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“…These results differ from other studies that analyzed the same polymorphic region SNP -1438A/G [26,27]. Tander et al [26] evaluated 80 patients with fibromyalgia and 91 controls did not obtain statistically significant results among those with the SNPs of the gene 5-HTR2A (−1438A/G and 102 T/C) and COMT and fibromyalgia (p > 0.05).…”
Section: Discussioncontrasting
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“…These results differ from other studies that analyzed the same polymorphic region SNP -1438A/G [26,27]. Tander et al [26] evaluated 80 patients with fibromyalgia and 91 controls did not obtain statistically significant results among those with the SNPs of the gene 5-HTR2A (−1438A/G and 102 T/C) and COMT and fibromyalgia (p > 0.05).…”
Section: Discussioncontrasting
“…Tander et al [26] evaluated 80 patients with fibromyalgia and 91 controls did not obtain statistically significant results among those with the SNPs of the gene 5-HTR2A (−1438A/G and 102 T/C) and COMT and fibromyalgia (p > 0.05). Whereas in the survey conducted by Matsuda et al [27] there was an association between fibromyalgia with the COMT gene, but the SNPs of the gene 5-HTR2A (−1438A/G and 102 T/C) showed no such association.…”
Section: Discussionmentioning
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“…Pesquisas moleculares deram início a diversas discussões a respeito dos mecanismos que correspondem, ou deveriam corresponder, aos processos mentais. Em geral, as pesquisas que tratam do funcionamento molecular no cérebro buscam, em grande parte, elucidações que contribuirão para o tratamento de determinadas patologias neurológicas como o Alzheimer, Parkinson e a fi bromialgia (MATSUDA et al, 2010).…”
Section: Introductionunclassified
“…Fibromyalgia (FM) is a non-inflammatory musculoskeletal chronic syndrome, whose etiology is unknown, characterized by a diffuse pain, increase in palpation sensitivity and such symptoms as tiredness, insomnia, anxiety, depression, cold intolerance and otologic complaints. Although the FM-controlling physiological mechanisms have not been determined, neuroendocrine, genetic or molecular factors can be involved (1,2).…”
Section: Introductionmentioning