Poly2-methoxyethylacrylate (PMEA) Coated Oxygenator: An ex Vivo Study

Mueller, Xavier M.; Jochheim, David; Augstburger, Monique; Horisberger, Judith; Segesser, Ludwig K. von

doi:10.1177/039139880202500309

Cited by 32 publications

(20 citation statements)

References 16 publications

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“…PEGylated nanoparticles are stable, and further aggregation in the blood stream can be prevented. PMEA also exhibits blood compatibility and low protein adsorption, and has been widely used in commercial biomedical applications [25,26]. The most important feature is that the MEA monomer is highly water soluble, but the PMEA is not [22,27].…”

Section: Peo Improves the Enhanced Permeability And Retention (Epr) Ementioning

confidence: 99%

In situ nano-objects via RAFT aqueous dispersion polymerization of 2-methoxyethyl acrylate using poly(ethylene oxide) macromolecular chain transfer agent as steric stabilizer

Sugihara

Ma'Radzi

Ida

et al. 2015

Polymer

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Poly(ethylene oxide)-poly(2-methoxyethyl acrylate) diblock copolymers (PEO-b-PMEA) are synthesized by RAFT aqueous dispersion polymerization of MEA using poly(ethylene oxide) macromolecular chain transfer agent as a reactive steric stabilizer. Both segments are well-known to be bio-and blood-compatible polymers. This formulation enables the production of various particle morphologies such as spheres, worms, and vesicles from the same block copolymer in water. The synthesis starts when both the reactive steric stabilizer and MEA monomer are dissolved in water; however, the growing polymer is not water-soluble and begins to form nano-objects. In the case of the synthesis of PEO 113-b-MEA 300 diblock copolymers, the nano-objects change from spheres into larger aggregates of worms when the solids concentration in the polymerization increases from 5 to 15 wt% at full monomer conversion. The morphology finally turns into vesicles as the solids concentration increases to 20 wt%. The final block copolymer morphology at full monomer conversion is dictated by not only degree of polymerization of MEA but also the solids concentration in the polymerization mixture.

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Section: Peo Improves the Enhanced Permeability And Retention (Epr) Ementioning

confidence: 99%

In situ nano-objects via RAFT aqueous dispersion polymerization of 2-methoxyethyl acrylate using poly(ethylene oxide) macromolecular chain transfer agent as steric stabilizer

Sugihara

Ma'Radzi

Ida

et al. 2015

Polymer

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“…The poly(2‐methoxyethyl acrylate) (PMEA) has a strong potential to be used in biomedical applications due to its outstanding biocompatibility 1–4. It is already commercialized as a coating for artificial organs,5 being one of the polymers approved by the FDA to be used in human patients. Tanaka reported excellent blood compatibility with respect to coagulation, complement, leukocyte, and platelet systems in vitro and ex vitro of the PMEA when compared with other polymer surfaces 4, 6.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of poly(2‐methoxyethyl acrylate) by single electron transfer—Degenerative transfer living radical polymerization catalyzed by Na₂S₂O₄ in water

Coelho

Góis

Fonseca

et al. 2009

J. Polym. Sci. A Polym. Chem.

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Living radical polymerization of 2-methoxyethyl acrylate (MEA) was achieved by single-electron-transfer/degenerative transfer mediated living radical polymerization (SET-DTLRP) in water catalyzed by sodium dithionate. The poly(2methoxyethyl acrylate) is an amphiphilic polymer with a hydrophobic part (polyethylene chain) and a mildly hydrophilic tail. The plots of number-average molecular weight versus conversion and ln{[M] 0 /[M]} versus time are linear, indicating a controlled polymerization. This method leads to the preparation of a,x-di(iodo) poly(2methoxyethyl acrylate)s (a,x-di(iodo)PMEA) macroinitiators that can be further functionalized. The molecular weight distributions were determined using a combination of three detectors (TriSEC): right-angle light scattering (RALLS), a differential viscometer (DV) and refractive index (RI). The method studied in this work represents a possible route to prepare well-tailored macromolecules made of 2-methoxyethyl acrylate (biocompatible material) in an environmentally friendly reaction medium. To the best of our knowledge there is no previous report dealing with the synthesis of PMEA by any LRP approach in aqueous medium.

