J. Neurosci. Res. volume 86, issue 16, P3622-3634 2008 DOI: 10.1002/jnr.21805 View full text
Xiaoqing Cai, Haiqun Jia, Zhongbo Liu, Bei Hou, Cheng Luo, Zhihui Feng, Wenxin Li, Jiankang Liu

Abstract: To find effective agents for Parkinson's disease (PD) prevention and therapy, we examined the protective effects of the polyhydroxylated fullerene derivative C(60)(OH)(24) in a 1-methyl-4-phenylpyridinium (MPP(+)) -induced acute cellular PD model in human neuroblastoma cells and the free radical scavenging effects in this model with an electron spin resonance (ESR) spectrometer. Pretreatment with C(60)(OH)(24) at concentrations greater than 20 microM showed significant protective effects on MPP(+) -induced los…

expand abstract