Polycystic ovarian syndrome and the risk of subsequent primary ovarian insufficiency: a nationwide population-based study

Pan, Mei Lien; Chen, Li Ru; Tsao, Hsiao Mei; Chen, Kuo Hu

doi:10.1097/gme.0000000000000832

Cited by 15 publications

(9 citation statements)

References 28 publications

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“…POI classification is based on the detection of signaling defects, autoimmunity, insufficient initial follicle number, genomic defects, and chemotherapy [ 23 ]. A previous report showed that POI incidence is higher among women with PCOS than in women without PCOS (3.73% vs. 0.44%) [ 24 ]. PCOS patients experience interruption of follicle development, resulting in the formation of cysts and eventually follicle depletion.…”

Section: Discussionmentioning

confidence: 99%

Welsh Onion Root (Allium fistulosum) Restores Ovarian Functions from Letrozole Induced-Polycystic Ovary Syndrome

et al. 2018

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Polycystic ovarian syndrome (PCOS) is an endocrine, metabolic, and systemic disease. It is mainly characterized by hyperandrogenism, oligomenorrhea, and high levels of luteinizing hormone (LH). There is no obvious therapy for PCOS, so patients have received symptomatic therapy. Welsh onion (Allium fistulosum) is well-known in Asian countries for its usage in food ingredients and traditional medicines. It is also studied for its many effects. These include activation of immune responses, antihypertensive effects, and antioxidant effects. Using letrozole-induced PCOS rats, we focused on herbal therapy using extract of Allium fistulosum (AF; A. fistulosum) roots to improve ovarian functions. As a nonsteroidal aromatase inhibitor, letrozole blocks conversion of testosterone to estrogen and subsequently induces PCOS phenomenon. We divided six-week-old female rats into four groups, including control, letrozole, letrozole + AF extract, and temporary letrozole groups. In our study, treatment with AF extract shows a low plasma LH/FSH ratio, and reveals high estrogen levels, ovarian morphology, folliculogenesis-related genes, and aromatase expression under PCOS mimic conditions. We concluded that AF extract administration influenced aromatase production, enhanced the estrogen steroid synthesis, and consequently restored the estrogenic feedback mechanism on the pituitary-ovary system.

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Section: Discussionmentioning

confidence: 99%

Welsh Onion Root (Allium fistulosum) Restores Ovarian Functions from Letrozole Induced-Polycystic Ovary Syndrome

et al. 2018

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“…7 ). Since Rps26 was susceptibility to PCOS, and PCOS patients have higher risk for POF 38 . It seemed that our research mimics the process in which PCOS finally leads to POF.…”

Section: Discussionmentioning

confidence: 99%

Loss of oocyte Rps26 in mice arrests oocyte growth and causes premature ovarian failure

Liu

Yan

et al. 2018

Cell Death Dis

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Global transcriptional activity increases as oocytes grow and is silenced in fully grown oocytes. Thus, the chromatin configuration varies during oocyte growth, but the molecular mechanisms regulating these changes remain to be clarified. Here, we studied a susceptibility gene of polycystic ovary syndrome (PCOS), RPS26, which is a ribosomal protein-encoding gene that is highly expressed in the ovary, but the functions of which remain unknown. Specific knockout of Rps26 in mouse oocytes resulted in retarded follicle development from pre-antral follicles to antral follicles, while the chromatin configurations of the oocytes were arrested at the transition from the non-surrounded nucleolus (NSN) to surrounded nucleolus (SN)-type. As a consequence, all oocytes died by postnatal day 84 resulting in premature ovarian failure (POF). Loss of Rps26 in oocytes led to decreased mRNA transcription and low levels of histone trimethylation on H3K4/H3K9 and DNA methylation at 5-cytosine, high levels of which are required for oocytes to transform from NSN to SN-type. Low protein levels of oocyte-derived growth differentiation factor 9, bone morphogenetic protein 15, and the oocyte-granulosa cell gap junction protein connexin 37 inhibited oocyte growth and retarded follicle development. The disruption of the phosphoinositide 3-kinase/protein kinase B/Forkhead box O-3a pathway contributed to oocyte death and follicle atresia. These results provide genetic clues for the clinical diagnosis of POF, especially in PCOS patients without treatment.

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“…выяснено, что частота встречаемости ПНЯ у лиц с СПКЯ составляет 3,73 % против 0,44 % у женщин без этой патологии. В связи с этим авторы предлагают рассматривать СПКЯ как начальную стадию развития ПНЯ [20].…”

Section: заболевания репродуктивной системы / Diseases Of the Reproductive Systemunclassified

Assessment of risk factors and prediction of premature ovarian failure

Tkachenko

Gritsenko

Tikhaeva

et al. 2022

Akušerstvo, ginekologiâ i reprodukciâ

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The problem of premature ovarian failure (POF) is currently in the spotlight of obstetricians and gynecologists worldwide. Early diagnosis of this pathology is necessary to prevent the development of serious pathological conditions. The systematization of modern ideas about laboratory and instrumental methods for POF diagnosing, assessing diagnostic value of parameters such as follicle stimulating hormone, anti-Mullerian hormone as well as the count of antral ovarian follicles, intraovarian blood flow and ovarian volume using ultrasound techniques, which can then be used as prognostic criteria for POF comprise a very important modality. Based on the findings obtained, early detection may lead to proposing new prognostic strategies.

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Polycystic ovarian syndrome and the risk of subsequent primary ovarian insufficiency: a nationwide population-based study

Abstract: As a possible precursor stage, prior PCOS is a significant and independent risk factor for development of POI. The use of metformin reduces the risk of POI.

Cited by 15 publications

References 28 publications

Welsh Onion Root (Allium fistulosum) Restores Ovarian Functions from Letrozole Induced-Polycystic Ovary Syndrome

Welsh Onion Root (Allium fistulosum) Restores Ovarian Functions from Letrozole Induced-Polycystic Ovary Syndrome

Loss of oocyte Rps26 in mice arrests oocyte growth and causes premature ovarian failure

Assessment of risk factors and prediction of premature ovarian failure

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