Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties

Wang, Lixin; He, Songqing; Wu, Xiaomian; Liang, Shanshan; Mu, Zhong-Lin; Wei, Jie; Deng, Feng; Deng, Yi; Wei, Shicheng

doi:10.1016/j.biomaterials.2014.04.085

Cited by 271 publications

(203 citation statements)

References 63 publications

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“…4,5 However, there are concerns regarding the release of harmful metal ions and the radiopacity of metal alloys in vivo. 6 Moreover, the elastic moduli (over 100 GPa) of metal alloys mismatch the mechanical properties between metals and human bones resulting in bone resorption. 6,7 Carbon fiber (CF)-reinforced polyetheretherketone (CFRPEEK) is becoming a primary candidate to replace metallic implants.…”

Section: Introductionmentioning

confidence: 99%

“…6 Moreover, the elastic moduli (over 100 GPa) of metal alloys mismatch the mechanical properties between metals and human bones resulting in bone resorption. 6,7 Carbon fiber (CF)-reinforced polyetheretherketone (CFRPEEK) is becoming a primary candidate to replace metallic implants. CFRPEEK composite has an adjustable elastic modulus close to that of cortical bone (about 18-25 GPa), which can mitigate concerns over the risks of osteanabrosis and bone resorption caused by stress shielding.…”

Section: Introductionmentioning

confidence: 99%

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Effect of surface roughness on osteogenesis in vitro and osseointegration in vivo of carbon fiber-reinforced polyetheretherketone–nanohydroxyapatite composite

Deng¹,

Liu²,

Xu³

et al. 2015

IJN

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As United States Food and Drug Administration-approved implantable material, carbon fiber-reinforced polyetheretherketone (CFRPEEK) possesses an adjustable elastic modulus similar to cortical bone and is a prime candidate to replace surgical metallic implants. The bioinertness and inferior osteogenic properties of CFRPEEK, however, limit its clinical application as orthopedic/dental implants. In this study, CFRPEEK–nanohydroxyapatite ternary composites (PEEK/n-HA/CF) with variable surface roughness have been successfully fabricated. The effect of surface roughness on their in vitro cellular responses of osteoblast-like MG-63 cells (attachment, proliferation, apoptosis, and differentiation) and in vivo osseointegration is evaluated. The results show that the hydrophilicity and the amount of Ca ions on the surface are significantly improved as the surface roughness of composite increases. In cell culture tests, the results reveal that the cell proliferation rate and the extent of osteogenic differentiation of cells are a function of the size of surface roughness. The composite with moderate surface roughness significantly increases cell attachment/proliferation and promotes the production of alkaline phosphatase (ALP) activity and calcium nodule formation compared with the other groups. More importantly, the PEEK/n-HA/CF implant with appropriate surface roughness exhibits remarkably enhanced bioactivity and osseointegration in vivo in the animal experiment. These findings will provide critical guidance for the design of CFRPEEK-based implants with optimal roughness to regulate cellular behaviors, and to enhance biocompability and osseointegration. Meanwhile, the PEEK/n-HA/CF ternary composite with optimal surface roughness might hold great potential as bioactive biomaterial for bone grafting and tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of surface roughness on osteogenesis in vitro and osseointegration in vivo of carbon fiber-reinforced polyetheretherketone–nanohydroxyapatite composite

Deng¹,

Liu²,

Xu³

et al. 2015

IJN

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“…Combined with the specific progenitor cell population, a scaffold supplied with differentiation factors (DF) can regulate the dimensional and temporal organization of the cell adhesion, growth, differentiation, and function as the osteogenic expression in tissue engineering [2,3]. Nevertheless, on account of bacteria colonization and toxin-release, it can be definitely deduced that the therapeutic implants and nearby tissue will suffer from disastrous post-operative complications, including, for instance, abnormal allergic and infectious reactions, consequently resulting in implant failure [4]. Thus, there is an urgent demand for a functional implant material whose surface is designed to possess both antibacterial and osteogenesis competences, for further enhancement of post-operative success rates.…”

Section: Introductionmentioning

confidence: 99%

Osteogenesis and Antibacterial Activity of Graphene Oxide and Dexamethasone Coatings on Porous Polyetheretherketone via Polydopamine-Assisted Chemistry

