Polyclonal B-Cell activation byNeisseria meningitidis capsular polysaccharides elicit antibodies protective againstTrypanosoma cruzi infection in vitro

The effect of pneumococcal immunization on total and antigen-specific B cells in patients with severe chronic kidney disease

“…Polyclonal stimulation of memory B cells, which causes their proliferation and differentiation into plasma cells, helps to maintain serological memory throughout life [45]. Polyclonal B cell activation by capsular polysaccharides of Neisseria meningitidis was previously reported by Oliveira et al (1996) [46].…”

BCR repertoire sequencing: different patterns of B‐cell activation after two Meningococcal vaccines

“…It therefore appears that either there is a degree of selection for incorporation into the HLA‐DR – compartment, or that there are certain common antigens that all individuals are exposed to during the course of their lifetime and sequences against these common antigens dominate the HLA‐DR – compartment. Another possibility is that in addition to vaccine‐specific PCs in the HLA‐DR + population, additional inter‐individual variation arises from the presence of PCs generated in incidental responses against non‐vaccine antigens or because of ‘bystander stimulation’ 39 . Perhaps the most compelling evidence we have of the HLA‐DR + and HLA‐DR – PCs comprising distinct populations is that when analyzing, which baseline B‐cell subsets are activated to produce the IgG PCs, we see differences between the vaccine groups for the HLA‐DR + , but not the HLA‐DR – PCs.…”

“…Another possibility is that in addition to vaccine-specific PCs in the HLA-DR + population, additional inter-individual variation arises from the presence of PCs generated in incidental responses against non-vaccine antigens or because of 'bystander stimulation'. 39 Perhaps the most compelling evidence we have of the HLA-DR + and HLA-DR -PCs comprising distinct populations is that when analyzing, which baseline B-cell subsets are activated to produce the IgG PCs, we see differences between the vaccine groups for the HLA-DR + , but not the HLA-DR -PCs. This indicates that the HLA-DR + population is enriched for vaccine specificity, allowing us to detect these differences, but the HLA-DRpopulation is not.…”

Vaccination of cattle against the Boophilus microplus using a mucin‐like membrane glycoprotein

“…The antigenicity of the mucins is well established in other organisms and tissues, particularly in the case of cancer immunotherapy (for example Apostolopoulos, McKenzie & Pietersz 1996, Graham, Burchell & Taylorpapadimitriou 1996. There is evidence that cross-reactive antibodies to Neisseria meningitidis capsular polysaccharide may both react with a mucin-like molecule from trypomastigotes and cross-protect (Oliveira, Milani & Travassos 1996). In view of the importance of the question whether protection against ticks resides with oligosaccharide or protein epitopes, it is interesting that there is evidence that for the MUC-1 mucin, both may be important (Koganty, Reddish & Longenecker 1996).…”