was high in 50% methanol extracts at 2, 4 and 8 h of extraction. For the FRSA result showed that methanol at 50% and 100% was the most effective concentration levels inhibition between 45-55% at 8 hours' time extraction. For the total phenolic compound, the 50% methanol concentration in O. stamineus leaf had the highest value compared with 0%, 25% and 100% methanol concentration. But, it was observed that time extraction did not influence the TPC values for different concentrations of methanolic extracts. These indicated that time extraction had affected the total capacities of antioxidant and 50% methanolic extracts was the best concentration for indicated the TPC in the O. Storminess leaf.

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“…The calibration curve was prepared with Caffeic Acid (CA) as a standard [5]. Nevertheless, the 0.2 ml of sample extract was mixed with 0.2 ml FCR.…”

Section: Total Phenolic Content (Tpc) Sssaymentioning

confidence: 99%

Effect of Differences Methanol Concentration and Extraction Time on the Antioxidant Capacity, Phenolics Content and Bioactive Constituents of Orthosiphon Stamineus Extracts

et al. 2016

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“…While HRPF does not offer the structural resolution of X-ray crystallography or multidimensional NMR spectroscopy, it has the noted advantage of using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) as its measurement technique, offering greater flexibility in sample types and solution conditions that can be probed. 1 The underlying principle of HRPF is that the rate of oxidation of a given amino acid is based on two factors: the inherent reactivity of the amino acid (which depends on the structure of the side chain 2 and the sequence context of the amino acid 3,4 ) and the accessibility of the side chain to the hydroxyl radical diffusing in solution 3,[5][6][7] . Samples are exposed to a concentration of hydroxyl radicals generated by any of a variety of means [8][9][10][11][12][13][14][15][16][17] .…”

Section: Introductionmentioning

confidence: 99%

Real Time Normalization of Fast Photochemical Oxidation of Proteins Experiments by Inline Adenine Radical Dosimetry

Sharp

Misra

Persoff³

et al. 2018

Anal. Chem.

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Hydroxyl radical protein footprinting (HRPF) is a powerful method for measuring protein topography, allowing researchers to monitor events that alter the solvent accessible surface of a protein (e.g. ligand binding, aggregation, conformational changes, etc.) by measuring changes in the apparent rate of reaction of portions of the protein to hydroxyl radicals diffusing in solution. Fast Photochemical Oxidation of Proteins (FPOP) offers an ultra-fast benchtop method for radical generation for HRPF, photolyzing hydrogen peroxide using a UV laser to generate high concentrations of hydroxyl radicals that are consumed on roughly a microsecond timescale. The broad reactivity of hydroxyl radicals means that almost anything added to the solution (e.g. ligands, buffers, excipients, etc.) will scavenge hydroxyl radicals, altering their half-life and changing the effective radical concentration experienced by the protein. Similarly, minute changes in peroxide concentration, laser fluence, and buffer composition can alter the effective radical concentration, making reproduction of data challenging. Here, we present a simple method for radical dosimetry that can be carried out as part of the FPOP workflow, allowing for measurement of effective radical concentration in real time. Additionally, by modulating the amount of radical generated, we demonstrate that effective hydroxyl radical yields in FPOP HRPF experiments carried out in buffers with widely differing levels of hydroxyl radical scavenging capacity can be compensated on the fly, yielding statistically indistinguishable results for the same conformer. This method represents a major step in transforming FPOP into a robust and reproducible technology capable of probing protein structure in a wide variety of contexts.

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“…In many cases, the upper digestive tract can cause enzymatic degradation or other chemical damage to the bioactive agent (proteins, peptides, etc. ), thus reducing their bioavailability [ 108 ].…”

Section: Bioavailability Improvementsmentioning

confidence: 99%

Bioavailability Improvement Strategies for Icariin and Its Derivates: A Review

Szabó

Rácz

Dulf

2022

IJMS

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In recent years, there has been considerable interest in icariin (ICA) and its derivates, icariside II (ICS) and icaritin (ICT), due to their wide range of potential applications in preventing cancer, cardiovascular disease, osteoporosis, delaying the effects of Alzheimer’s disease, treating erectile dysfunction, etc. However, their poor water solubility and membrane permeability, resulting in low bioavailability, dampens their potential beneficial effects. In this regard, several strategies have been developed, such as pharmaceutical technologies, structural transformations, and absorption enhancers. All these strategies manage to improve the bioavailability of the above-mentioned flavonoids, thus increasing their concentration in the desired places. This paper focuses on gathering the latest knowledge on strategies to improve bioavailability for enhancing the efficacy of icariin, icariside II, and icaritin. We conclude that there is an opportunity for many further improvements in this field. To the best of our knowledge, no such review articles scoping the bioavailability improvement of icariin and its derivates have been published to date. Therefore, this paper can be a good starting point for all those who want to deepen their understanding of the field.

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Polymeric Drug Delivery Approaches for Colon Targeting: A Review

Cited by 22 publications

References 0 publications

Effect of Differences Methanol Concentration and Extraction Time on the Antioxidant Capacity, Phenolics Content and Bioactive Constituents of Orthosiphon Stamineus Extracts

Effect of Differences Methanol Concentration and Extraction Time on the Antioxidant Capacity, Phenolics Content and Bioactive Constituents of Orthosiphon Stamineus Extracts

Real Time Normalization of Fast Photochemical Oxidation of Proteins Experiments by Inline Adenine Radical Dosimetry

Bioavailability Improvement Strategies for Icariin and Its Derivates: A Review

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