2006
DOI: 10.1111/j.1365-3156.2006.01727.x
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: SummaryThe aim of this study was to compare the sensitivity and specificity of polymerase chain reaction (PCR) using two primer pairs and combined with blood culture, immunoglobulin M enzyme-linked immunosorbent assay (IgM ELISA), microscopic agglutination test (MAT) and slide agglutination test (SAT) in the diagnosis of human leptospirosis. We analysed 124 serum samples: 60 from patients with confirmed leptospirosis, 20 from patients with other diseases and 44 from healthy individuals. Analysing the first ser… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

2
29
0
2

Year Published

2007
2007
2020
2020

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 41 publications
(33 citation statements)
references
References 41 publications
2
29
0
2
Order By: Relevance
“…Two studies showed unclear risk of bias in the reference standard 22,44 and two studies showed unclear risk of bias in the flow timing 39,45 . Two studies have indicated high risk of bias in the patient selection in the applicability criteria 50,51 , and two studies demonstrated a high risk of bias in evaluating the index test 48,65 . In the other studies, there were some unclear applicability criteria in the index test and reference standard 19,21,[23][24][25][26]29,30,32,34,35,38,40,42,43,46,47,49,53,54,57,64,[67][68][69] .…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Two studies showed unclear risk of bias in the reference standard 22,44 and two studies showed unclear risk of bias in the flow timing 39,45 . Two studies have indicated high risk of bias in the patient selection in the applicability criteria 50,51 , and two studies demonstrated a high risk of bias in evaluating the index test 48,65 . In the other studies, there were some unclear applicability criteria in the index test and reference standard 19,21,[23][24][25][26]29,30,32,34,35,38,40,42,43,46,47,49,53,54,57,64,[67][68][69] .…”
Section: Resultsmentioning
confidence: 99%
“…Statistical analyses were performed on both the acute and unspecific phase and only the acute phase. Analysis with excluding particular studies with high risk of bias 48,65 in relation to the index test were conducted, and because there was no significant change they were maintained the meta-analysis.…”
Section: Resultsmentioning
confidence: 99%
“…It has been shown that specific antibodies are detectable in patients who have been free of active disease for long periods [33].…”
Section: Enzyme-linked Immunosorbent Assay (Elisa)mentioning
confidence: 99%
“…It has been demonstrated that both conventional and real-time PCR are useful for early diagnosis during which antibody production has not begun [5]. However, PCR was recommended to be used in combination with serological tests; this improves the sensitivity of the diagnosis of leptospirosis in the first phase of the disease [33].…”
Section: Polymerase Chain Reaction (Pcr)mentioning
confidence: 99%
See 1 more Smart Citation