Polymerase Chain Reaction Evaluation of Infectious Multifocal Serpiginoid Choroiditis

Real-time and nested polymerase chain reaction in the diagnosis of multifocal serpiginoid choroiditis caused by Mycobacterium tuberculosis - a case report

“…A study of MSC patients with polymerase chain reaction (PCR) by Mohan et al [ 5 ] concluded that Mycobacterium tuberculosis (MTb) (53.8 %) was the most common and important etiologic agent for MSC in TB endemic areas. One of the drawbacks of their study was that DNA copy numbers were not assessed by real-time PCR (RT-PCR).…”

Real-time and nested polymerase chain reaction in the diagnosis of multifocal serpiginoid choroiditis caused by Mycobacterium tuberculosis - a case report

“…A study of MSC patients with polymerase chain reaction (PCR) by Mohan et al [ 5 ] concluded that Mycobacterium tuberculosis (MTb) (53.8 %) was the most common and important etiologic agent for MSC in TB endemic areas. One of the drawbacks of their study was that DNA copy numbers were not assessed by real-time PCR (RT-PCR).…”

Eye on cytomegalovirus: Unveiling the ophthalmic impact of cytomegalovirus

“…Its utility extends to detecting less common viral causes, such as HHV-7, identified as the cause of herpetic anterior uveitis in a rare case[ 76 ]. Additionally, PCR identifies CMV as a co-infecting pathogen in multifocal serpiginoid choroiditis, guiding the use of specific antiviral therapies like valganciclovir[ 77 ]. While PCR can detect viral DNA, such as CMV, in pterygium tissue, its presence may not always be significant enough to prove a causal role in the disease[ 78 ].…”

The diagnostic value of polymerase chain reaction for ocular tuberculosis diagnosis in relation to antitubercular therapy response: a meta-analysis

“…Moreover, possible coexistence with viral infection might be encountered, and inflammation subsided after antiviral therapy . (Mohan et al, 2014;Sudheer et al, 2018). Thus, the presence of MTb could not directly attribute to the clinical manifestation as an inflammatory load of aqueous/vitreous samples increase the probability of so-called "bystander" MTb DNA, especially in an endemic setting (Barik et al, 2018).…”

Real-time and nested polymerase chain reaction in the diagnosis of multifocal serpiginoid choroiditis caused by Mycobacterium tuberculosis - a case report

“…A study of MSC patients with polymerase chain reaction (PCR) by Mohan et al [ 5 ] concluded that Mycobacterium tuberculosis (MTb) (53.8 %) was the most common and important etiologic agent for MSC in TB endemic areas. One of the drawbacks of their study was that DNA copy numbers were not assessed by real-time PCR (RT-PCR).…”

Eye on cytomegalovirus: Unveiling the ophthalmic impact of cytomegalovirus

“…Its utility extends to detecting less common viral causes, such as HHV-7, identified as the cause of herpetic anterior uveitis in a rare case[ 76 ]. Additionally, PCR identifies CMV as a co-infecting pathogen in multifocal serpiginoid choroiditis, guiding the use of specific antiviral therapies like valganciclovir[ 77 ]. While PCR can detect viral DNA, such as CMV, in pterygium tissue, its presence may not always be significant enough to prove a causal role in the disease[ 78 ].…”

The diagnostic value of polymerase chain reaction for ocular tuberculosis diagnosis in relation to antitubercular therapy response: a meta-analysis

“…Moreover, possible coexistence with viral infection might be encountered, and inflammation subsided after antiviral therapy . (Mohan et al, 2014;Sudheer et al, 2018). Thus, the presence of MTb could not directly attribute to the clinical manifestation as an inflammatory load of aqueous/vitreous samples increase the probability of so-called "bystander" MTb DNA, especially in an endemic setting (Barik et al, 2018).…”

Real-time and nested polymerase chain reaction in the diagnosis of multifocal serpiginoid choroiditis caused by Mycobacterium tuberculosis - a case report

“…A study of MSC patients with polymerase chain reaction (PCR) by Mohan et al [ 5 ] concluded that Mycobacterium tuberculosis (MTb) (53.8 %) was the most common and important etiologic agent for MSC in TB endemic areas. One of the drawbacks of their study was that DNA copy numbers were not assessed by real-time PCR (RT-PCR).…”

Eye on cytomegalovirus: Unveiling the ophthalmic impact of cytomegalovirus

“…Its utility extends to detecting less common viral causes, such as HHV-7, identified as the cause of herpetic anterior uveitis in a rare case[ 76 ]. Additionally, PCR identifies CMV as a co-infecting pathogen in multifocal serpiginoid choroiditis, guiding the use of specific antiviral therapies like valganciclovir[ 77 ]. While PCR can detect viral DNA, such as CMV, in pterygium tissue, its presence may not always be significant enough to prove a causal role in the disease[ 78 ].…”

The diagnostic value of polymerase chain reaction for ocular tuberculosis diagnosis in relation to antitubercular therapy response: a meta-analysis

“…Moreover, possible coexistence with viral infection might be encountered, and inflammation subsided after antiviral therapy . (Mohan et al, 2014;Sudheer et al, 2018). Thus, the presence of MTb could not directly attribute to the clinical manifestation as an inflammatory load of aqueous/vitreous samples increase the probability of so-called "bystander" MTb DNA, especially in an endemic setting (Barik et al, 2018).…”