Poly(ethylene oxide)–poly(styrene oxide)–poly(ethylene oxide) copolymers: Micellization, drug solubilization, and gelling features

Cambón, Adriana; Barbosa, Sílvia; Rey‐Rico, Ana; Figueroa-Ochoa, Édgar B.; Soltero, J. F. A.; Yeates, Steven G.; Alvarez‐Lorenzo, Carmen; Concheiro, Ángel; Taboada, Pablo; Mosquera, Vı́ctor

doi:10.1016/j.jcis.2012.06.090

Cited by 17 publications

(15 citation statements)

References 64 publications

(107 reference statements)

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“…Such type of behavior is related to transformation of sol solution into dominantly elastic nature within the frequency range. The viscoelasticity originates from either formation of well-defined micellar structure or micellar growth [63][64][65][66]. In this study, the increase in viscosity has been assigned to the spherical to ellipsoidal micellar transition as also evident from DLS and SANS studies.…”

Section: Rheologymentioning

confidence: 65%

pH induced tuning of size, charge and viscoelastic behavior of aqueous micellar solution of Pluronic ® P104–anthranilic acid mixtures: A scattering, rheology and NMR study

Khimani

Verma

Kumar

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Section: Rheologymentioning

confidence: 65%

pH induced tuning of size, charge and viscoelastic behavior of aqueous micellar solution of Pluronic ® P104–anthranilic acid mixtures: A scattering, rheology and NMR study

Khimani

Verma

Kumar

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…Intermicellar interactions pertain to possible cooperative behavior either between the micelles themselves or to micelles at biological interfaces. It has been shown that the intermicellar interactions play an important role in the determination of the phase behavior, rheology, and dynamics of block copolymer micelles . A time‐resolved SANS study of molecular exchange in 15 wt% polystyrene‐ block ‐poly(ethylene‐ alt ‐propylene) diblock copolymer micelles showed a slower exchange rate than in dilute solutions .…”

Section: Introductionmentioning

confidence: 99%

Effects of Intermicellar Interactions on the Dissociation of Block Copolymer Micelles: SANS and NMR Studies

Cheng

Hammouda

Perahia

2014

Macro Chemistry & Physics

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The effects of intermicellar interactions on the dissociation of block copolymer micelles of polystyrene‐block‐polyisoprene in a selective solvent, decane, are investigated using small‐angle neutron scattering (SANS) and 1H NMR spectroscopy. This well‐studied polymer is used as a model system to correlate intermicellar interactions with overall micellar stability. Decane is a preferential solvent for polyisoprene (PI) and drives the association of the polystyrene (PS) blocks, resulting in spherical micelles with a PS core and a Gaussian PI corona. The dissociation of the PS–PI micelles is triggered by increasing temperature, while the intermicellar interactions are controlled by varying the polymer concentration and modulating temperature. With increasing temperature, the cores of the micelles first swell, followed by a breakdown to smaller micelles, with similar shapes, that eventually dissociate into single molecules. Herein, it is shown for the first time that enhancing the intermicellar interaction delays the dissociation process of the micelles.

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“…In terms of the hydrophobic core composition, biocompatibility, solubility, stability, release rate, and nontoxicity are key prerequisites in selecting the appropriate hydrophobic segment. Commonly used core‐forming hydrophobic polymers for drug delivery can be poly(oxide ether)s, such as poly(propylene oxide) (PPO) in Pluronics and Tetronics copolymers, poly (butylene oxide) (PBO), poly(styrene oxide) (PSO), or poly (phenyl glycidyl ether) (PG); polyesters, such as poly(lactic acid) (PLA), poly(lactide‐ co ‐glycolic acid) (PLGA), and poly(ε‐caprolactone) (PCL); poly( l ‐amino acids), such as poly( l ‐lysine) (PLys); and phospholipids and lipid derivatives, such as disteroyl phosphatidyl ethanolamine …”

Section: Polymeric Micelles: Micellization and Structurementioning

confidence: 99%

“…In this manner, the micelles of the copolymer EO 137 SO 18 EO 137 (the subscripts denote the respective block lengths) have been shown to solubilize five times more of the antifungals griseofulvin, quercetin, and rutin than Pluronic EO 62 PO 39 EO 62 ; mixed micelles led to intermediate solubilization capabilities . EO m SO n EO m triblock copolymers with longer SO blocks have also demonstrated larger effective drug loading than those with shorter SO segments . Nevertheless, a compromise between the chain solubility and micellar core size must be attained by the tuning of the EO and SO block lengths, with an empirical optimal EO–SO ratio found at about 1.5 .…”

Section: Polymeric Micelles As Drug Nanocarriersmentioning

confidence: 99%

Intelligent micellar polymeric nanocarriers for therapeutics and diagnosis

Topete

Barbosa

Taboada

2015

J of Applied Polymer Sci

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Polymeric micelles can be designed and synthesized to bear polymeric blocks with different hydrophilicities; this triggers their self-assembly into micellar aggregates similar to those generated with traditional surfactants. The basic structure consists of a hydrophobic core, capable of containing guest substances, and a hydrophilic shell, which stabilizes the payload and protects it from external degradation or prevents its quick elimination from the body. The accumulation of block copolymer micelles (BCMs) in a target cell or tissue can be accomplished by two main mechanisms, passive and active targeting; this allows the payload release at the site of action when desired. Hence, in this general overview, we pay special attention to newly developed single-stimulus-and multistimuli-responsive delivery systems capable of disassembling and reassembling (in some cases) as a response to changes in their physicochemical properties. Also, special interest is also devoted to multifunctional BCMs incorporating multiple therapeutic agents and/or multiple imaging contrast agents, which can be considered the new generation (third generation) of drug-delivery systems, that is, nanotheranostic platforms. Finally, a summary of BCM-based drug-delivery systems currently under clinical trials is given.

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Poly(ethylene oxide)–poly(styrene oxide)–poly(ethylene oxide) copolymers: Micellization, drug solubilization, and gelling features

Cited by 17 publications

References 64 publications

pH induced tuning of size, charge and viscoelastic behavior of aqueous micellar solution of Pluronic ® P104–anthranilic acid mixtures: A scattering, rheology and NMR study

pH induced tuning of size, charge and viscoelastic behavior of aqueous micellar solution of Pluronic ® P104–anthranilic acid mixtures: A scattering, rheology and NMR study

Effects of Intermicellar Interactions on the Dissociation of Block Copolymer Micelles: SANS and NMR Studies

Intelligent micellar polymeric nanocarriers for therapeutics and diagnosis

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