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“…We reported that poly(2‐methoxyethylacrylate) (PMEA) shows excellent compatibilities with platelet, white blood cell, coagulation system, and complement system in early stage of reactions in the bio‐defense system 10–12. On the basis of these results, superior blood‐compatible oxygenators coated with PMEA were demonstrated 13–18. To clarify the reason why PMEA has excellent blood compatibility, we have reported unique properties of PMEA 10–12, 19, 20.…”

Section: Introductionmentioning

confidence: 99%

Study on blood compatibility with poly(2‐methoxyethylacrylate)—relationship between surface structure, water structure, and platelet compatibility in 2‐methoxyethylacrylate/2‐hydroxyethylmethacrylate diblock copolymer

Hirota

Ute

Uehara

et al. 2005

J Biomedical Materials Res

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Diblock copolymers composed of 2-methoxyethylacrylate (MEA) and 2-hydroxyethylmethacrylate (HEMA) were firstly prepared (the composition ratio = 90/10, 79/21, 66/34, and 48/52 mol/mol) by anion living polymerization. ESCA analysis of their surface structures (dry state) revealed that PMEA segment was segregated to the top surface in all of the polymers, whereas the results of contact angle of water (wet state) showed that the surfaces were covered with PHEMA segment. In vitro platelet adhesion test showed that these polymers had the excellent compatibility with platelet compared to PHEMA homopolymer. Water structure in the hydrated copolymers was investigated by DSC and freezing bound water was observed for all the polymers like PMEA homopolymer, whereas it was not found in PHEMA homopolymer. Further investigation of water structure based on the results of DSC and EWCMS (equilibrium water content by moisture sorption) suggested that freezing bound water existed in PHEMA segment in addition to PMEA segment. We have proposed that the water plays a key role in the appearance of good blood compatibility of the copolymer, according to our previous works (Tanaka et al. Biomacromolecules 2002;3:36-41, Tanaka et al. J Biomed Mater Res A 2004;68:684-695).

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Poly2-methoxyethylacrylate (PMEA) Coated Oxygenator: An ex Vivo Study

Abstract: When compared with uncoated oxygenator, PMEA coated oxygenator exhibited increased thrombus resistance with lower inlet pressure and lower thrombocyte consumption. In both groups, trauma to red cells was minimal, emphasizing the efficient design of this type of oxygenator.

Cited by 32 publications

References 16 publications

In situ nano-objects via RAFT aqueous dispersion polymerization of 2-methoxyethyl acrylate using poly(ethylene oxide) macromolecular chain transfer agent as steric stabilizer

In situ nano-objects via RAFT aqueous dispersion polymerization of 2-methoxyethyl acrylate using poly(ethylene oxide) macromolecular chain transfer agent as steric stabilizer

Synthesis of poly(2‐methoxyethyl acrylate) by single electron transfer—Degenerative transfer living radical polymerization catalyzed by Na₂S₂O₄ in water

Study on blood compatibility with poly(2‐methoxyethylacrylate)—relationship between surface structure, water structure, and platelet compatibility in 2‐methoxyethylacrylate/2‐hydroxyethylmethacrylate diblock copolymer

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Poly2-methoxyethylacrylate (PMEA) Coated Oxygenator: An ex Vivo Study

Abstract: When compared with uncoated oxygenator, PMEA coated oxygenator exhibited increased thrombus resistance with lower inlet pressure and lower thrombocyte consumption. In both groups, trauma to red cells was minimal, emphasizing the efficient design of this type of oxygenator.

Cited by 32 publications

References 16 publications

In situ nano-objects via RAFT aqueous dispersion polymerization of 2-methoxyethyl acrylate using poly(ethylene oxide) macromolecular chain transfer agent as steric stabilizer

In situ nano-objects via RAFT aqueous dispersion polymerization of 2-methoxyethyl acrylate using poly(ethylene oxide) macromolecular chain transfer agent as steric stabilizer

Synthesis of poly(2‐methoxyethyl acrylate) by single electron transfer—Degenerative transfer living radical polymerization catalyzed by Na2S2O4 in water

Study on blood compatibility with poly(2‐methoxyethylacrylate)—relationship between surface structure, water structure, and platelet compatibility in 2‐methoxyethylacrylate/2‐hydroxyethylmethacrylate diblock copolymer

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Synthesis of poly(2‐methoxyethyl acrylate) by single electron transfer—Degenerative transfer living radical polymerization catalyzed by Na₂S₂O₄ in water