Poly(amidoamine) dendrimers: covalent and supramolecular synthesis

Lyu, Zhenbin; Ding, Ling; Huang, Adela Ya Ting; Kao, Ching Huei; Peng, Ling

doi:10.1016/j.mtchem.2019.04.004

Cited by 106 publications

(75 citation statements)

References 70 publications

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“…Furthermore, the use of dendrimers building blocks allows to increase both the pharmaco-kinetics and pharmaco-dynamic properties of the assembled nanocarriers, thus stimulating many therapeutic investigations including diabetic, Parkinson's disease, glaucoma, anticancer and antimicrobial agents [128,129]. Finally, coordination chemistry has been used to prepare a great variety of dendrimers-based supramolecular nanomaterials and dendritic hybrids nanoplatforms [130,131]. With appropriate choices of dendrimers containing both metal centers (or nanocrystals) and complementary functional moieties, it is possible to control dimension, morphology, functional properties and stability of most accessible and programmable building blocks, such as the minidendrimers, minidendrons and dendronized polymers [130,131].…”

Section: Hyperbranched/dendritic Polymers: Self-assembly and Co-assemmentioning

confidence: 99%

“…Finally, coordination chemistry has been used to prepare a great variety of dendrimers-based supramolecular nanomaterials and dendritic hybrids nanoplatforms [130,131]. With appropriate choices of dendrimers containing both metal centers (or nanocrystals) and complementary functional moieties, it is possible to control dimension, morphology, functional properties and stability of most accessible and programmable building blocks, such as the minidendrimers, minidendrons and dendronized polymers [130,131]. The development of the so called "lock and key" assembling processes stimulated different investigations in areas of supramolecular dendrimers assemblies including signaling, diagnostics and energy harvesting and conversion [130,131].…”

Section: Hyperbranched/dendritic Polymers: Self-assembly and Co-assemmentioning

confidence: 99%

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Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications

et al. 2020

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In this paper, we survey recent advances in the self-assembly processes of novel functional platforms for nanomaterials and biomaterials applications. We provide an organized overview, by analyzing the main factors that influence the formation of organic nanostructured systems, while putting into evidence the main challenges, limitations and emerging approaches in the various fields of nanotechology and biotechnology. We outline how the building blocks properties, the mutual and cooperative interactions, as well as the initial spatial configuration (and environment conditions) play a fundamental role in the construction of efficient nanostructured materials with desired functional properties. The insertion of functional endgroups (such as polymers, peptides or DNA) within the nanostructured units has enormously increased the complexity of morphologies and functions that can be designed in the fabrication of bio-inspired materials capable of mimicking biological activity. However, unwanted or uncontrollable effects originating from unexpected thermodynamic perturbations or complex cooperative interactions interfere at the molecular level with the designed assembly process. Correction and harmonization of unwanted processes is one of the major challenges of the next decades and requires a deeper knowledge and understanding of the key factors that drive the formation of nanomaterials. Self-assembly of nanomaterials still remains a central topic of current research located at the interface between material science and engineering, biotechnology and nanomedicine, and it will continue to stimulate the renewed interest of biologist, physicists and materials engineers by combining the principles of molecular self-assembly with the concept of supramolecular chemistry.

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Section: Hyperbranched/dendritic Polymers: Self-assembly and Co-assemmentioning

confidence: 99%

Section: Hyperbranched/dendritic Polymers: Self-assembly and Co-assemmentioning

confidence: 99%

Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications

et al. 2020

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“…As noted in Table 1, Tomalia and Newkome-type dendrimers containing symmetrical, equal-branch cell segmented interior topologies have dominated a majority of the activity in the dendrimer field since inception, based on total literature/patent citations. An overview of PAMAM dendrimer covalent and supramolecular syntheses has been recently reported by Peng et al [43].…”

Section: Historical Overview: First Divergently Synthesized Dendrimermentioning

confidence: 99%

The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

Tomalia

Nixon²,

Hedstrand³

2020

Biomolecules

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This article reviews progress over the past three decades related to the role of dendrimer-based, branch cell symmetry in the development of advanced drug delivery systems, aqueous based compatibilizers/solubilizers/excipients and nano-metal cluster catalysts. Historically, it begins with early unreported work by the Tomalia Group (i.e., The Dow Chemical Co.) revealing that all known dendrimer family types may be divided into two major symmetry categories; namely: Category I: symmetrical branch cell dendrimers (e.g., Tomalia, Vögtle, Newkome-type dendrimers) possessing interior hollowness/porosity and Category II: asymmetrical branch cell dendrimers (e.g., Denkewalter-type) possessing no interior void space. These two branch cell symmetry features were shown to be pivotal in directing internal packing modes; thereby, differentiating key dendrimer properties such as densities, refractive indices and interior porosities. Furthermore, this discovery provided an explanation for unimolecular micelle encapsulation (UME) behavior observed exclusively for Category I, but not for Category II. This account surveys early experiments confirming the inextricable influence of dendrimer branch cell symmetry on interior packing properties, first examples of Category (I) based UME behavior, nuclear magnetic resonance (NMR) protocols for systematic encapsulation characterization, application of these principles to the solubilization of active approved drugs, engineering dendrimer critical nanoscale design parameters (CNDPs) for optimized properties and concluding with high optimism for the anticipated role of dendrimer-based solubilization principles in emerging new life science, drug delivery and nanomedical applications.

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“…In fact, this can be observed well in hydrogels composed from hyperbranched polymers and dendrimers. Whilst hyperbranched polymers are highly disperse and the branching is random, dendrimers are highly defined structures that are almost monodisperse macromers after purification [ 81 ]. Different batches of macroscopic hydrogels can vary greatly when composed of hyperbranched polymers, whilst a hydrogel derived from a dendrimer of the same chemical composition will show reproducible and fixed characteristics [ 82 ].…”

Section: General Factors Influencing the Design Of Hydrogels For Rmentioning

confidence: 99%

Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

et al. 2020

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Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompatibility, responsivity and displaying tunable chemical and mechanical properties. A complex scenario of molecular factors and conditions have to be taken into account to ensure the correct functionality of the bio-hydrogel as a scaffold or a delivery system, including the polymer backbone and biomolecule choice, polymerization conditions, architecture and biocompatibility. In this review, we present these key factors and conditions that have to match together to ensure the correct functionality of the bio-conjugated hydrogel. We then present recent examples of bio-conjugated hydrogel systems paving the way for regenerative medicine applications.

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Poly(amidoamine) dendrimers: covalent and supramolecular synthesis

Cited by 106 publications

References 70 publications

Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications

Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications

The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties

Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

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