Poly(methyl methacrylate) bone cement composited with mineralized collagen for osteoporotic vertebral compression fractures in extremely old patients

Regenerative Biomaterials

Zhang

Mei

et al. 2021

In this article, we propose a simple scheme of using berberine (BBR) to modify porous calcium phosphate ceramics (named PCPC). These BBR molecules regulate the crystallization of hydroxyapatite nanorods on PCPC. We found that these nanorods and the adsorbed BBR changed the interface micro-environment of PCPC by SEM images. The microenvironment of PCPC surface is essential for promoting BMSCs’ proliferation and differentiation. These results demonstrated that PCPC/BBR markedly improved the bone regeneration of osteoporosis rats. Moreover, PCPC/BBR had significantly increased the expression levels of ALP, osteocalcin and bone morphogenetic protein2 and RUNX2 in BMSCs originated from osteoporosis rats.

Section: Discussionmentioning

confidence: 99%

Repair calvarial defect of osteoporotic rats by berberine functionalized porous calcium phosphate scaffold

Regenerative Biomaterials

Zhang

Mei

et al. 2021

“…Thus, we believe PVP treatment for day surgery procedure is feasible. However, the majority of published studies on PVP treatment still show an average hospital stay above 5 days [4,[9][10][11], and patients need to stay in the hospital, which increases the risk of nosocomial infection but also the hospital costs. Through constant clinical practice, the procedure has further improved, and the feedback from patients has given us the confidence to perform day surgery.…”

Section: Discussionmentioning

confidence: 99%

“…There is sufficient evidence that PVP is an effective mean in relieving pain for symptomatic OVCFs [2,4,7,8]. However, the majority of published studies on PVP for OVCFs still report an average hospital stay of 5 to 15 days, with significant patient inconvenience and cost to the healthcare system [4,[9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Exploration of percutaneous vertebroplasty in the treatment of osteoporotic vertebral compression fracture as day surgery: a retrospective study

Nie

et al. 2021

Eur Spine J

BackgroundThe purpose of this retrospective study was to evaluate and compare the clinical outcomes of patients underwent PVP for OVCF as day surgery with the outcomes of patients managed as traditional inpatients. Methods According to the selection criteria, patients who underwent PVP for single-segment thoracolumbar OVCF were included retrospectively in the day surgery procedure (DSP) group and the traditional inpatient procedure (TIP) group between April 2018 and September 2019. The visual analog scale score (VAS) and Oswestry Disability Index (ODI) score were recorded preoperatively and 1 day, 1 week, 1 month, 3 months, 6 months, and 12 months after surgery. Duration of hospital stay, preoperative waiting time, hospital cost, and postoperative complications were recorded and analyzed. Results A total of 335 patients (53 in DSP group; 282 in TIP group) were enrolled and completed 12-month follow-up. The mean duration of hospital stay, the mean preoperative waiting time, and the mean hospital costs were significant lower in the DSP group. The postoperative VAS and ODI scores in both groups were significantly improved after surgery. Moreover, both VAS and ODI scores at each follow-up stage were also significantly lower than the previous follow-up stage. However, the ODI score in the DSP group was significantly lower at 1-day, 1-week, 1-month, and 3-month follow-up, respectively. For cement leakage and secondary vertebral compression fractures, there was no statistical difference between the two groups. Conclusions We suggest that PVP for OVCFs in day surgery procedure is worthy of wide application.

“…Some typical cases were reported by our own and other researchers and surgeons. 19,20,[22][23][24] In the current study, MC modified bone cements were used to treat patients with Kummell's disease without spinal cord compression, This work was feasible and obtained good clinical results.…”

Section: Introductionmentioning

confidence: 92%

The clinical results of treating Kummell’s disease with mineralized collagen modified polymethyl methacrylate

Kou

et al. 2021

J Biomater Appl

To investigate the clinical results of treating Kummell’s Disease by using mineralized collagen modified polymethyl methacrylate bone cement, 23 cases (23 vertebras) who sustained Kummell’s Disease treated with mineralized collagen modified polymethyl methacrylate bone cement from July 2017 to February 2019 were reviewed retrospectively. The visual analogue scale, vertebral body height, Cobb angle, CT values pre-operation and post-operation as well as incidence of complications were observed. All the patients were successfully followed up with an average period of 11.3 months (ranging from 6 to 12 months). The patients could ambulate on the second day after the operation. The visual analogue scale scores significantly decreased from two days after the operation to the last follow-up compared with that before the operation ( p < 0.05); the average vertebral height and local Cobb angle had significant recovery ( p < 0.05); the CT value of the treated vertebra significantly increased compared with that before the operation ( p < 0.05). Bone cement leakage occurred in one case, anterior edge leakage occurred in one case, and no clinical symptoms caused by bone cement leakage occurred. No re-fracture of the treated vertebral body or adjacent vertebral bodies were observed in the follow-ups. With good osteogenic activity and degradable absorption characteristics, mineralized collagen was compounded with the existing polymethyl methacrylate bone cement to reduce its strength in the vertebral body and enhance biocompatibility, the incidence of adjacent vertebral fractures and re-fractures within the injured vertebrae is significantly reduced, and good clinical results are obtained, which is worthy of popularization.