Biochemical Pharmacology volume 80, issue 9, P1326-1334 2010 DOI: 10.1016/j.bcp.2010.07.025 View full text
Shilpa Tyagi, Kulpreet Bhui, Richa Singh, Madhulika Singh, Sheikh Raisuddin, Yogeshwer Shukla

Abstract: Polo-like kinase 1 (Plk1), a critical regulator of mitotic entry, progression and exit, has been shown to be involved in a variety of cancers and thus is becoming an attractive target for cancer management. In case of DNA damage, Plk1 not only inhibits p53 independent apoptosis by dysfunctioning p73α but also allows cells to recover from growth arrest. Here, we showed the effects of knocking down plk1 gene through small interference RNA (siRNA) on cell cycle progression, proliferation and chemosensitivity of p…

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