Polycystic Ovary Syndrome: A Connection to Insufficient Milk Supply?

Marasco, Lisa; Marmet, Chele; Shell, E Mackenzie

doi:10.1177/089033440001600211

Cited by 45 publications

(29 citation statements)

References 20 publications

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“…Women with diabetes and those who give birth by Caesarean section may be more likely to experience delayed lactogenesis or low milk supply [60-62]. Some women with PCOS have insufficient milk supply, which is thought to be related to the endocrinological changes associated with the syndrome (high levels of androgens, insulin resistance, frequently low progesterone levels) [23]. …”

Section: Discussionmentioning

confidence: 99%

A systematic review of maternal obesity and breastfeeding intention, initiation and duration

Amir

Donath

2007

BMC Pregnancy Childbirth

433

334

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Background: Breastfeeding behaviour is multifactorial, and a wide range of socio-cultural and physiological variables impact on a woman's decision and ability to breastfeed successfully. An association has been reported between maternal obesity and low breastfeeding rates. This is of public health concern because obesity is rising in women of reproductive age and the apparent association with increased artificial feeding will lead to a greater risk of obesity in children. The aim of this paper is to examine the relationship between maternal overweight and obesity and breastfeeding intention and initiation and duration.

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Section: Discussionmentioning

confidence: 99%

A systematic review of maternal obesity and breastfeeding intention, initiation and duration

Amir

Donath

2007

BMC Pregnancy Childbirth

433

334

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“…Polycystic ovary syndrome (PCOS) is a common condition, and is associated with reduced fertility; however, most women with PCOS become pregnant and give birth 1,2 . Except for one case report and one pilot study, 3,4 little has been reported about PCOS and breastfeeding. For years, the clinical impression has been that fewer women with PCOS were breastfeeding, and in a small pilot study we found support for this observation 4 .…”

Section: Introductionmentioning

confidence: 99%

Breast size increment during pregnancy and breastfeeding in mothers with polycystic ovary syndrome: a follow‐up study of a randomised controlled trial on metformin versus placebo

Vanky

Nordskar

Leithe

et al. 2012

BJOG

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Objective To study the significance of breast size increment in pregnancy, and the impact of metformin during pregnancy on breastfeeding in women with polycystic ovary syndrome (PCOS).Design A follow-up study of a randomised controlled trial (the PregMet study).Setting Eleven secondary care centres.Population Women with PCOS during pregnancy and postpartum.Methods Women with PCOS were randomised to treatment with metformin or placebo from the first trimester to delivery. Questionnaires were sent to 240 participants 1 year postpartum: 186 responded.Main outcome measures Pre-pregnancy and late-pregnancy brassiere size and breastfeeding patterns were registered, and androgen levels were measured in the mothers.Results No difference in breast size increment and breastfeeding were found between the placebo and metformin groups.Breast size increment correlated positively with the duration of both exclusive and partial breastfeeding, whereas body mass index (BMI) correlated negatively with the duration of partial breastfeeding. Dehydroepiandrostenedione-sulphate (DHEAS), testosterone and free testosterone index (FTI) in pregnancy did not correlate with breast size increment or duration of breastfeeding. Women with no change in breast size were more obese, had higher blood pressure, serum triglycerides and fasting insulin levels, and had a shorter duration of breastfeeding compared with those with breast size increment.Conclusions Metformin and androgens had no impact on breastfeeding. Women with PCOS who had no breast size increment in pregnancy seem to be more metabolically disturbed and less able to breastfeed.Keywords Androgens, breast size increment, breastfeeding, metformin, polycystic ovary syndrome, pregnancy.Please cite this paper as: Vanky E, Nordskar J, Leithe H, Hjorth-Hansen A, Martinussen M, Carlsen S. Breast size increment during pregnancy and breastfeeding in mothers with polycystic ovary syndrome: a follow-up study of a randomised controlled trial on metformin versus placebo.

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“…It has been reported that the incidence of failure to lactate in the general population is 2–15% and has a multifactorial background . No woman in our cohort had risk factors, such as cosmetic breast surgery, treatment for breast malignancy and diagnosis of polycystic ovary syndrome …”

Section: Discussionmentioning

confidence: 71%

Prolactin insufficiency but normal thyroid hormone levels after cranial radiotherapy in long‐term survivors of childhood leukaemia

Follin

Link

Wiebe

et al. 2013

Clinical Endocrinology

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Polycystic Ovary Syndrome: A Connection to Insufficient Milk Supply?

Cited by 45 publications

References 20 publications

A systematic review of maternal obesity and breastfeeding intention, initiation and duration

A systematic review of maternal obesity and breastfeeding intention, initiation and duration

Breast size increment during pregnancy and breastfeeding in mothers with polycystic ovary syndrome: a follow‐up study of a randomised controlled trial on metformin versus placebo

Prolactin insufficiency but normal thyroid hormone levels after cranial radiotherapy in long‐term survivors of childhood leukaemia

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