Polyhydroxyalkanoates – what are the uses? Current challenges and perspectives

Masood, Farha; Yasin, Tariq; Hameed, Abdul

doi:10.3109/07388551.2014.913548

Cited by 61 publications

(22 citation statements)

References 143 publications

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“…Polyhydroxyalkanoates (PHAs) have drawn significant attention due to their physico-chemical properties, which is quite similar to that of plastics and the possibility of producing them from biological materials. The demand of PHA is increasing rapidly and is expected to grow to around 34,000 MT by 2018 [1]. At present, the large scale production of these polymers is limited by expensive feeds and costly recovery processes [2].…”

Section: Introductionmentioning

confidence: 99%

Bioconversion of crude glycerol to polyhydroxyalkanoate by Bacillus thuringiensis under non-limiting nitrogen conditions

Kumar

Ray

Patel

et al. 2015

International Journal of Biological Macromolecules

112

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Section: Introductionmentioning

confidence: 99%

Bioconversion of crude glycerol to polyhydroxyalkanoate by Bacillus thuringiensis under non-limiting nitrogen conditions

Kumar

Ray

Patel

et al. 2015

International Journal of Biological Macromolecules

112

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“…PHB, poly(3hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), poly(3hydroxybutyrate-co-4-hydroxybutyrate) (P3HB4HB), poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHB-HHx), and poly(3-hydroxybutyrate-co-3-hydroxyvalerateco-3-hydroxyhexanoate) (PHBVHHx) are biomaterials that stimulate cell proliferation and tissue regeneration without inducing tumor growth. Experimental studies on rats, dogs and sheep have shown that both PHB and PHBV can act as a scaffolding to regenerating cells of the gastrointestinal tract and blood vessels (Masood et al 2014). For the treatment of nervous system disorders, PHBVHHx appears to be the best of PHAs.…”

Section: Applications Of Polyhydroxyalkanoatesmentioning

confidence: 99%

“…300 species) (Sabbagh and Muhamad 2017;Kosseva and Rusbandi 2018). Production of PHAs in microbial cells is intensified under specific conditions such as the lack of nitrogen, phosphorus, sulfur, potassium, zinc, iron, magnesium or oxygen (Masood et al 2014). PHAs are round shape granules with a diameter of 0.1-0.2 µm which are accumulated in the cytoplasm.…”

Section: Introductionmentioning

confidence: 99%

Transgenic plants as a source of polyhydroxyalkanoates

et al. 2018

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Polyhydroxyalkanoates (PHAs) make a large class of biodegradable biopolymers that are naturally synthesized by numerous microorganisms. These biopolymers could be an alternative to commonly used plastics based on petroleum. Production of PHAs in bioreactors using microorganisms is not widely applied due to its unprofitability. Using transgenic plants for this purpose may be cheaper and more environmental friendly because the biosynthesis of PHAs in plants is based only on water, mineral salts, CO 2 and light. Additionally, plants are not capable of degrading PHAs as bacteria do, and extraction of PHAs from plant tissues is not always necessary. The main objective of this work is a review of possibilities of PHA biosynthesis in transgenic plants and presentation of general information on properties and potential application possibilities of these biopolymers. The possibility of syntheses and accumulation of PHA in several transgenic plants has been studied for some years. Many experiments were performed on model plant Arabidopsis thaliana, however, the research has also revealed a great potential of transgenic crop plants such as camelina (Camelina sativa), tobacco (Nicotiana tabacum) or sugarcane (Saccharum officinarum) as a good sources of PHAs. The highest level of PHAs accumulation in plants was achieved in transgenic A. thaliana (up to 40% of the dry weight of the leaf), and among crop plants in C. sativa (up to 20% of the dry weight of the seed). Increasing knowledge on PHAs permits expansion of the possibilities of these biopolymers use even at a low level of their accumulation in plant tissues.

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“…So far, eight pathways of PHA biosynthesis have been found out; among which three main pathways were explained in figure 5. [47,48]. Among the microbes, C. necator (involves 3 main enzymes βketothiolase, NADPH-dependent acetoacetyl-CoA reductase and PHA synthase) was investigated to the maximum extent.…”

Section: Types Of Phamentioning

confidence: 99%

Bioplastic Polyhydroxyalkanoate (PHA): Recent Advances in Modification and Medical Applications

Mukheem¹,

Hossain²,

Shahabuddin³

et al. 2018

Preprint

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A wide variety of bacteria are found to be the tiny factories in the production of polyhydroxyalkanoate (PHA) biopolymer. PHA is the polyesters of 3-hydroxyalkanoic acids which occur in bacteria when the bacteria is subjected to nutrient limitation and simultaneously fed with an excess amount of carbon. This unfavorable condition forces the bacteria to store carbon in the form of resorbable cellular inclusions called PHA. Biosynthesized PHA has the ability to replace the currently feasible harmful petroleum based plastics to biobased plastics. PHA research is being focused mainly on two facts - bulk production of environment friendly low-cost PHA and functional group modification for multiple applications to mankind. Many companies are already producing PHA with highly tunable properties and are looking into economically feasible technologies for mass production of PHA. The core focus of PHA research includes a selection of potential PHA producers and low to zero cost carbon sources such as carbon containing wastages of household, farms and industries. This challenge of “trash to treasure” still remains to attain. Tunable properties of PHA have made them a more interesting biomaterial to blend with suitable biopolymers including bioactive compounds. Under precise physiological environment, PHA blends can deliver promising mechanical properties, acting as effective drug carriers and showing time bound degradation. Perhaps desirably tuned PHA may address many health issues including orthopedics - load bearing cartilage, artificial membranes for kidneys, heart and wound management. PHA has high immunotolerance, low toxicity and sustained biodegradability, which have attracted diverse scientist with many medical advancements such as bioabsorbable sutures and 3D structures. In the near future, it is expected to derive many smart auto controllable products from PHA such as microsphere, which could be utilised for a range of applications much more than just drug delivery. Furthermore, naturally produced hybrid PHA will be an interesting candidate as they possess essential properties for targeted applications without further artificial blending or incorporating any components.

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Polyhydroxyalkanoates – what are the uses? Current challenges and perspectives

Cited by 61 publications

References 143 publications

Bioconversion of crude glycerol to polyhydroxyalkanoate by Bacillus thuringiensis under non-limiting nitrogen conditions

Bioconversion of crude glycerol to polyhydroxyalkanoate by Bacillus thuringiensis under non-limiting nitrogen conditions

Transgenic plants as a source of polyhydroxyalkanoates

Bioplastic Polyhydroxyalkanoate (PHA): Recent Advances in Modification and Medical Applications

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