Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis

Abstract

BackgroundThe association between depression, anxiety, and polycystic ovary syndrome (PCOS) is still unclear. Therefore, a systematic review and meta-analysis was conducted to assess the rates of comorbid psychiatric disorders among women with PCOS compared to women without it.MethodsPubMed/MEDLINE, Embase, PsycINFO, and Web of Science databases were searched from inception to November 27, 2015. Studies were eligible for inclusion if they were original reports in which the rates of mood (bipolar disorder, dysthymia, or major depressive disorder), obsessive–compulsive spectrum disorders, trauma- and stressor-related disorders, anxiety disorders or psychotic disorders, somatic symptom and related disorders, or eating disorders had been investigated among women with an established diagnosis of PCOS and compared with women without PCOS. Psychiatric diagnosis should have been established by means of a structured diagnostic interview or through a validated screening tool. Data were extracted and pooled using random effects models.ResultsSix studies were included in the meta-analysis; of these, five reported the rates of anxiety and six provided data on the rates of depression. The rate of subjects with anxiety symptoms was higher in patients with PCOS compared to women without PCOS (odds ratio (OR) =2.76; 95% confidence interval (CI) 1.26 to 6.02; Log OR =1.013; P=0.011). The rate of subjects with depressive symptoms was higher in patients with PCOS compared to women without PCOS (OR =3.51; 95% CI 1.97 to 6.24; Log OR =1.255; P<0.001).ConclusionAnxiety and depression symptoms are more prevalent in patients with PCOS.

Deciphering the multi-scale mechanisms ofTephrosia purpureaagainst polycystic ovarian syndrome (PCOS) and its major psychiatric comorbidities: studies from network-pharmacological perspective

“…343. Although the direct association of this disease with PCOS is less explored, a large number of studies have related PCOS with various mental as well as psychiatric disorders (Blay, Aguiar, & Passos, 2016;Hung et al, 2014). While the PCOS genes are associated with 2,403 diseases, high degree of interconnections apart from the schizophrenia were found with C0006142 (breast cancer), C0376358 (prostate cancer), C0033578 (prostate cancer) and C3714756 (Intellectual disability/ mental retardation) via 69, 63, 63 and 56 PCOS proteins, respectively.…”

Prevalence of Self-reported Polycystic Ovary Syndrome and Profiles of Health Among Women of Different Generations: A Cross Sectional Study

“…There is some evidence that women with PCOS perceive their health to be poor (Bazarganipour et al, 2013) and their lifestyle behaviours are less healthy than those of their peers (Lin et al, 2018) which may also contribute to agerelated deterioration in health (Echiburu et al, 2016). Among young women with PCOS, poor mental health and emotional distress has consistently been documented (Barry et al, 2011;Blay et al, 2016;Dokras et al, 2011Dokras et al, , 2012Veltman-Verhulst et al, 2012) but it is unclear whether psychological problems prevail with age.…”

The effect of progressive muscle relaxation on depression in polycystic ovarian syndrome

“…These symptoms can also contribute to psychological impairment. 3 Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder, characterized by chronic oligomenorrhea, hyperandrogenism and insulinresistance. 4 Clinicians should be cognizant that since PCOS is associated with significant metabolic and psychological co morbidity and screening should be executed properly.…”