Polyelectrolyte nanoparticles based on water-soluble chitosan–poly(l-aspartic acid)–polyethylene glycol for controlled protein release

A physico-chemical and biological study of novel chitosan–chloroquinoline derivative for biomedical applications

“…Chitosan is biocompatible, biodegradable, low toxicity, remarkable affinity to proteins, which helps attract increasing attention in the fields of textile, food, agriculture, cosmetics, biomedical, pharmaceutical, and other industries [1][2][3][4][5][6][7][8][9]. Recently, chitosan has been reported to be used as a material for drug delivery [10,11] optical [12], and tissue engineering applications [7,13,14]. The quinoline ring system is an important structural unit in alkaloids, therapeutics and synthetic analogues with interesting pharmacological and biological activities such as antimalarial, antibacterial, antiasthmatic, anti-hypertensive, anti-inflammatory, HIV, tumor and tyrosine kinase inhibiting agents [15][16][17][18][19][20][21][22].…”

Nanopreparations for Oral Administration

“…88 Substantial research has been conducted on the oral delivery of insulin using chitosan as a nanocarrier. [89][90][91][92] Many of these have utilized the mild ionic gelation techniques that can maintain insulin's three-dimensional structure. In one example, nanopreparations were synthesized by ionotropic gelation in the size range of 250-400 nm using 88.9% deacetylated chitosan.…”

Synthesis, characterisation and in vitro evaluation of novel thiolated derivatives of polyallylamine and quaternised polyallylamine

“…The formation of disulphide crosslinks by thiolated groups attached to the quaternised thiomers could have been impeded by the bulky quaternary ammonium groups present on the polymer backbone sterically limiting inter-chain thiol-disulphide interactions, as the close proximity of interacting thiol groups has been shown to improve the crosslinking process [44]. The tendency of Paa-TBA to form an in-situ crosslinked network at physiological pH would be considered advantageous as such crosslinked systems have been used in various drug delivery applications due to their ability to offer controlled (pH-dependent) release of incorporated materials as well as extend the residence of dosage forms at the site of application [19,20,45,46].…”