Polychromatic light (480–3400nm) similar to the terrestrial solar spectrum without its UV component in post-surgical immunorehabilitation of breast cancer patients

Zhevago, Natalia A.; Zimin, A.A.; Глазанова, Т В; Давыдова, Н. И.; Бычкова, Н. В.; Чубукина, Ж В; Buinyakova, Anna I.; Ballyuzek, Marina F.; Samoilova, K.A.

doi:10.1016/j.jphotobiol.2016.10.040

Cited by 7 publications

(7 citation statements)

References 18 publications

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“…In this way, the inflammatory processes can be limited, and the reparative phase triggers. Our results may, in part, explain the healing of the wounded area and the improvement in chronic inflammatory processes, previously observed by us [12] and other researches [8][9][10][11][17][18][19][20][21][22] in vivo.…”

Section: Discussionsupporting

confidence: 80%

“…Only a few experiments have been performed using PILER radiation to analyze variations in immunological parameters in different physiological or pathological conditions, such as number of leukocytes, phagocytic capability of neutrophils and macrophages, blood plasma immunoglobulin concentrations, lymphocyte subpopulations, NK and CD8 + T cells cytotoxic activity, and blood serum cytokine levels [17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Irradiation with Polychromatic Incoherent Low Energy Radiation of Human Peripheral Blood Mononuclear Cells In Vitro: Effects on Cytokine Production

Salmeri

Denaro

Ruello

et al. 2020

IJERPH

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(1) Background: Physical stimuli may activate peripheral blood mononuclear cells (PBMCs) to secrete cytokines, which may favor pro-inflammatory responses or trigger reparative phenomena. The purpose of this study is to evaluate the action of Polarized Polychromatic Incoherent Low Energy Radiation (PILER) on human in vitro PBMCs, by detection of the possible effects on cytokine production; (2) Methods: isolated PBMCs were irradiated with a PILER lamp at different exposure times, at a distance of 10 cm, before incubation. The supernatants were collected after 24 h and 48 h and cytokines evaluated by ELISA; (3) Results: Our results showed a decrease in the levels of pro-inflammatory IL-12p70, IL-17A, IFN-γ, and TNF-α cytokines, whereas IL-10 and TGF-β1 with regulatory activity increased; (4) Conclusions: PILER irradiation affected the cytokine production by isolated PBMCs driving the immune response toward an anti-inflammatory/reparative profile.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Irradiation with Polychromatic Incoherent Low Energy Radiation of Human Peripheral Blood Mononuclear Cells In Vitro: Effects on Cytokine Production

Salmeri

Denaro

Ruello

et al. 2020

IJERPH

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“…O infravermelho também foi aplicado com bons resultados em estudo com 19 pacientes, que revelou síntese de radicais livres disponibilizados na circulação sanguínea, permitindo assim a regeneração tecidual, com a deposição de colágeno no local da cicatrização, evitando eventuais complicações pós-operatórias como, por exemplo, a deiscência cicatricial, que gera dor e restrição de mobilidade do ombro 6 . Neste estudo, o comprimento de onda utilizado foi de 480-3400 nm, apresentando uma faixa de comprimento de onda amplo; enquanto, no artigo de Study e Emitting 13 , o comprimento de onda foi apenas de 540 nn por 30 minutos.…”

Section: Discussionunclassified

“…Entre as condutas fisioterapêuticas para tratar as disfunções provenientes da mastectomia, está a fototerapia, que consiste na utilização da luz para fins terapêuticos. Cromóforos presentes na pele captam o estímulo luminoso e desencadeiam a fotobiomodulação no interior celular, a fim de promover efeito analgésico, antiedematoso, anti--inflamatório e cicatrizante 6,7 .…”

