Polymer-coated BiOCl nanosheets for safe and regioselective gastrointestinal X-ray imaging

Zelepukin, Ivan V.; Ivanov, Ilya N.; Mirkasymov, Aziz B.; Шевченко, К. Г.; Popov, Anton A.; Prasad, Paras N.; Kabashin, Andrei V.; Deyev, Sergey M.

doi:10.1016/j.jconrel.2022.07.007

Cited by 14 publications

(6 citation statements)

References 52 publications

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“…Bi‐based compounds have a successful track of in vivo application, and BOC is a semiconductor material with excellent biocompatibility. [ 21 ] The internal layered crystal structure of BOC is beneficial to the migration of carriers under light excitation. [ 22 ] Conductive PPy possesses excellent electrochemical and photothermal properties, great light absorption capacity, and excellent biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Light‐Programmable Nanocomposite Hydrogel for State‐Switchable Wound Healing Promotion and Bacterial Infection Elimination

Zhang

Xie

Xing

et al. 2022

Adv Healthcare Materials

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Developing an ideal wound dressing that not only accelerates wound healing but also eliminates potential bacterial infections remains a difficult balancing act. This work reports the design of a light-programmable sodium alginate nanocomposite hydrogel loaded with BiOCl/polypyrrole (BOC/PPy) nanosheets for state-switchable wound healing promotion and bacterial infection elimination remotely. The nanocomposite hydrogel possesses programmable photoelectric or photothermal conversion due to the expanded light absorption range, optimized electron transmission interface, promoted photo-generated charge separation, and transfer of the BOC/PPy nanosheets. Under white light irradiation state, the nanocomposite hydrogel induces human umbilical vein endothelial cells migration and angiogenesis, and accelerates the healing efficiency of mouse skin in vivo. Under near-infrared light irradiation state, the nanocomposite hydrogel presents superior antibacterial capability in vitro, and reaches an antibacterial rate of 99.1% for Staphylococcus aureus infected skin wound in vivo. This light-programmable nanocomposite hydrogel provides an on-demand resolution of biological state-switching to balance wound healing and elimination of bacterial infection.

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Section: Introductionmentioning

confidence: 99%

Light‐Programmable Nanocomposite Hydrogel for State‐Switchable Wound Healing Promotion and Bacterial Infection Elimination

Zhang

Xie

Xing

et al. 2022

Adv Healthcare Materials

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“…Bismuth oxychloride proved to be a very good candidate for fulfilling all these demands. Very good biocompatibility and negligible in vivo toxicity are discussed in [ 41 , 42 ]. Further, BiOCl is a water-insensitive material that exhibits extremely low toxicity as a result of its almost complete insolubility in aqueous solutions such as biological fluids [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Modification of Polyvinyl Chloride Composites for Radiographic Detection of Polyvinyl Chloride Retained Surgical Items

et al. 2023

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The ever-present risk of surgical items being retained represents a real medical peril for the patient and potential liability issues for medical staff. Radiofrequency scanning technology is a very good means to substantially reduce such accidents. Radiolucent medical-grade polyvinyl chloride (PVC) used for the production of medical items is filled with radiopaque agents to enable X-ray visibility. The present study proves the suitability of bismuth oxychloride (BiOCl) and documents its advantages over the classical radiopaque agent barium sulfate (BaSO4). An addition of BiOCl exhibits excellent chemical and physical stability (no leaching, thermo-mechanical properties) and good dispersibility within the PVC matrix. As documented, using half the quantity of BiOCl compared to BaSO4 will provide a very good result. The conclusions are based on the methods of rotational rheometry, scanning electron microscopy, dynamic mechanical analysis, atomic absorption spectroscopy, and the verification of zero leaching of BiOCl out of a PVC matrix. X-ray images of the studied materials are presented, and an optimal concentration of BiOCl is evaluated.

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“…116 Nanomaterials are also prone to biodegradation, bioavailability, and toxicity, raising questions about their long-term use. To circumvent these restrictions, different biomolecules, 117 polymers, 118 and inorganic or metal layers 119 are applied on the surface to alter the surface properties of the 2D sheet. In addition to altering the reactivity and solubility, coatings on 2D sheets can impact cell-material interactions and increase biocompatibility.…”

Section: Acs Biomaterialsmentioning

confidence: 99%

Potential Application Prospects of Biomolecule-Modified Two-Dimensional Chiral Nanomaterials in Biomedicine

Zhao,

Chen,

Cheng

et al. 2024

ACS Biomater. Sci. Eng.

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Chirality, one of the most fundamental properties of natural molecules, plays a significant role in biochemical reactions. Nanomaterials with chiral characteristics have superior properties, such as catalytic properties, optoelectronic properties, and photothermal properties, which have significant potential for specific applications in nanomedicine. Biomolecular modifications such as nucleic acids, peptides, proteins, and polysaccharides are sources of chirality for nanomaterials with great potential for application in addition to intrinsic chirality, artificial macromolecules, and metals. Two-dimensional (2D) nanomaterials, as opposed to other dimensions, due to proper surface area, extensive modification sites, drug loading potential, and simplicity of preparation, are prepared and utilized in diagnostic applications, drug delivery research, and tumor therapy. Current advanced studies on 2D chiral nanomaterials for biomedicine are focused on novel chiral development, structural control, and materials sustainability applications. However, despite the advances in biomedical research, chiral 2D nanomaterials still confront challenges such as the difficulty of synthesis, quality control, batch preparation, chiral stability, and chiral recognition and selectivity. This review aims to provide a comprehensive overview of the origins, synthesis, applications, and challenges of 2D chiral nanomaterials with biomolecules as cargo and chiral modifications and highlight their potential roles in biomedicine.

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Polymer-coated BiOCl nanosheets for safe and regioselective gastrointestinal X-ray imaging

Cited by 14 publications

References 52 publications

Light‐Programmable Nanocomposite Hydrogel for State‐Switchable Wound Healing Promotion and Bacterial Infection Elimination

Light‐Programmable Nanocomposite Hydrogel for State‐Switchable Wound Healing Promotion and Bacterial Infection Elimination

Modification of Polyvinyl Chloride Composites for Radiographic Detection of Polyvinyl Chloride Retained Surgical Items

Potential Application Prospects of Biomolecule-Modified Two-Dimensional Chiral Nanomaterials in Biomedicine

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