Poly(butylene succinate-co-ε-caprolactone) Copolyesters: Enzymatic Synthesis in Bulk and Thermal Properties

Núñez, M. R.; Muñoz‐Guerra, Sebastián; Ilarduya, Antxon Martı́nez de

doi:10.3390/polym13162679

Cited by 10 publications

(8 citation statements)

References 37 publications

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“…On the other hand, when the synthesis is carried out in bulk, it restricts enzyme mobility, causing BDO-DA and DLD-DA sequences to be catalyzed at similar rates, resulting in the formation of copolyesters with a random microstructure. Similar results were provided by Ilarduya et al, (42) where enzymatic polycondensation of copolyester materials in bulk led to products with a random microstructure.…”

Section: Resultssupporting

confidence: 86%

Improving the sustainability of enzymatic synthesis of poly(butylene adipate)-based copolyesters. Polycondensation reaction in bulk vs in diphenyl ether

Sokołowska,

Molnar,

Puskas

et al. 2024

Preprint

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In response to mounting global concerns such as CO2 emissions, environmental pollution, and the depletion of fossil resources, the field of polymer science is shifting its focus toward sustainability. This research investigates the synthesis of poly(butylene adipate)-co-(dilinoleic adipate) (PBA-DLA) copolymers using two distinct methods: bulk polycondensation and polycondensation in diphenyl ether. The objective is to assess the environmental impact, chemical structure, composition, and key properties of the resulting copolymers, with a particular emphasis on determining the viability of bulk synthesis as a more sustainable approach. Various analytical methods, including nuclear magnetic resonance spectroscopy (NMR), Fourier transform infrared spectroscopy (FTIR), and size exclusion chromatography (SEC), were employed to confirm successful copolymerization and highlight differences in molecular weight and microstructure. Additionally, thermal and dynamic mechanical analyses were conducted to thoroughly characterize the copolymers' properties. This research provides significant findings into the sustainable production of PBA-DLA copolymers, offering a more environmentally friendly approach without compromising product quality or performance.

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Section: Resultssupporting

confidence: 86%

Improving the sustainability of enzymatic synthesis of poly(butylene adipate)-based copolyesters. Polycondensation reaction in bulk vs in diphenyl ether

Sokołowska,

Molnar,

Puskas

et al. 2024

Preprint

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“…Three of them ([ 97,98,99 ]) did not present the enzymatic synthesis, but the degradation of the polymer. One of them, [ 100 ] described the synthesis process for homopolymers (not fitting the categorization), and Núñez, Muñoz‐Guerra, and Martínez De Ilarduya [ 101 ] described the synthesis of Poly(Butylene succinate‐ co ‐ ε ‐caprolactone), through dimethyl succinate, 1,4‐butanediol, and ε ‐caprolactone, obtaining stable materials up to 300 °C.…”

Section: Succinic Copolymersmentioning

confidence: 99%

Current Status and Perspectives on the Green Synthesis of Succinic Polyesters for Value‐Added Applications

Gucker

Sayer

Oliveira

et al. 2023

Macro Reaction Engineering

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Polybutylene succinate (PBS) and other succinic (co)polyesters are biodegradable polymers with favorable mechanical and thermal properties that find use in many applications. Due to environmental concerns, polymers based on succinic acid (SA) have been gaining attention, as SA can be produced through biotechnological processes. Thus, this review aims to highlight the synthesis and characteristics of PBS and other succinic copolyesters, with emphasis in the works employing metallic catalysts and enzymes. In addition, the modification of the macromolecular structure by copolymerization or postpolymerization is also discussed. Currently, metallic catalysts are normally used in the synthesis of these materials, under conditions of high temperatures, which can favor the occurrence of thermal degradation, increasing the dispersion of chain length distributions. Moreover, the incrustation of metallic catalysts in polymeric materials makes their application in biomedical products difficult, due to toxicity requirements. In this context, enzymatic catalysis is gaining ground, offering milder synthesis temperatures, high selectivity, and uniformity of synthesized products. This biotechnological route can substitute oligomerization processes with metallic catalysis in future industrial processes, producing materials free from metallic contamination. In addition to production by catalytic routes, trends for future applications of succinic (co)polyesters are presented, with emphasis on the value‐added materials sectors.

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“…This study shows that bulk polymerization catalyzed by CALB is a simple and effective method for the synthesis of PBSCL copolymers. In addition, the copolymer can be safely applied to biomedicine due to the avoidance of using catalysts containing metal components …”

Section: Application Of Calb In Different Fields Of the Pharmaceutica...mentioning

confidence: 99%

“…In addition, the copolymer can be safely applied to biomedicine due to the avoidance of using catalysts containing metal components. 71 However, small molecular weight polymers seem to be more favorable for drug delivery applications because the larger the molecular weight of the polymer, the longer the degradation time. Therefore, Kantor and his team improved the synthesis of polyester.…”

Section: Catalytic Synthesis Of Drug Carriersmentioning

confidence: 99%

See 1 more Smart Citation

Application of Lipase B from Candida antarctica in the Pharmaceutical Industry

Wang,

Zhang,

et al. 2023

Ind. Eng. Chem. Res.

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The use of biocatalysts in pharmaceutical production is an important approach for the pharmaceutical industry to achieve green manufacturing. Compared to other lipases, Candida antarctica lipase B (CALB) possesses numerous excellent characteristics due to its unique structure. It exhibits relatively strong catalytic activity toward both water-insoluble and water-soluble substances. It shows high selectivity in hydrolysis and organic synthesis reactions. These properties are crucial for drug synthesis. However, current research shows that the use of CALB as a catalyst still faces challenges such as high cost, poor stability, and difficulty in large-scale production. Therefore, this paper mainly explores the advantages of CALB in the pharmaceutical industry and the challenges that still need to be overcome. It introduces the application progress of CALB in the pharmaceutical industry and finally provides a prospect for future research directions, hoping to provide appropriate references for related research.

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Poly(butylene succinate-co-ε-caprolactone) Copolyesters: Enzymatic Synthesis in Bulk and Thermal Properties

Cited by 10 publications

References 37 publications

Improving the sustainability of enzymatic synthesis of poly(butylene adipate)-based copolyesters. Polycondensation reaction in bulk vs in diphenyl ether

Improving the sustainability of enzymatic synthesis of poly(butylene adipate)-based copolyesters. Polycondensation reaction in bulk vs in diphenyl ether

Current Status and Perspectives on the Green Synthesis of Succinic Polyesters for Value‐Added Applications

Application of Lipase B from Candida antarctica in the Pharmaceutical Industry

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