2009
DOI: 10.1590/s0104-42302009000600023 View full text |Buy / Rent full text
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Abstract: Polymyxins are polypeptide antibiotics with strong action against Gram-negative bacteria. Their use was almost halted between 1970 and 1980 with the advent of less toxic compounds. The emergence of multiresistant Gram-negative bacterial strains, mainly in intensive care unit patients, and the absence of new antimicrobials that were effective against these pathogens, there has been renewed interest in polymyxins in recent years. The major adverse effect of this class of antibiotics is nephrotoxicity. Currently,… Show more

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“…1). Polimixina B não é um antimicrobiano utilizado na rotina de tratamento da mastite, e seu uso é recomendado em casos de mastites ambientais ocasionadas por bactérias gram-negativas, devido à sua capacidade de inativar endotoxinas (LPS) (Mendes;Burdmann, 2009). A avaliação da suscetibilidade à polimixina B é uma prova utilizada para a diferenciação entre S. aureus (resistente) e Staphylococcus intermedius (sensível) (Quinn et al, 1994).…”
Section: Resultsunclassified
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“…1). Polimixina B não é um antimicrobiano utilizado na rotina de tratamento da mastite, e seu uso é recomendado em casos de mastites ambientais ocasionadas por bactérias gram-negativas, devido à sua capacidade de inativar endotoxinas (LPS) (Mendes;Burdmann, 2009). A avaliação da suscetibilidade à polimixina B é uma prova utilizada para a diferenciação entre S. aureus (resistente) e Staphylococcus intermedius (sensível) (Quinn et al, 1994).…”
Section: Resultsunclassified
“…The adjustment in the dose of the drug is needed to ensure that the correct therapeutic range is reached and the incorrect dosage or maintenance of high doses increases the incidence of AKI (16,23) .…”
mentioning
“…Elas constituem um grupo de cinco compostos químicos intimamente relacionados, as Polimixinas A, B, C, D e E (MENDES; BURDMANN, 2009). Dentro desse grupo, duas substâncias apresentam aplicação terapêutica.…”
Section: Históricounclassified
“…As polimixinas são antimicrobianos polipeptídicos que atuam inativando a porção lipídica A da endotoxina presente na membrana externa da bactéria ocasionando a morte bacteriana (MENDES; BURDMANN, 2009). Essa classe de medicamentos possue cinco tipos de fármacos, porém, apenas a Polimixina B e a Polimixina E (colistina) são utilizadas clinicamente (FALAGAS et al, 2010).…”
Section: Introductionunclassified