Polycythemia With an Unusual Eruption

Eosinophilic spongiosis in association with bullous pemphigoid and chronic lymphocytic leukaemia

“… 1 It is interesting that there have been a few reports of its association with polycythaemia rubra vera, a myeloproliferative disorder of red blood cells, and in all three cases the cutaneous presentation was that of a vesicular eruption. 15–17 …”

Eosinophilic spongiosis: a localized bullous dermatosis unassociated with pemphigus

“…The three cases described by Knight et aL (1976) in which immunofluorescence was negative were a 49-year-old woman with a severe bullous eruption simulating erythema multiforme; an 82-year-old woman with widespread turgid erythematous plaques, which cleared spontaneously after a few weeks; and an itchy herpetiform eruption on the trunk which was associated with polycythaemia rubra vera (PRV) (Black, 1977). Two other cases of eosinophilic spongiosis apparently associated with PRV have been published (Strickler, 1945;Fry, 1965), and although immunofluorescence techniques were unavailable at the time they were reported, from the data provided it is unlikely that the cases had pemphigus. All examples of eosinophilic spongiosis so far reported have had widespread eruptions, in contrast to the hmited distribution of blistering seen in the two cases described here.…”

Eosinophilic spongiosis. A CLINICAL HISTOLOGICAL AND IMMUNOFLUORESCENT CORRELATION

“…She also had polycythemia rubra vera. Strickler (1945) and Fry (1965) have described two patients also with polycythaemia who developed a vesicular eruption simulating dermatitis herpetiformis. The question is posed as to whether these latter patients will eventually develop pemphigus, or are they suffering from some other, as yet unclassifiable, bullous disease ?…”