Polyethylene glycol-conjugated hyaluronic acid-ceramide self-assembled nanoparticles for targeted delivery of doxorubicin

Cho, Hyun‐Jong; Yoon, Ina; Yoon, Hong Yeol; Koo, Heebeom; Jin, Yu; Ko, Seung Hak; Shim, Jae Seong; Kim, Kwangmeyung; Kwon, Ick Chan; Kim, Dae Duk

doi:10.1016/j.biomaterials.2011.10.064

Cited by 236 publications

(186 citation statements)

References 27 publications

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“…The quantities of IL-2 and IFN-γ in the plasma or tissue homogenate supernatant of the mice were determined by a Human Interleukin 2 ELISA Kit and a Human Interferon Gamma ELISA Kit (Cloud-Clone Corp., USA). The DOX concentrations in the plasma sample and the supernatant of the tumor homogenate were verifi ed by HPLC, as described previously [ 57,58 ] with minor modifi cations. A 120 µL plasma sample was deproteinized with 380 µL of acetonitrile, and 120 µL of methanol containing 1 mg mL −1 of daunorubicin hydrochloride (internal standard) was added.…”

Section: Delivery Of Il-2 Ifn-γ and Dox From Npcgs To Different Tummentioning

confidence: 99%

Nanogel‐Incorporated Physical and Chemical Hybrid Gels for Highly Effective Chemo–Protein Combination Therapy

et al. 2015

Adv Funct Materials

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Chemo-and protein-based therapeutics are two major modalities for the treatment of malignant tumors with drastically different therapeutic indices, toxicity, and other pharmacological properties. For intended in vivo applications, they also have distinctly different formulation challenges to be addressed separately. In this study, we attempt to overcome the formulation barriers of chemo-and protein-based therapeutics, and report the development of injectable nanogels, a class of crosslinked physical and chemical composite gels (

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Section: Delivery Of Il-2 Ifn-γ and Dox From Npcgs To Different Tummentioning

confidence: 99%

Nanogel‐Incorporated Physical and Chemical Hybrid Gels for Highly Effective Chemo–Protein Combination Therapy

et al. 2015

Adv Funct Materials

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“…In addition, multidrug resistance of ADM also limits its clinical applications. To overcome these limitations, loading ADM into macromolecular carriers, such as iron oxide, carboxymethylpullulan, poly (L-lysine citramide), and polyethylene glycol has attracted much attention (8)(9)(10)(11). Such delivery systems can improve ADM anticancer activity and decrease its side effects.…”

Section: Introductionmentioning

confidence: 99%

Targeted Cancer Therapy with a 2-Deoxyglucose–Based Adriamycin Complex

Cao

Cui

et al. 2013

Cancer Research

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Adriamycin (ADM) has been effective against many types of solid tumors in clinical applications. However, its use is limited because of systemic toxicities, primarily cardiotoxicity, and multidrug resistance. In this study, a new active receptor-mediated complex, ADM conjugated with 2-amino-2-deoxy-D-glucose and succinic acid (2DG-SUC-ADM), was designed to target tumor cells through glucose transporter 1 (GLUT1). MTT assay and confocal images showed that the complex had better inhibition rate to tumor cells and low toxicity to normal cells. Most importantly, the complex displayed a potential to reverse overcome multidrug resistance in cancer cells, with more complex transported into the nucleus of tumor cells. Our in vivo experiments also showed that this new complex could significantly decrease organ toxicity and enhance the antitumor efficacy compared with free ADM, indicating a promising drug of 2DG-SUC-ADM for targeted cancer therapy. Cancer Res; 73(4); 1362-73. Ó2012 AACR.

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“…Except that the fluorescence signals were shown in livers and spleens resulting from reticuloendothelial system, 46 the other organs, especially the hearts, were not observed fluorescence signals. This indicated that the mixed micelles could effectively reduce the cardiotoxicity induced by DOX.…”

Section: In Vivo Imaging Analysismentioning

confidence: 72%

Decoration of pH-sensitive copolymer micelles with tumor-specific peptide for enhanced cellular uptake of doxorubicin

Chen¹,

Long²,

Qiu³

et al. 2016

IJN

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To improve the targeting efficacy of hyaluronic acid (HA)-based micelles, pH-sensitive mixed micelles based on HA-g-poly(L-histidine) (PHis) and d-α-tocopheryl polyethylene glycol 2000 copolymers were prepared and decorated with human epidermal growth factor receptor 2 (Her2) peptide, a tumor cell-specific peptide ligand, on their surface. The doxorubicin-loaded micelles (HA-PHis/peptide–d-α-tocopheryl polyethylene glycol 2000 mixed micelles [PHTM]) were characterized to have a unimodal size distribution and pH-dependent drug release pattern. In vitro tumor targeting studies demonstrated that PHTM exhibited the pronounced cytotoxicity and efficient internalization in MDA-MB-231 cells overexpressing CD44 and Her2 receptors. In vivo investigation into micelles in MDA-MB-231 tumor-bearing mice confirmed that PTHM could reach the tumor site more effectively and exert excellent tumor killing activity. In general, Her2 peptide decoration can enhance the selective cytotoxicity and antitumor activity of HA-based micelles.

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Polyethylene glycol-conjugated hyaluronic acid-ceramide self-assembled nanoparticles for targeted delivery of doxorubicin

Cited by 236 publications

References 27 publications

Nanogel‐Incorporated Physical and Chemical Hybrid Gels for Highly Effective Chemo–Protein Combination Therapy

Nanogel‐Incorporated Physical and Chemical Hybrid Gels for Highly Effective Chemo–Protein Combination Therapy

Targeted Cancer Therapy with a 2-Deoxyglucose–Based Adriamycin Complex

Decoration of pH-sensitive copolymer micelles with tumor-specific peptide for enhanced cellular uptake of doxorubicin

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