Section: Introductionunclassified

Fototerapia Pós-Mastectomia: uma Revisão Sistemática

Rocha¹,

Lemos

Ribeiro³

2019

Rev. Brasileira.De.Cancerologia

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Introdução: O câncer de mama, patologia mais comum entre as mulheres, promove lesão nas estruturas das células ductais e lobulares da mama, assim como no tecido mamário adjacente e sistema linfático. A mastectomia é o procedimento padrão para a retirada do nódulo maligno e áreas acometidas, no qual a cirurgia desenvolve complicações físicas e funcionais. A fototerapia é um dos recursos fisioterapêuticos utilizados para minimizar os problemas ocasionados, oferecendo uma melhora na qualidade de vida das mulheres mastectomizadas. Objetivo: Descrever os possíveis efeitos da fototerapia nas complicações físicas pós-mastectomia. Método: Realizouse uma revisão sistemática nas bases de dados PubMed, LILACS, PEDro, SciELO, Bandolier, EBSCO, Clinical Evidence, MEDLINE e Biblioteca Cochrane no período de 2008 a 2018. Resultados: Dos 87 artigos encontrados, apenas seis preencheram os critérios de inclusão, nota superior de 5/10 na Escala PEDro, sendo detalhados nesta revisão. A fototerapia promoveu diminuição da dor em ombro, diminuição do volume e circunferência do linfedema no membro superior, regulação do sistema linfático e imunológico. Conclusão: Conclui-se que a fototerapia aplicada nas complicações pós-mastectomia mostrou ser uma terapêutica segura em pacientes oncológicos, sugerindo melhora sobre os aspectos da funcionalidade do indivíduo e sua qualidade de vida.

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“…Low intensity phototherapy, more recently termed photobiomodulation (PBM) 1) , has been widely used in medicine since the end of 1960s 2) . For the last 20 years, along with monochromatic or narrow band visible (VIS) and near infrared (IR) light of lasers and light-emitting diodes, polychromatic visible light combined with infrared (pVIS+pIR, 480-3400 nm) has been also actively applied to modulate immune and inflammatory processes, stimulate wound healing and increase blood microcirculation [3][4][5][6][7] . Due to their properties, both monochromatic and polychromatic lights have been used in clinical oncology to reduce the frequency and severity of negative side effects of conservative treatment methods being applied.…”

Section: Introductionmentioning

confidence: 99%

Percutaneous Exposures of volunteers to polychromatic light (480-3400 nm) trigger systemic mechanism of the human myeloma cells growth delay without any effect on bortezomib cytotoxicity in vitro

et al. 2019

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Background and aim: Polychromatic light is actively used in medicine. However, its oncological safety and effect against cytotoxic therapy remains poorly studied. Multiple myeloma (MM) develops in the bone marrow and therefore malignant plasma cells are inaccessible to direct exposure to light. The aim of our work was to study the influence of polychromatic visible and infra-red light (pVIS + pIR) on growth and sensitivity of the myeloma cells to the cytotoxic effect of drug bortezomib (BTZ) through systemic mechanism. Materials and methods: We explored the effect of volunteers blood sera after their 4-daily irradiations with pVIS + pIR light (480-3400 nm) on growth and viability of the human myeloma RPMI 8226 cells in the presence of BTZ at its application in 2 modes: short-term (1 h, 300 nM) and long-term (96 h, 5 nM). Viability and proliferative activity of cells was evaluated by MTT assay. Results: It was found that photomodified blood sera delayed growth of myeloma RPMI 8226 cells (by 25 % in 48 h and 23 % in 96 h) but had no effect on spontaneous and mitogen-induced proliferation of autologous peripheral blood T-and B-lymphocytes. We also revealed that pVIS + pIR did not change RPMI 8226 cells sensitivity to BTZ. Conclusion: The results suggest the systemic mechanism of polychromatic light and argue in favor of its oncological safety during/ after BTZ therapy of MM patients without effect on the drug cytotoxicity.

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Polychromatic light (480–3400nm) similar to the terrestrial solar spectrum without its UV component in post-surgical immunorehabilitation of breast cancer patients

Cited by 7 publications

References 18 publications

Irradiation with Polychromatic Incoherent Low Energy Radiation of Human Peripheral Blood Mononuclear Cells In Vitro: Effects on Cytokine Production

Irradiation with Polychromatic Incoherent Low Energy Radiation of Human Peripheral Blood Mononuclear Cells In Vitro: Effects on Cytokine Production

Fototerapia Pós-Mastectomia: uma Revisão Sistemática

Percutaneous Exposures of volunteers to polychromatic light (480-3400 nm) trigger systemic mechanism of the human myeloma cells growth delay without any effect on bortezomib cytotoxicity in vitro

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