Poly(<i>N</i>‐isopropylacrylamid)‐Phasendiagramme: 50 Jahre Forschung

Halperin, A.; Kröger, Martin; Winnik, Françoise M.

doi:10.1002/ange.201506663

Cited by 25 publications

(8 citation statements)

References 104 publications

(346 reference statements)

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“…The mechanism of termination reaction for PNIPAM through free radical polymerization has been investigated in the literature [52,53]. The literature kinetics data regarding the PNIPAM termination mechanism take into account three possibilities, with different contributions depending on the reaction conditions.…”

Section: Resultsmentioning

confidence: 99%

Grafting versus Crosslinking of Silk Fibroin-g-PNIPAM via Tyrosine-NIPAM Bridges

et al. 2019

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This paper reports the synthesis and complex characterization of novel polymeric networks based on the crosslinking of Bombyx mori silk fibroin via poly(N-isopropylacrylamide) bridges generated by an ammonium cerium nitrate redox system. The research study gives an understanding of the polymerization mechanism in terms of the generation of radical sites, radical growth and termination reaction, as well as the involvement of modifications on silk fibroin structure and properties. The physico-chemical characterization was carried out by FTIR-ATR, X-ray photoelectron spectroscopy and RAMAN spectroscopy with unravelling the chemical modification. The structural characterization and spatial arrangement by secondary structure were carried out by X-ray diffraction and circular dichroism. The thermal behavior and thermal stability were evaluated by differential scanning calorimetry and thermogravimetric analysis. The novel complex polymer network is intended to be used in the field of smart drug delivery systems.

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Section: Resultsmentioning

confidence: 99%

Grafting versus Crosslinking of Silk Fibroin-g-PNIPAM via Tyrosine-NIPAM Bridges

et al. 2019

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“…Poly( N -isopropylacrylamide) (PNIPAM) is the most commonly used stimuli-sensitive smart polymer, characterized by its well-defined lower critical solution temperature (LCST) of approximately 32 °C in water. Radical polymerization of aqueous N -isopropylacrylamide (NIPAM) solution above the LCST yields soft colloidal particles in the size range of tens of nanometers to a few microns .…”

Section: Introductionmentioning

confidence: 99%

Direct Monitoring of Microgel Formation during Precipitation Polymerization ofN-Isopropylacrylamide Using in Situ SANS

et al. 2019

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Poly( N -isopropylacrylamide) microgels have found various uses in fundamental polymer and colloid science as well as in different applications. They are conveniently prepared by precipitation polymerization. In this reaction, radical polymerization and colloidal stabilization interact with each other to produce well-defined thermosensitive particles of narrow size distribution. However, the underlying mechanism of precipitation polymerization has not been fully understood. In particular, the crucial early stages of microgel formation have been poorly investigated so far. In this contribution, we have used small-angle neutron scattering in conjunction with a stopped-flow device to monitor the particle growth during precipitation polymerization in situ. The average particle volume growth is found to follow pseudo-first order kinetics, indicating that the polymerization rate is determined by the availability of the unreacted monomer, as the initiator concentration does not change considerably during the reaction. This is confirmed by calorimetric investigation of the polymerization process. Peroxide initiator-induced self-crosslinking of N -isopropylacrylamide and the use of the bifunctional crosslinker N , N ′-methylenebisacrylamide are shown to decrease the particle number density in the batch. The results of the in situ small-angle neutron scattering measurements indicate that the particles form at an early stage in the reaction and their number density remains approximately the same thereafter. The overall reaction rate is found to be sensitive to monomer and initiator concentration in accordance with a radical solution polymerization mechanism, supporting the results from our earlier studies.

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“…The LCST of pNIPAM (and VPTT of pNIPAM gels) is known to be sensitive to end groups or, in the case of block copolymers, the other blocks. 86 For example, Xia et al demonstrated that that an N-phenyl amide end group lowered the cloud point of pNIPAM by as much as 9 °C compared to the unsubstituted amide. 87 Additionally, the tacticity of pNIPAM is also known to affect its LCST and the tacticity can be affected by the synthesis conditions, e.g the solvent.…”

Section: Synthesis and Properties Of Paa-b-pnipam Block Copolymersmentioning

confidence: 99%

The effects of cononsolvents on the synthesis of responsive particles via polymerisation-induced thermal self-assembly

Morales-Moctezuma

Spain

2021

Polym. Chem.

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Poly(N‐isopropylacrylamid)‐Phasendiagramme: 50 Jahre Forschung

Cited by 25 publications

References 104 publications

Grafting versus Crosslinking of Silk Fibroin-g-PNIPAM via Tyrosine-NIPAM Bridges

Grafting versus Crosslinking of Silk Fibroin-g-PNIPAM via Tyrosine-NIPAM Bridges

Direct Monitoring of Microgel Formation during Precipitation Polymerization ofN-Isopropylacrylamide Using in Situ SANS

The effects of cononsolvents on the synthesis of responsive particles via polymerisation-induced thermal self-assembly

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