Polyaspartamide‐polylactide electrospun scaffolds for potential topical release of Ibuprofen

Abstract

In this work, the production and characterization of electrospun scaffolds of the copolymer α,β-poly(N-2-hydroxyethyl)-DL-aspartamide-graft-polylactic acid (PHEA-g-PLA), proposed for a potential topical release of Ibuprofen (IBU), are reported. The drug has been chemically linked to PHEA-g-PLA and/or physically mixed to the copolymer before electrospinning. Degradation studies have been performed as a function of time in Dulbecco phosphate buffer solution pH 7.4, for both unloaded and drug-loaded scaffolds. By using an appropriate ratio between drug physically blended to the copolymer and drug-copolymer conjugate, a useful control of its release can be obtained. MTS assay on human dermal fibroblasts cultured onto these scaffolds, showed the absence of toxicity as well as their ability to allow cell adhesion.

Electrospun PLGA Nanofiber Scaffolds Release Ibuprofen Faster and Degrade Slower After In Vivo Implantation

“…However, the evaluation of degradation in that study occurred in PBS, but did not assay degradation in serum. 36 Our findings suggest that both the release properties of IBP and the degradation of the polymer differ in PBS versus serum containing solutions.…”

“…24 The chemical linking of IBP to α,β-poly(N-2-hydroxylethyl)-DL-aspartamide-graft-polylactic acid (PHEA-g-PLA) fibers also alters the release profile compared to the physical incorporation of the drug into fibers. 36 …”

In-situ forming gel-like depot of a polyaspartamide-polylactide copolymer for once a week administration of sulpiride

“…We have demonstrated that PHEA‐g‐PLA copolymer undergoes a degradation faster than PLA alone and it is able to prolong the release of a peptide drug, such as leuprolide. Furthermore, PHEA‐g‐PLA has been also used to prepare scaffolds for tissue engineering [14,15]…”

Heparin functionalized polyaspartamide/polyester scaffold for potential blood vessel regeneration

“…In previous works, we have performed electrospinning of PHEA‐g‐PLA copolymer and prepared fibrillar scaffolds where drug molecules have been linked to hydroxyl groups of PHEA …”