Polycystic (Dysgenetic) Disease of the Parotid Glands

Dysgenetic Polycystic Disease of Minor Salivary Gland: A Rare Case Report and Review of the Literature

“… Histologically the lesion shows multiple ductal ectasias resembling a mucous retention cyst. The presence of microliths/spheroliths histologically has been reported by Seifert et al (1981), Batsakis et al (1988), Brown et al (1995), and Layfield and Gopez (2002) [ 3 , 5 , 8 , 12 ]. The presence of multiple sialoliths may lead to mucous retention phenomenon presenting with a “polycystic” nature histologically.…”

“…There is flocculent, eosinophilic material and a few scattered macrophages found in most of the cystic lumina. Along with this many cysts contain eosinophilic bodies with concentric and radial patterns that resemble spheroliths and microliths that have been reported in 6 cases [ 3 , 5 , 12 ].…”

“…Certain clinical characteristics are deemed to be unique to this lesion when it presents in the major salivary glands. These include history of a recurrent, asymptomatic swelling of the involved gland and no association with any clinical abnormality of salivation or anomaly of salivary gland, presence of enlarged, nontender bilateral parotid swelling for months or years: Batsakis et al (1988) described the histologic findings in three female patients with this disorder, two of which had bilateral parotid swelling since childhood, and one had unilateral swelling since puberty and subsequently developed swelling of the other gland during young adulthood [ 5 ]. Garcia et al (1998) reported the first case affecting the submandibular gland bilaterally (French literature) [ 11 ], recurrent parotid swelling often occurring in childhood, while symptoms of this disorder might be delayed until adulthood [ 8 ].…”

“…presence of enlarged, nontender bilateral parotid swelling for months or years: Batsakis et al (1988) described the histologic findings in three female patients with this disorder, two of which had bilateral parotid swelling since childhood, and one had unilateral swelling since puberty and subsequently developed swelling of the other gland during young adulthood [ 5 ]. Garcia et al (1998) reported the first case affecting the submandibular gland bilaterally (French literature) [ 11 ],…”

Polycystic disease of salivary glands

“…Other cystic lesions in salivary glands include branchiogenic cysts, sialectasis, mucous retention cysts and polycystic disease. This latter condition is extremely rare: only eight cases have been described with full histological proof (Seifert et al, 1981;Dobson and Ellis, 1987;Batsakis et al, 1988;Smyth et al, 1993). We present a further case of polycystic disease of a salivary gland, though this example occurred in an aberrant salivary gland and is the first reported case not to arise within the parotid gland.…”