Polycyclic aromatic hydrocarbons affect the calcium ionophore induced activation of rabbit platelet

Yamazaki, Hiroyasu; Imamura, Eiko; Kamei, Sumi; Yamauchi, Aiko; Kakiuchi, Yasuo; Tai, Hsin‐Hsiung

doi:10.1016/0045-6535(90)90373-2

Cited by 6 publications

(6 citation statements)

References 12 publications

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“…This suggestion is partially supported by a previous study finding that diesel exhaust particle extract and associated PAHs inhibited the COX-2 activity in vitro but do not inhibit the activity of COX-1 . In addition, in vitro exposure of rabbit platelets to pyrene and anthracene induced production of TXB 2 via a calcium carrier-dependent mechanism, supporting our findings of a particularly strong association between 1-AP and 11-dhTXB 2 . The current findings call for further investigations on the effects of nitro-PAH exposure on COX enzymes and associated health consequences.…”

Section: Discussionsupporting

confidence: 90%

“…55 In addition, in vitro exposure of rabbit platelets to pyrene and anthracene induced production of TXB 2 via a calcium carrierdependent mechanism, supporting our findings of a particularly strong association between 1-AP and 11-dhTXB 2 . 56 The current findings call for further investigations on the effects of nitro-PAH exposure on COX enzymes and associated health consequences. TXA 2 , as a vasoconstrictor, may be an important link in the mechanism by which nitro-PAH exposures can induce cardiovascular disorders.…”

Section: Discussionmentioning

confidence: 82%

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Nitrated Polycyclic Aromatic Hydrocarbons and Arachidonic Acid Metabolisms Relevant to Cardiovascular Pathophysiology: Findings from a Panel Study in Healthy Adults

Lin

Day³

et al. 2021

Environ. Sci. Technol.

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Concerns on nitrated polycyclic aromatic hydrocarbons (nitro-PAHs) in the environment have mainly arisen from their mutagenic and carcinogenic effects. The objective of this study is to investigate whether nitro-PAH exposures are associated with biomarkers of cardiovascular pathophysiology. In a panel study design, urines and blood samples were collected up to four times with a 2-week interval from 89 healthy adults. We measured 1-naphthylamine, 2-naphthylamine, 9-aminophenanthrene, 2-aminofluorene, and 1-aminopyrene as biomarkers of nitro-PAH exposures. We measured three urinary metabolites of arachidonic acid (AA) including 20-hydroxyeicosatetraenoic acid (20-HETE) from the cytochrome P450 (CYP) pathway, 8-isoprostane from the nonenzymatic pathway, and 11-dehydro-thromboxane B2 (11-dhTXB2) from the cyclooxygenase (COX) pathway. Urinary malondialdehyde, 8-hydroxy-2′-deoxyguanosine (8-OHdG), and 6-sulfatoxymelatonin (aMT6s) were measured to reflect systemic oxidative stress. Plasma concentrations of the soluble P-selectin and von Willebrand factor (vWF) were measured as biomarkers of platelet activation and endothelial dysfunction. We found that increased urinary concentrations of amino-PAHs were significantly associated with increased 20-HETE, 11-dhTXB2, and 8-OHdG and with decreased 8-isoprostane and aMT6s. Increased amino-PAHs were positively associated with P-selectin and vWF, respectively. These results suggest that exposure to nitro-PAHs increases systemic oxidative stress and alters AA metabolism toward CYP and COX pathways, leading to an increased cardiovascular disease risk.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 82%

Nitrated Polycyclic Aromatic Hydrocarbons and Arachidonic Acid Metabolisms Relevant to Cardiovascular Pathophysiology: Findings from a Panel Study in Healthy Adults

Lin

Day³

et al. 2021

Environ. Sci. Technol.

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“…In mice, 13-week administration of fluoranthene and fluorine can decrease Hb and PCV (EPA 1989). Another study by Yamazaki et al (1990) showed the influence of PAHs on Ca + 2 -ionophore-induced isolated platelet of rabbit in which B(a)A, Chry, B(a)P and B(ghi)P inhibited thromboxane B 2 synthesis when incubated with stimulated platelets. On the contrary, the Pyr and Ant stimulated the synthesis of thromboxane B 2 , which indicates both stimulating and inhibiting effects of PAHs at different concentrations.…”

Section: Salvi and Barnes 2010mentioning

confidence: 99%

A review of PAH exposure from the combustion of biomass fuel and their less surveyed effect on the blood parameters

Kamal

Cincinelli

Martellini

et al. 2014

Environ Sci Pollut Res

117

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Many epidemiological studies from all over the world have reported that populations of rural and urban environments differ in their health issues due to the differences in the countrywide pollution pattern. In developing countries, various occupational cohorts and subsections of the population in urban and rural areas are routinely exposed to several environmentally widespread contaminants. Polycyclic aromatic hydrocarbons (PAHs) are a group of over hundred different compounds and have ubiquitous presence in rural and urban environments. Smoke from the combustion of biomass fuel contains a high concentration of carcinogenic PAHs, which are related with several human morbidities. The sources and types of biomass fuel are diverse and wide in distribution. Limited numbers of literature reports have focused the significant impact of PAHs on several components of blood, both in human and wildlife. The toxicity of PAHs to rapidly dividing cells (e.g., bone marrow cells) and other tissues is largely attributed to their reactive oxygenated metabolites, potential of causing oxidative stress, and the adducts of their metabolites with DNA. This review aims to encompass the blood-related effects of PAHs and associated human health risks-an aspect that needs further research-on the population of developing countries of the world in particular.

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“…In addition, it has been shown that benzo [a]pyrene is toxic to cultured bone marrow cells when applied directly (Legraverend et al 1983) PAHs appear to affect other blood elements, as well. The influence of several PAHs on calcium ionophore-induced activation of isolated rabbit platelets was studied (Yamazaki et al 1990 However, no statistical analysis was performed on these data, and the changes reported are generally within ±10% of control values. In addition, the effects of the PAHs on thromboxane B 2 synthesis are bidirectional, and in many instances, the same compound induced both inhibition and stimulation at different concentrations.…”

Section: Dermal Mrlsmentioning

confidence: 99%

The Gulf Oil Spill

2011

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Polycyclic aromatic hydrocarbons affect the calcium ionophore induced activation of rabbit platelet

Cited by 6 publications

References 12 publications

Nitrated Polycyclic Aromatic Hydrocarbons and Arachidonic Acid Metabolisms Relevant to Cardiovascular Pathophysiology: Findings from a Panel Study in Healthy Adults

Nitrated Polycyclic Aromatic Hydrocarbons and Arachidonic Acid Metabolisms Relevant to Cardiovascular Pathophysiology: Findings from a Panel Study in Healthy Adults

A review of PAH exposure from the combustion of biomass fuel and their less surveyed effect on the blood parameters

The Gulf Oil Spill

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