Ouyang

Wang

et al. 2018

Coatings

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Endowing implants with antibacterial ability and osteogenic ability plays important roles in preventing post-operative bacterial contamination and facilitating integration between implants and osseous tissue, consequently reducing implant failure rates. In this study, we develop a facile and versatile strategy with dopamine as an auxiliary for construction of dexamethasone (Dex)/liposome porous coatings. In detail, the surfaces of sulfonated polyetheretherketone (SP) plates are coated with polydopamine firstly and then modified with graphene oxide (GO) and dexamethasone (Dex)-loaded liposome, which is verified by contact angle, X-ray photoelectron spectroscopy (XPS), attenuated total reflection infrared (ATR), and Raman spectra. The results of our study suggest that the GO and Dex are successfully coated on the samples' surfaces. In vitro cell attachment, growth, differentiation, and apatite deposition tests all illustrate that the substrate coated with GO and Dex can significantly accelerate the proliferation and osteogenic differentiation of MC3T3 cells compared with the pristine sulfonated polyetheretherketone (PEEK). Additionally, it exhibits acceptable antibacterial activity against E. coli and S. aureus in vitro. Altogether, our results demonstrate that the modified GOand Dex-loaded substrates are endowed with impressive biocompatibility and certain antibacterial qualities, making it possible for future application as a perspective implant material.

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“…29 Lately, recent advances in dental materials have involved the incorporation of nano-sized particles and surface modifications to improve their mechanical and biological properties of dental implants, directive restorative materials and tissue regenerative materials. [1][2][3][4]30 Some examples of nano-sized particles that have been used in dentistry are: bioceramics such as hydroxyapatite (HA) 31-36 fluorohydroxyapatite [37][38][39] (FHA) and bioglass 40,41 for implantmodification and guided tissue regeneration and nano-sized fillers such as silica and alumina to improve the mechanical and optical properties of restorative materials. 42,43 .…”

Section: Accepted Version Science Of Advanced Materialsmentioning

confidence: 99%

Dental Applications of Nanodiamonds

Najeeb¹,

Khurshid²,

Agwan³

et al. 2016

sci adv mater

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Nanodiamonds (NDs) have been used in various fields of medicine such as drug delivery, tissue regeneration and gene therapy. Although there has been research carried out investigated the potential of these remarkable materials in dentistry, to date no review has been published to summarize the studies conducted.Due to their target cell specificity, small size and fluorescence they have also been found to be usefulness in dentistry. Main applications of NDs in dentistry and medicine include guided tissue regeneration, reinforcement of polymers and drug delivery to treat infections and cancers. Recent research also suggests that NDs can also be used as bioactive or antibacterial dental implant coatings. However, to date, the research conducted on their biocompatibility is limited and inconclusive. Hence, substantially more in vitro and in vivo studies are required to envisage the future of NDs in dentistry. It is hoped that in the next decade these promising materials will find a variety of uses in routine dentistry.

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Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties

Cited by 271 publications

References 63 publications

Effect of surface roughness on osteogenesis in vitro and osseointegration in vivo of carbon fiber-reinforced polyetheretherketone–nanohydroxyapatite composite

Effect of surface roughness on osteogenesis in vitro and osseointegration in vivo of carbon fiber-reinforced polyetheretherketone–nanohydroxyapatite composite

Osteogenesis and Antibacterial Activity of Graphene Oxide and Dexamethasone Coatings on Porous Polyetheretherketone via Polydopamine-Assisted Chemistry

Dental Applications of Nanodiamonds

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Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties

Cited by 271 publications

References 63 publications

Effect of surface roughness on osteogenesis in&nbsp;vitro and osseointegration in vivo of carbon fiber-reinforced polyetheretherketone&ndash;nanohydroxyapatite composite

Effect of surface roughness on osteogenesis in&nbsp;vitro and osseointegration in vivo of carbon fiber-reinforced polyetheretherketone&ndash;nanohydroxyapatite composite

Osteogenesis and Antibacterial Activity of Graphene Oxide and Dexamethasone Coatings on Porous Polyetheretherketone via Polydopamine-Assisted Chemistry

Dental Applications of Nanodiamonds

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Product

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Effect of surface roughness on osteogenesis in vitro and osseointegration in vivo of carbon fiber-reinforced polyetheretherketone–nanohydroxyapatite composite

Effect of surface roughness on osteogenesis in vitro and osseointegration in vivo of carbon fiber-reinforced polyetheretherketone–nanohydroxyapatite composite